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InVivoMAb Anti-HPV16 L2/Minor capsid protein L2 (Iv0015)

Catalog #:   VVV20802 Specific References (111) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, Neutralization, WB
Accession: P03107
Overview

Catalog No.

VVV20802

Species reactivity

Human papillomavirus type 16

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Minor capsid protein L2, L2

Concentration

1.51 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03107

Applications

ELISA, Neutralization, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0015

Data Image
  • SDS-PAGE
    SDS PAGE for HPV16 L2/Minor capsid protein L2 Antibody
References

L2, the minor capsid protein of papillomavirus. PMID: 23689062

Human Papillomavirus Minor Capsid Protein L2 Mediates Intracellular Trafficking into and Passage beyond the Endoplasmic Reticulum. PMID: 35608352

Genetic variability in minor capsid protein (L2 gene) of human papillomavirus type 16 among Indian women. PMID: 35552511

Insights into the role and function of L2, the minor capsid protein of papillomaviruses. PMID: 19169853

Minor Capsid Protein L2 Polytope Induces Broad Protection against Oncogenic and Mucosal Human Papillomaviruses. PMID: 29212932

Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2. PMID: 29207511

Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection. PMID: 35458534

Topography of the Human Papillomavirus Minor Capsid Protein L2 during Vesicular Trafficking of Infectious Entry. PMID: 26246568

Modification of human papillomavirus minor capsid protein L2 by sumoylation. PMID: 20739540

Antibody Competition Reveals Surface Location of HPV L2 Minor Capsid Protein Residues 17-36. PMID: 29125554

Human papillomavirus 16 minor capsid protein L2 helps capsomeres assemble independently of intercapsomeric disulfide bonding. PMID: 16175337

Refolding and in vitro characterization of human papillomavirus 16 minor capsid protein L2. PMID: 30375341

Efficient Inhibition of Human Papillomavirus Infection by L2 Minor Capsid-Derived Lipopeptide. PMID: 31387913

High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility. PMID: 33568731

Human papillomavirus type 16 minor capsid protein l2 N-terminal region containing a common neutralization epitope binds to the cell surface and enters the cytoplasm. PMID: 11160736

The minor capsid protein L2 contributes to two steps in the human papillomavirus type 31 life cycle. PMID: 15767396

Production and characterization of virus-like particles of grapevine fanleaf virus presenting L2 epitope of human papillomavirus minor capsid protein. PMID: 31752839

The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors. PMID: 15507604

Nuclear translocation of papillomavirus minor capsid protein L2 requires Hsc70. PMID: 15140951

Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines. PMID: 31819523

Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles. PMID: 14722267

The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to PML oncogenic domains. PMID: 9420209

Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. PMID: 25693203

Conformational and linear epitopes on virus-like particles of human papillomavirus type 33 identified by monoclonal antibodies to the minor capsid protein L2. PMID: 7595373

Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16. PMID: 12857908

Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2. PMID: 26003490

The high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic. PMID: 22154072

A surface immunodeterminant of human papillomavirus type 16 minor capsid protein L2. PMID: 9636375

Nuclear location of minor capsid protein L2 is required for expression of a reporter plasmid packaged in HPV51 pseudovirions. PMID: 19766281

Identification of a dynein interacting domain in the papillomavirus minor capsid protein l2. PMID: 16775357

Prophylactic papillomavirus vaccines. PMID: 24559559

Master mitotic kinases regulate viral genome delivery during papillomavirus cell entry. PMID: 36683055

Natural variants in the major neutralizing epitope of human papillomavirus minor capsid protein L2. PMID: 22961598

Virus-like Particle-Based L2 Vaccines against HPVs: Where Are We Today? PMID: 31877975

Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2. PMID: 19095951

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection. PMID: 26569287

Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach. PMID: 26362430

Nuclear import strategies of high-risk HPV18 L2 minor capsid protein. PMID: 16733063

A pan-HPV vaccine based on bacteriophage PP7 VLPs displaying broadly cross-neutralizing epitopes from the HPV minor capsid protein, L2. PMID: 21858066

Arrangement of L2 within the papillomavirus capsid. PMID: 18367526

Host cell transcriptome modification upon exogenous HPV16 L2 protein expression. PMID: 29207600

The positively charged termini of L2 minor capsid protein required for bovine papillomavirus infection function separately in nuclear import and DNA binding. PMID: 15564455

Human Papillomavirus Major Capsid Protein L1 Remains Associated with the Incoming Viral Genome throughout the Entry Process. PMID: 28566382

A membrane-destabilizing peptide in capsid protein L2 is required for egress of papillomavirus genomes from endosomes. PMID: 16378978

The l2 minor capsid protein of low-risk human papillomavirus type 11 interacts with host nuclear import receptors and viral DNA. PMID: 16873281

Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16. PMID: 36815785

Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. PMID: 16432208

The Cytoskeletal Adaptor Obscurin-Like 1 Interacts with the Human Papillomavirus 16 (HPV16) Capsid Protein L2 and Is Required for HPV16 Endocytosis. PMID: 27654294

Protective immunity to rabbit oral and cutaneous papillomaviruses by immunization with short peptides of L2, the minor capsid protein. PMID: 12208958

Common neutralization epitope in minor capsid protein L2 of human papillomavirus types 16 and 6. PMID: 10364381

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PMID: 28464022

Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein. PMID: 16257028

Developing vaccines against minor capsid antigen L2 to prevent papillomavirus infection. PMID: 19421199

Interaction of the papillomavirus transcription/replication factor, E2, and the viral capsid protein, L2. PMID: 11040122

