Catalog No.
PHB67101
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ABCA1 (Ser45-Glu271).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ATP-binding cassette transporter 1,ATP-binding cassette sub-family A member 1,Phospholipid-transporting ATPase ABCA1,ABC-1,ABCA1,ATP-binding cassette 1,Cholesterol efflux regulatory protein,ABC1,CERP
Purification
Purified by antigen affinity column.
Accession
O95477
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Ertugliflozin attenuates atherosclerosis in nondiabetic ApoE-/- mice by upregulating ABCA1 and LDLR via the PPARγ/LXRα pathway., PMID:40419168
Effects of micro- and nanoplastic exposure on macrophages: a review of molecular and cellular mechanisms., PMID:40323219
A Light-Activatable Nitric Oxide Donor for Targeted Glaucoma Therapy with Real-Time Monitoring Capabilities., PMID:40103449
NIR-II Imaging for Tracking the Spatiotemporal Immune Microenvironment in Atherosclerotic Plaques., PMID:39630481
Cholesterol Metabolism in Neurodegenerative Diseases., PMID:38842175
Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism., PMID:38162675
Reduction-responsive polymeric micelles for trans-corneal targeted delivery of microRNA-21-5p and glaucoma-specific gene therapy., PMID:37885402
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15., PMID:37468019
Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis., PMID:36988888
Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer's disease patients are associated with cognitive impairment., PMID:36788216
Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion., PMID:36537208
Recombinant Humanized IgG1 Antibody Promotes Reverse Cholesterol Transport through FcRn-ERK1/2-PPARα Pathway in Hepatocytes., PMID:36498935
Application of Micro-Western Array for Identifying Different Serum Protein Expression Profile among Healthy Control, Alzheimer's Disease Patients and Patients' Adult Children., PMID:36138870
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion., PMID:35922515
Associations of HER2 Mutation With Immune-Related Features and Immunotherapy Outcomes in Solid Tumors., PMID:35281032
Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance., PMID:34843091
ABCA1 rs1883025 and CYP4F2 rs2108622 Gene Polymorphism Association with Age-Related Macular Degeneration and Anti-VEGF Treatment., PMID:34577897
Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis., PMID:34395445
BACH1 Binding Links the Genetic Risk for Severe Periodontitis with ST8SIA1., PMID:34160287
circDENND1B Participates in the Antiatherosclerotic Effect of IL-1β Monoclonal Antibody in Mouse by Promoting Cholesterol Efflux via miR-17-5p/Abca1 Axis., PMID:33996813
The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis., PMID:33741356
Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells., PMID:33546749
Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy., PMID:33151398
ABCA1 plays an anti-inflammatory role by affecting TLR4 at the feto-maternal interface., PMID:32896556
Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner., PMID:32885302
Curcumin affects ox-LDL-induced IL-6, TNF-α, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-κB/miR33a signaling pathway., PMID:32782494
ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico., PMID:32686443
Novel milk casein-derived peptides decrease cholesterol micellar solubility and cholesterol intestinal absorption in Caco-2 cells., PMID:32113776
Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation., PMID:31970862
C-terminal of ABCA1 separately regulates cholesterol floppase activity and cholesterol efflux activity., PMID:31814539
Effects of β2/aβ2 on oxLDL-induced CD36 activation in THP-1 macrophages., PMID:31654747
Relationship between HDL Cholesterol Efflux Capacity, Calcium Coronary Artery Content, and Antibodies against ApolipoproteinA-1 in Obese and Healthy Subjects., PMID:31443207
ABCA1 and metabolic syndrome; a review of the ABCA1 role in HDL-VLDL production, insulin-glucose homeostasis, inflammation and obesity., PMID:31336517
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency., PMID:31263122
Therapeutic Intranasal Vaccine HB-ATV-8 Prevents Atherogenesis and Non-alcoholic Fatty Liver Disease in a Pig Model of Atherosclerosis., PMID:30792163
Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis., PMID:30679232
CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis., PMID:30347516
Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis - Tampere Vascular Study., PMID:30305673
Apolipoprotein B-100 peptide 210 antibody inhibits atherosclerosis by regulation of macrophages that phagocytize oxidized lipid., PMID:30018722
IL-8 negatively regulates ABCA1 expression and cholesterol efflux via upregulating miR-183 in THP-1 macrophage-derived foam cells., PMID:29703573
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters., PMID:29670629
Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis., PMID:29106519
Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells., PMID:28943268
Association of ATP-Binding Cassette Transporter A1 (ABCA1)-565 C/T Gene Polymorphism with Hypoalphalipoproteinemia and Serum Lipids, IL-6 and CRP Levels., PMID:28090279
Gene expression in obstetric antiphospholipid syndrome: a systematic review., PMID:28028299
Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages., PMID:27940374
ABCA1 (ATP-Binding Cassette Transporter A1) Mediates ApoA-I (Apolipoprotein A-I) and ApoA-I Mimetic Peptide Mobilization of Extracellular Cholesterol Microdomains Deposited by Macrophages., PMID:27758769
Alterations of membrane protein expression in red blood cells of Alzheimer's disease patients., PMID:27239515
High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacities After Infusion of MDCO-216 (Apolipoprotein A-IMilano/Palmitoyl-Oleoyl-Phosphatidylcholine) in Healthy Volunteers and Stable Coronary Artery Disease Patients., PMID:26916733
Role of Liver X Receptor in AD Pathophysiology., PMID:26720273
For research use only. Not for human or drug use.
