Anti-C1R Polyclonal Antibody

Catalog No.

PHB87501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C1R (Ala356-Asp705).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

C1R,Complement component 1 subcomponent r,Complement C1r subcomponent

Purification

Purified by antigen affinity column.

Accession

P00736

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS., PMID:39774799

Generation of rabbit single-chain variable fragments with different physicochemical and biological properties by complementary determining region-grafting technology., PMID:39198103

Expression and function of the major histocompatibility complex (MHC) class I chain-related A (MICA)*010 in NK cell killing activity., PMID:39116667

Familial aggregation of diffuse cutaneous systemic sclerosis: Interplay of C1r gene defect, susceptible HLA haplotype and autoantibodies., PMID:38923752

C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells., PMID:38866870

The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi., PMID:38552741

Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report., PMID:38469558

Complex changes in serum protein levels in COVID-19 convalescents., PMID:38396092

Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway-mediated disorders., PMID:38022610

The axis of complement C1 and nucleolus in antinuclear autoimmunity., PMID:37359557

HLA-B*27 Heavy Chain Homo-Oligomers Promote the Cytotoxicity of NK Cells via Activation of PI3K/AKT Signaling., PMID:36295572

Complement C1s as a diagnostic marker and therapeutic target: Progress and propective., PMID:36275687

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis., PMID:36012546

Mycobacterium tuberculosis Affects Protein and Lipid Content of Circulating Exosomes in Infected Patients Depending on Tuberculosis Disease State., PMID:35453532

Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing., PMID:35312359

Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion., PMID:35216207

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases., PMID:34155115

Bovine neonate is deficient in innate immunity at birth., PMID:33640760

Functional recombinant human complement C1q with different affinity tags., PMID:33621564

Complement evasion strategies of Borrelia burgdorferi sensu lato., PMID:32748966

Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function., PMID:32196558

Salivary Scavenger and Agglutinin (SALSA) Is Expressed in Mucosal Epithelial Cells and Decreased in Bronchial Epithelium of Asthmatic Horses., PMID:31850379

CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo., PMID:31807014

Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway., PMID:31739194

Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction., PMID:31678076

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b., PMID:31147461

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants., PMID:30923526

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering., PMID:30692120

The Complement System of Agnathans., PMID:29967624

Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance., PMID:29795138

A novel C-type lectin from the sea cucumber Apostichopus japonicus (AjCTL-2) with preferential binding of d-galactose., PMID:29772373

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement., PMID:29449492

Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model., PMID:29395422

Structure of the C1r-C1s interaction of the C1 complex of complement activation., PMID:29311313

Broad Susceptibility of Nucleolar Proteins and Autoantigens to Complement C1 Protease Degradation., PMID:29070672

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions., PMID:28596769

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis., PMID:28275265

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation., PMID:27663685

The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena., PMID:26987526

Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating., PMID:26561549

KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking., PMID:26321090

C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins., PMID:26231209

Allosteric activation of ADAMTS13 by von Willebrand factor., PMID:25512528

TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2., PMID:25359215

Peptide inhibitor of complement c1, a novel suppressor of classical pathway activation: mechanistic studies and clinical potential., PMID:25202312

Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model., PMID:25191939

An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate., PMID:25174509

Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria., PMID:25034232

Alloantibody to a Bw4 epitope in a Bw4+B*27: 05 patient., PMID:24914571

Complement component C3 activation: the leading cause of the prozone phenomenon affecting HLA antibody detection on single-antigen beads., PMID:24621535

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