Progress and prospects for L2-based human papillomavirus vaccines. PMID: 26901354

Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2. PMID: 12033769

Monoclonal antibodies recognizing cross-neutralization epitopes in human papillomavirus 16 minor capsid protein L2. PMID: 23051711

Cyclophilins facilitate dissociation of the human papillomavirus type 16 capsid protein L1 from the L2/DNA complex following virus entry. PMID: 22761365

Optimized production strategy of the major capsid protein HPV 16L1 non-assembly variant in E. coli. PMID: 32681956

Assembly of the major and the minor capsid protein of human papillomavirus type 33 into virus-like particles and tubular structures in insect cells. PMID: 8178438

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates. PMID: 33802456

Cell-Free Expression of HPV16 Minor Capsid Protein L2 and Its Interaction with S100A10., PMID:40415288

TAGLN2-mediated Actin Cytoskeleton Stabilization Promotes Proliferation and Metastasis of Ovarian Carcinoma., PMID:40247723

HPV16 entry requires dynein for minus-end transport and utilizes kinesin Kif11 for plus-end transport along microtubules during mitosis., PMID:39629998

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility., PMID:39572555

Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans-Golgi network during virus entry., PMID:39431827

Immunoinformatics approach for design novel multi-epitope prophylactic and therapeutic vaccine based on capsid proteins L1 and L2 and oncoproteins E6 and E7 of human papillomavirus 16 and human papillomavirus 18 against cervical cancer., PMID:39039819

A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning., PMID:38909779

The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection., PMID:38829892

A Peptide Derived from Sorting Nexin 1 Inhibits HPV16 Entry, Retrograde Trafficking, and L2 Membrane Spanning., PMID:38826391

Advances on two serological assays for human papillomavirus provide insights on the reactivity of antibodies against a cross-neutralization epitope of the minor capsid protein L2., PMID:38022617

Sequence-independent activity of a predicted long disordered segment of the human papillomavirus type 16 L2 capsid protein during virus entry., PMID:37819982

Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope., PMID:37798448

Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide., PMID:37684534

Sequence independent activity of a predicted long disordered segment of the human papillomavirus L2 capsid protein during virus entry., PMID:36993745

Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16., PMID:36815785

Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas., PMID:36680181

Next generation L2-based HPV vaccines cross-protect against cutaneous papillomavirus infection and tumor development., PMID:36263027

Detection of HPV16 viral load in L2 gene as a related predictor of cervical cancer among women in Dhi-Qar province by qRT-PCR., PMID:36214947

HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection., PMID:35891458

Human Papillomavirus Type 16 L2 Gene Sequence Variation Analysis in Indonesian Cervical Cancer Specimens., PMID:35763643

RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer., PMID:35703545

Human Papillomavirus Minor Capsid Protein L2 Mediates Intracellular Trafficking into and Passage beyond the Endoplasmic Reticulum., PMID:35608352

Genetic variability in minor capsid protein (L2 gene) of human papillomavirus type 16 among Indian women., PMID:35552511

Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection., PMID:35458534

Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine., PMID:35139303

HPV16 Entry into Epithelial Cells: Running a Gauntlet., PMID:34960729

Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing., PMID:34860285

A respirable HPV-L2 dry-powder vaccine with GLA as amphiphilic lubricant and immune-adjuvant., PMID:34740725

Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids., PMID:34696452

Designing a therapeutic and prophylactic candidate vaccine against human papillomavirus through vaccinomics approaches., PMID:34547435

Immunological responses and anti-tumor effects of HPV16/18 L1-L2-E7 multiepitope fusion construct along with curcumin and nanocurcumin in C57BL/6 mouse model., PMID:34516991

In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses., PMID:34308516

Mutation Profiles, Glycosylation Site Distribution and Codon Usage Bias of Human Papillomavirus Type 16., PMID:34209097

Computational Modeling of Immune Response Triggering Immunogenic Peptide Vaccine Against the Human Papillomaviruses to Induce Immunity Against Cervical Cancer., PMID:33973819

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates., PMID:33802456

Human Papillomavirus infection requires the CCT Chaperonin Complex., PMID:33731457

Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP., PMID:33573433

High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility., PMID:33568731

A Scalable Manufacturing Approach to Single Dose Vaccination against HPV., PMID:33478147

Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists., PMID:33309485

Human Papillomavirus 16 L2 Recruits both Retromer and Retriever Complexes during Retrograde Trafficking of the Viral Genome to the Cell Nucleus., PMID:33177206

Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes., PMID:32967963

Optimized production strategy of the major capsid protein HPV 16L1 non-assembly variant in E. coli., PMID:32681956

Correlation between cervical HPV DNA detection and HPV16 seroreactivity measured with L1-only and L1+L2 viral capsid antigens., PMID:32510304

The possible regions to design Human Papilloma Viruses vaccine in Iranian L1 protein., PMID:32435064

Cell-penetrating peptide inhibits retromer-mediated human papillomavirus trafficking during virus entry., PMID:32123072

Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines., PMID:31819523

Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome., PMID:31743367

Production and Preliminary In Vivo Evaluations of a Novel in silico-designed L2-based Potential HPV Vaccine., PMID:31729940

In silico/In vivo analysis of high-risk papillomavirus L1 and L2 conserved sequences for development of cross-subtype prophylactic vaccine., PMID:31645650

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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InVivoMAb Anti-HPV16 L2/Minor capsid protein L2 (Iv0015) [VVV20802]
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