Catalog No.
YHF96001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala4770-Ala5169
Predicted molecular weight
44.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02817
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mucin-2, MUC-2, Intestinal mucin-2, MUC2, SMUC
MUC2 and related bacterial factors: Therapeutic targets for ulcerative colitis. PMID: 34902790
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. PMID: 18806221
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. PMID: 16831596
Mucin 2 (MUC2) promoter characterization: an overview. PMID: 30218241
Consequence of distinctive expression of MUC2 in colorectal cancers: How much is actually bad? PMID: 34139275
Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury. PMID: 32659381
Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. PMID: 29967641
Rare minisatellite alleles of MUC2-MS8 influence susceptibility to rectal carcinoma. PMID: 34436741
DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation. PMID: 33559155
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. PMID: 20615996
Somatostatin stimulates colonic MUC2 expression through SSTR5-Notch-Hes1 signaling pathway. PMID: 31733832
The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression. PMID: 32707285
Upregulated MUC2 Is an Unfavorable Prognostic Indicator for Rectal Cancer Patients Undergoing Preoperative CCRT. PMID: 34300195
Mucin 2 (MUC2) modulates the aggressiveness of breast cancer. PMID: 30317423
The MUC2 gene product: a human intestinal mucin. PMID: 9722984
Significance of MUC2 gene methylation detection in pancreatic cancer diagnosis. PMID: 31590960
Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice. PMID: 33431704
Association of MUC2, MUC5AC and MUC5B genes with the recurrence of nasal polyps. PMID: 32742413
MUC1 and MUC2 in pancreatic neoplasia. PMID: 15113850
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress. PMID: 34494458
Exogenous NAD+ Stimulates MUC2 Expression in LS 174T Goblet Cells via the PLC-Delta/PTGES/PKC-Delta/ERK/CREB Signaling Pathway. PMID: 32283838
Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer patients. PMID: 33823840
Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with G伪q. PMID: 31906951
Roles of the gel-forming MUC2 mucin and its O-glycosylation in the protection against colitis and colorectal cancer. PMID: 23037153
Low expression of MUC2 is associated with longer disease-free survival in patients with colorectal carcinoma. PMID: 30226481
Characterization of the regulatory 5'-flanking region of bovine mucin 2 (MUC2) gene. PMID: 33730299
Fucose Ameliorates Tritrichomonas sp.-Associated Illness in Antibiotic-Treated Muc2-/- Mice. PMID: 34639039
Effect of Promoter Methylation on the Expression of Porcine MUC2 Gene and Resistance to PEDV Infection. PMID: 33996974
The Muc2 mucin coats murine Paneth cell granules and facilitates their content release and dispersion. PMID: 29698056
Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior. PMID: 18651706
Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature. PMID: 25731647
High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells. PMID: 29545196
CDX2 and Muc2 immunohistochemistry as prognostic markers in stage II colon cancer. PMID: 31121192
The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice. PMID: 30231491
Colonic MUC2 mucin regulates the expression and antimicrobial activity of 尾-defensin 2. PMID: 25921338
The Reduction-insensitive Bonds of the MUC2 Mucin Are Isopeptide Bonds. PMID: 27129250
MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa. PMID: 29069719
Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients. PMID: 31198858
MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis. PMID: 28069814
EXPRESSION OF MUC2 GLYCOPROTEIN ANTIBODY AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN BARRETT'S MUCOSA. PMID: 31363321
High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors. PMID: 29935164
MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues. PMID: 20198318
Combined EsophaCap cytology and MUC2 immunohistochemistry for screening of intestinal metaplasia, dysplasia and carcinoma. PMID: 31190949
MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. PMID: 9042800
Investigating the Relationship Between the Expression Level of Mucin Gene Cluster (MUC2, MUC5A, and MUC5B) and Clinicopathological Characterization of Colorectal Cancer. PMID: 35572847
Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases. PMID: 28122822
Leptin, MUC2 and mTOR in appendiceal mucinous neoplasms. PMID: 22236547
Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas. PMID: 33154304
Immunohistochemical Study of MUC1, MUC2 and MUC5AC Expression in Primary Breast Carcinoma. PMID: 28571146
MUC2 and MUC6 apomucins expression in human gastric neoplasm: an immunohistochemical analysis. PMID: 20878553
MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance. PMID: 27298226
Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. PMID: 24816392
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PMID: 20485566
Immunohistochemical expression profiles of MUC1 and MUC2 mucins in urothelial tumors of bladder. PMID: 30004053
MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis. PMID: 26018517
MUC2 is a molecular marker for pseudomyxoma peritonei. PMID: 12218214
Oxyresveratrol Induces Autophagy via the ER Stress Signaling Pathway, and Oxyresveratrol-Induced Autophagy Stimulates MUC2 Synthesis in Human Goblet Cells. PMID: 32150901
Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. PMID: 32222540
MUC2 is a highly specific marker of goblet cell metaplasia in the distal esophagus and gastroesophageal junction. PMID: 21602660
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. PMID: 16721789
MUC2 polymorphisms are associated with endometriosis development and infertility: a case-control study. PMID: 22417007
Small intestinal MUC2 synthesis in human preterm infants. PMID: 19246635
MUC2 expression is an adverse prognostic factor in superficial gastroesophageal adenocarcinomas. PMID: 24290360
Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3尾, Reg3纬 and angiogenin-4. PMID: 22723890
MUC2 is the prominent colonic mucin expressed in ulcerative colitis. PMID: 8707087
Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency. PMID: 29685982
MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomy. PMID: 18487999
Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro. PMID: 16504136
MUC2 expression and prevalence of high-grade dysplasia and invasive carcinoma in mixed-type intraductal papillary mucinous neoplasm of the pancreas. PMID: 24280573
MUC2 but not MUC5 expression correlates with prognosis in radically resected pancreatic cancer patients. PMID: 19587537
The silence of MUC2 mRNA induced by promoter hypermethylation associated with HBV in Hepatocellular Carcinoma. PMID: 23347460
Bile acid induces MUC2 expression and inhibits tumor invasion in gastric carcinomas. PMID: 25475007
Expression of MUC2 in gastric carcinomas and background mucosae. PMID: 17559374
Exopolysaccharides from Lactobacillus plantarum NCU116 Enhances Colonic Mucosal Homeostasis by Controlling Epithelial Cell Differentiation and c-Jun/Muc2 Signaling. PMID: 31407897
Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica. PMID: 30500860
High MUC2 expression in ovarian cancer is inversely associated with the M1/M2 ratio of tumor-associated macrophages and patient survival time. PMID: 24324582
Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis. PMID: 17203232
Expression of Pla2g2a prevents carcinogenesis in Muc2-deficient mice. PMID: 19037975
For research use only. Not for human or drug use.
