Catalog No.
EHJ94701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Arg844
Predicted molecular weight
93.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96RD9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FcRL5, FCRH5, FCRL5, Fc receptor homolog 5, FcRH5, CD307e, FcR-like protein 5, IRTA2, Immune receptor translocation-associated protein 2, BXMAS1, Fc receptor-like protein 5,CD307
Polymorphisms of B-lymphocyte-associated genes CD20 and FCRL5 are associated with susceptibility to autoimmune thyroid diseases., PMID:39461276
Management of Toxicities Associated with BCMA, GPRC5D, and FcRH5-Targeting Bispecific Antibodies in Multiple Myeloma., PMID:39145912
Allostimulation leads to emergence of a human B cell population with increased expression of HLA class I antigen presentation-associated molecules and the immunoglobulin receptor FcRL5., PMID:38992496
Just scratching the surface: novel treatment approaches for multiple myeloma targeting cell membrane proteins., PMID:38961233
Regulation of B-cell function and expression of CD11c, T-bet, and FcRL5 in response to different activation signals., PMID:38700378
Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma., PMID:38212320
B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection., PMID:34990486
SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease., PMID:34936684
[Bispecific antibodies in multiple myeloma]., PMID:34920804
Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria., PMID:34758841
Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma., PMID:32908921
The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China., PMID:32892204
Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis., PMID:32841219
Fc receptor-like 4 and 5 define human atypical memory B cells., PMID:32805738
Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases., PMID:32501729
FCRL5+ Memory B Cells Exhibit Robust Recall Responses., PMID:31042472
Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population., PMID:30771554
Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma., PMID:30718503
Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties., PMID:30550367
HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis., PMID:30333570
CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity., PMID:30107486
Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants., PMID:29101848
High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis., PMID:28973482
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing., PMID:28262555
Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells., PMID:27076679
B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT., PMID:27065451
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure., PMID:25993340
CD21(-/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis., PMID:24504816
Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors., PMID:23616577
Micro-volume wall-less immunoassays using patterned planar plates., PMID:23380873
FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma., PMID:22807577
Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG., PMID:22491254
Fc receptor-like 5 promotes B cell proliferation and drives the development of cells displaying switched isotypes., PMID:22028333
A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis., PMID:21937757
Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3., PMID:20626413
A single-nucleotide polymorphism marker within the FCRL5 gene and HLA-B27 positive Han Chinese ankylosing spondylitis patients., PMID:19775371
Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia., PMID:18802695
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia., PMID:18704934
FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia., PMID:18314442
Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma., PMID:17051241
Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera., PMID:16681430
Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1., PMID:16439682
Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies., PMID:15671532
IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells., PMID:11929751
BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells., PMID:11453668
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy., PMID:11290337
For research use only. Not for human or drug use.
