Catalog No.
PHB89201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human OAS1 (Ser74-Pro165).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
E18/E16,(2-5')oligo(A) synthase 1,2-5A synthase 1,2'-5'-oligoadenylate synthase 1,OAS1,OIAS,p46/p42 OAS
Purification
Purified by antigen affinity column.
Accession
P00973
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response., PMID:38597182
Type I interferon pathway activation across the antiphospholipid syndrome spectrum: associations with disease subsets and systemic antiphospholipid syndrome presentation., PMID:38550580
TRIM5 Promotes Systemic Lupus Erythematosus Through CD4(+) T Cells and Macrophage., PMID:37614552
Multi-phasic gene profiling using candidate gene approach predict the capacity of specific antibody production and maintenance following COVID-19 vaccination in Japanese population., PMID:37564647
A specific anti-COVID-19 BNT162b2 vaccine-induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients., PMID:36969367
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types., PMID:35659055
Association between interferon-I producing plasmacytoid dendritic cells and thrombotic antiphospholipid syndrome., PMID:35612283
Japanese Encephalitis Virus Persistence in Porcine Tonsils Is Associated With a Weak Induction of the Innate Immune Response, an Absence of IFNγ mRNA Expression, and a Decreased Frequency of CD4+CD8+ Double-Positive T Cells., PMID:35281443
Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module., PMID:35181735
Comparative Analysis on Abnormal Methylome of Differentially Expressed Genes and Disease Pathways in the Immune Cells of RA and SLE., PMID:34079550
Proteomic Analysis of ISGylation in Immortalized Porcine Alveolar Macrophage Cell Lines Induced by Type I Interferon., PMID:33671165
Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A., PMID:33445752
Prediabetes Induced by a Single Autoimmune B Cell Clone., PMID:32625203
Signature of genome wide gene expression in classical swine fever virus infected macrophages and PBMCs of indigenous vis-a-vis crossbred pigs., PMID:31935504
Regulation of expansion of CD11c+ B cells and anti-viral immunity by epithelial V-like antigen., PMID:31818507
Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta., PMID:31175514
Genetic susceptibility to West Nile virus infection in Camargue horses., PMID:31005660
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug., PMID:30814222
TLR3 Activation of Hepatic Stellate Cell Line Suppresses HBV Replication in HepG2 Cells., PMID:30619284
Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer., PMID:30134903
Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells., PMID:29777205
Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus., PMID:29702095
A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection., PMID:29242559
Expression and molecular cloning of interferon stimulated genes in buffalo (Bubalus bubalis)., PMID:28708533
Efficacy of novel antibody-based drugs against rhinovirus infection: In vitro and in vivo results., PMID:28356234
Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients., PMID:28046052
Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages., PMID:27734899
2',5'-Oligoadenylate synthetase 1(OAS1) inhibits PRRSV replication in Marc-145 cells., PMID:27395032
Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus., PMID:26568589
Induction of interferon-λ contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells., PMID:26502803
HCV dsRNA-Activated Macrophages Inhibit HCV Replication in Hepatocytes., PMID:26322111
Dengue Virus Infection of Primary Endothelial Cells Induces Innate Immune Responses, Changes in Endothelial Cells Function and Is Restricted by Interferon-Stimulated Responses., PMID:25902155
Anti-interferon-α neutralizing antibody induced telaprevir resistance under the interferon-α plus telaprevir treatment in vitro., PMID:25450683
Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus., PMID:25344775
Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells., PMID:24333668
Induction of interferon-λ contributes to Toll-like receptor-3-activated hepatic stellate cell-mediated hepatitis C virus inhibition in hepatocytes., PMID:23647955
Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii., PMID:23558133
Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages., PMID:23401273
IL-17A but not IL-22 suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line., PMID:23274784
Retinoic acid inducible gene-I (RIG-I) signaling of hepatic stellate cells inhibits hepatitis C virus replication in hepatocytes., PMID:23060457
Her2/neu small interfering RNA delivered in culture by a streptavidin nanoparticle., PMID:22520071
Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs., PMID:22426325
Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine., PMID:21939710
Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment., PMID:20096109
2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine., PMID:20079393
[Relationship between SNP rs10774671 on OAS-1 gene and spontaneous HBeAg seroconversion in chronic HBV infection]., PMID:19799013
Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus., PMID:18772188
Up-regulation of chemokine gene transcripts and T-cell infiltration into the central nervous system and dorsal root ganglia are characteristics of experimental European bat lyssavirus type 2 infection of mice., PMID:18569456
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus., PMID:16947629
Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment., PMID:16077073
For research use only. Not for human or drug use.
