African Swine Fever Virus (ASFV)
Viral Structure, Key Antigen Targets and Research Applications
ASFV particle structure (DOI: 10.1016/j.immuno.2022.100019)
Overview of ASFV
African Swine Fever Virus (ASFV) is a large, enveloped, double-stranded DNA virus belonging to the family Asfarviridae. It causes African swine fever (ASF), a highly contagious and often fatal disease affecting domestic pigs and wild suids. ASFV infection can result in severe economic losses and remains a major challenge for the global swine industry.
ASFV has a large linear DNA genome that encodes a broad range of structural and non-structural proteins involved in viral entry, replication, assembly, host interaction, and immune evasion. Due to its complex biology and extensive immune evasion mechanisms, ASFV research focuses on multiple viral proteins rather than a single dominant target.
This complexity is reflected in the wide range of ASFV antigens studied, including p72, p54, p30, p17, and CD2v (EP402R), each playing distinct roles in viral infection and host interaction.
ASFV Structure
ASFV is characterized by a complex multilayered virion structure. From the outside inward, the mature virion contains a lipid envelope, outer membrane, capsid, inner membrane, and a central core containing the viral genome. This complex architecture is closely associated with the diverse functions of ASFV proteins. Structural proteins contribute to virion assembly and stability, while membrane-associated and non-structural proteins participate in viral entry, intracellular replication, host-cell interactions, and immune modulation.
Key ASFV Research Targets
Key Research Targets
| Target | Key Features | Research Applications |
|---|---|---|
| p72 / B646L | Major capsid protein; highly immunogenic | Antigen characterization, serology, antibody and vaccine research |
| p54 / E183L | Envelope-associated protein involved in viral entry | Antigen studies, antibody research, vaccine development |
| p30 / CP204L | Early-expressed, highly immunogenic protein | Infection studies, antigen detection, immune response research |
| p17 / D117L | Inner membrane-associated protein | Viral assembly, replication, vaccine and antibody research |
| CD2v / EP402R | Membrane protein involved in host interaction and immune modulation | Virulence studies, antibody research, vaccine development |
Citation
AntibodySystem ASFV products have been cited in peer-reviewed publications, supporting ASFV antigen research, vaccine studies, and immunological analysis.
| DOI / PMID | Cat. No. | Product Name |
|---|---|---|
| PMID: 41577679 | YVV16001, YVV05901, YVV38601 | Recombinant ASFV p54/pE183L Protein, N-His; Recombinant ASFV EP402R Protein, N-His; Recombinant ASFV p17/D117L Protein, N-His-KSI |
The cited study investigated a recombinant vaccinia virus-based ASFV vaccine expressing multiple ASFV antigens, including p54, CD2v, p17, p72, p30, and other viral proteins. The vaccine induced both humoral and cellular immune responses, and 4 of 6 vaccinated pigs survived a lethal genotype II ASFV challenge, highlighting the importance of multi-antigen approaches in ASFV vaccine research.
AntibodySystem ASFV Research Products
ASFV Antigens
| Cat. No. | Product Name |
|---|---|
| YVV16001 | Recombinant ASFV p54/pE183L Protein, N-His |
| YVV05901 | Recombinant ASFV EP402R Protein, N-His |
| YVV38601 | Recombinant ASFV p17/D117L Protein, N-His-KSI |
ASFV Antibodies
AntibodySystem provides antibodies targeting multiple ASFV proteins to support studies of viral antigens, host–virus interactions, immune responses, and vaccine development.
| Cat. No. | Product Name |
|---|---|
| PVV05901 | Anti-ASFV EP402R Polyclonal Antibody |
| PVV06101 | Anti-ASFV p72/B646L Polyclonal Antibody |
| PVV39401 | Anti-ASFV p12/PO61R Polyclonal Antibody |
| PVV37401 | Anti-ASFV CP312R Polyclonal Antibody |
| PVV44901 | Anti-ASFV B602L Polyclonal Antibody |
| PVV02601 | Anti-Polyprotein pp62/Ba71V-94/ASFV-p15 Polyclonal Antibody |
| PVV02602 | Anti-Polyprotein pp62/Ba71V-94/ASFV-p35 Polyclonal Antibody |
| PVY00090 | Anti-ASFV K205R Polyclonal Antibody |
AntibodySystem's ASFV research portfolio covers a broad range of viral targets, supporting research on ASFV structure, infection mechanisms, antigenicity, immune responses, and vaccine development.
AntibodySystem — Reliable Reagents for ASFV Research
AntibodySystem provides high-quality recombinant proteins, antibodies, and immunoassay reagents to support ASFV antigen characterization, antibody screening, vaccine studies, immune response analysis, and assay development.
