Catalog No.
PHB82301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human IL18BP (Thr31-Gly194).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:200, WB: 1:500-1:4000
Target
Interleukin-18-binding protein,IL-18BP,IL18BP,Tadekinig-alfa
Concentration
0.73mg/ml
Purification
Purified by antigen affinity column.
Accession
O95998
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity., PMID:40018678
Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18., PMID:39631848
Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects., PMID:38592331
Autoantibody-Mediated Depletion of IL-1RA in Still's Disease and Potential Impact of IL-1 Targeting Therapies., PMID:38231276
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma., PMID:38134933
Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18., PMID:37934469
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition., PMID:37469014
A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade., PMID:36875111
Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors., PMID:36510222
Interleukin-18: a biomarker with therapeutic potential in adult-onset Still's disease., PMID:35771972
Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA-Associated Vasculitis., PMID:34792864
The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion., PMID:33160017
Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection., PMID:31427887
Diabetes alters immune response patterns to acute melioidosis in humans., PMID:31032897
A whole-blood RNA transcript-based gene signature is associated with the development of CTLA-4 blockade-related diarrhea in patients with advanced melanoma treated with the checkpoint inhibitor tremelimumab., PMID:30227886
Regulatory B cells induced by pancreatic cancer cell-derived interleukin-18 promote immune tolerance via the PD-1/PD-L1 pathway., PMID:29599908
IL-1 family cytokines and soluble receptors in systemic lupus erythematosus., PMID:29422069
Elevated IL-37, IL-18 and IL-18BP serum concentrations in patients with primary Sjögren's syndrome., PMID:28057714
IL-27 induces the expression of IDO and PD-L1 in human cancer cells., PMID:26657115
Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis., PMID:26410887
The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury., PMID:26340315
PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis., PMID:25808972
Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure., PMID:24804827
Interleukin-18 mediates interleukin-1-induced cardiac dysfunction., PMID:24531812
Interleukin-18, more than a Th1 cytokine., PMID:24275602
Interleukin-18 and IL-18 binding protein., PMID:24115947
Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo., PMID:23994769
Recombinant Fc-IL-18BPc isoform inhibits IL-18-induced cytokine production., PMID:22509913
Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS., PMID:22275868
β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo., PMID:22004899
Development of isoform-specific monoclonal antibodies against human IL-18 binding protein., PMID:21087098
Immunomodulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status., PMID:20878981
Cloning and characterization of rhesus IL-18 binding protein, a natural antagonist to IL-18., PMID:20663688
[Induction of potent immune responses by recombinant fowlpox virus with deleted ORF73 or ORF214]., PMID:20560355
Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury., PMID:19164288
Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity., PMID:18092318
Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation., PMID:18064631
Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha., PMID:17360358
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor., PMID:17075045
IL-18 binding protein fusion construct delays the development of diabetes in adoptive transfer and cyclophosphamide-induced diabetes in NOD mouse., PMID:15870024
Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein., PMID:15307168
The IL-1 family and inflammatory diseases., PMID:14989423
Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure., PMID:12784053
Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF., PMID:12670445
A monoclonal antibody specific for rat IL-18BP and its application in determining serum IL-18BP., PMID:12505199
Rat interleukin-18 binding protein: cloning, expression, and characterization., PMID:12034039
IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma., PMID:11859116
Interleukin-18 binding protein in acute graft versus host disease and engraftment following allogeneic peripheral blood stem cell transplants., PMID:11798503
IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice., PMID:11698468
A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18., PMID:11497494
For research use only. Not for human or drug use.
