Catalog No.
PHB86201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human F8 (Phe2253-Glu2346).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
AHF,Procoagulant component,Coagulation factor VIII,Antihemophilic factor,F8C,F8
Concentration
2.71 mg/ml
Purification
Purified by antigen affinity column.
Accession
P00451
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
An IL-7 fusion protein targeting EDA fibronectin upregulates TCF1 on CD8+ T-cells, preferentially accumulates to neoplastic lesions, and boosts PD-1 blockade., PMID:39142716
Extra domain A-containing fibronectin in pulmonary hypertension and treatment effects of a function-blocking antibody., PMID:39023231
Engineering a cell-penetrating hyperstable antibody scFv(Ras) - An extraordinary approach to cancer therapeutics., PMID:34738045
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin., PMID:34174417
Therapeutic Evaluation of Antibody-Based Targeted Delivery of Interleukin 9 in Experimental Pulmonary Hypertension., PMID:33801620
A Novel Antibody-IL15 Fusion Protein Selectively Localizes to Tumors, Synergizes with TNF-based Immunocytokine, and Inhibits Metastasis., PMID:33632875
Antibody-based delivery of interleukin-9 to neovascular structures: Therapeutic evaluation in cancer and arthritis., PMID:33475433
Antibody-mediated delivery of LIGHT to the tumor boosts natural killer cells and delays tumor progression., PMID:33404287
Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions., PMID:33210556
FVIII Immunogenicity-Bioinformatic Approaches to Evaluate Inhibitor Risk in Non-severe Hemophilia A., PMID:32849511
A single-valent long-acting human CD47 antagonist enhances antibody directed phagocytic activities., PMID:32583154
Antibody-Mediated Delivery of VEGFC Ameliorates Experimental Chronic Colitis., PMID:32259068
Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation., PMID:31348785
Targeted delivery of calreticulin to ED-A fibronectin leads to tumor-growth retardation., PMID:30579890
F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach., PMID:30550295
Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation., PMID:30518687
Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine., PMID:30327303
Potentiation of PD-L1 blockade with a potency-matched dual cytokine-antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains., PMID:29971465
Targeting the extradomain A of fibronectin allows identification of vascular resistance to antiangiogenic therapy in experimental glioma., PMID:29963235
Novel antibody-cytokine fusion proteins featuring granulocyte-colony stimulating factor, interleukin-3 and interleukin-4 as payloads., PMID:29438784
Antibody-based targeted delivery of interleukin-4 synergizes with dexamethasone for the reduction of inflammation in arthritis., PMID:29365185
Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12., PMID:27515704
Antibody-Based Targeted Delivery of Interleukin-22 Promotes Rapid Clinical Recovery in Mice With DSS-Induced Colitis., PMID:27482975
Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis., PMID:26919786
Pharmacological concentrations of recombinant factor VIIa restore hemostasis independent of tissue factor in antibody-induced hemophilia mice., PMID:26727350
Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody-Drug Conjugates., PMID:26294742
Targeted delivery of interleukin-10 to chronic cardiac allograft rejection using a human antibody specific to the extra domain A of fibronectin., PMID:26056964
Alternatively Spliced EDA Domain of Fibronectin Is a Target for Pharmacodelivery Applications in Inflammatory Bowel Disease., PMID:25993691
The Targeted Delivery of Interleukin 4 Inhibits Development of Endometriotic Lesions in a Mouse Model., PMID:25850899
The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity., PMID:25722088
A chemically defined trifunctional antibody-cytokine-drug conjugate with potent antitumor activity., PMID:25205656
Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation., PMID:25190364
Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis., PMID:25092334
Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy., PMID:24893857
Tumor-targeting properties of novel immunocytokines based on murine IL1β and IL6., PMID:24795343
The dose-dependent tumor targeting of antibody-IFNγ fusion proteins reveals an unexpected receptor-trapping mechanism in vivo., PMID:24795141
Antibody-based delivery of IL2 and cytotoxics eradicates tumors in immunocompetent mice., PMID:24759429
Tumor targeting properties of antibody fusion proteins based on different members of the murine tumor necrosis superfamily., PMID:24384233
Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse., PMID:24289726
Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia., PMID:24005158
The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity., PMID:23887603
The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer., PMID:23818211
Selective imaging of chronic cardiac rejection using a human antibody specific to the alternatively spliced EDA domain of fibronectin., PMID:23701854
Tumor-targeting antibody-anticalin fusion proteins for in vivo pretargeting applications., PMID:23350721
A critical evaluation of the tumor-targeting properties of bispecific antibodies based on quantitative biodistribution data., PMID:22972762
The antibody-based delivery of interleukin-12 to the tumor neovasculature eradicates murine models of cancer in combination with paclitaxel., PMID:22693354
Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts., PMID:22392081
Immunocytokines: a novel class of potent armed antibodies., PMID:22289353
Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome., PMID:22158488
The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate., PMID:22052195
For research use only. Not for human or drug use.
