Catalog No.
EHD97901
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Thr43-Pro217
Predicted molecular weight
22.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P31994
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IGFR2, FCG2, Fc-gamma RII-b, CDw32, FcRII-b, IgG Fc receptor II-b, CD32, Fc-gamma-RIIb, Low affinity immunoglobulin gamma Fc region receptor II-b, FCGR2B
Human Fcγ-receptors selectively respond to C-reactive protein isoforms., PMID:40458392
Fgl2 regulates FcγRIIB+CD8+ T cell responses during infection., PMID:40197366
Macrophage-derived Fgl2 dampens antitumor immunity through regulation of FcγRIIB+CD8+ T cells in melanoma., PMID:40125553
FcγRIIB (CD32B) antibodies enhance immune responses through activating FcγRs., PMID:40089806
Fc gamma receptors activate different protein kinase C isoforms in human neutrophils., PMID:39946245
Protection of liver sinusoidal endothelial cells using different preservation solutions., PMID:39812559
A Competition-Based Strategy for the Isolation of an Anti-Idiotypic Blocking Module and Fine-Tuning for Conditional Activation of a Therapeutic Antibody., PMID:39655405
The Immunosuppressive Receptor CD32b Regulation of Macrophage Polarization and Its Implications in Tumor Progression., PMID:39273683
FGL2/FcγRIIB Signalling Mediates Arterial Shear Stress-Mediated Endothelial Cell Apoptosis: Implications for Coronary Artery Bypass Vein Graft Pathogenesis., PMID:39062880
A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia., PMID:38899695
New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes., PMID:38408113
Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding., PMID:38050338
Immunomodulatory effects of intravenous and subcutaneous immunoglobulin in chronic inflammatory demyelinating polyneuropathy: An observational study., PMID:37789648
FCGR2B as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis., PMID:37713871
FcγRIIB expressed on CD8+ T cells limits responsiveness to PD-1 checkpoint inhibition in cancer., PMID:37611081
FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab., PMID:37575254
Proteomic Analysis of Dysfunctional Liver Sinusoidal Endothelial Cells Reveals Substantial Differences in Most Common Experimental Models of Chronic Liver Diseases., PMID:37569282
Differential Efficacy From the Addition of Bortezomib to R-CHOP in Diffuse Large B-Cell Lymphoma According to the Molecular Subgroup in the REMoDL-B Study With a 5-Year Follow-Up., PMID:36972491
CIDP: Analysis of Immunomarkers During COVID-19 mRNA-Vaccination and IVIg-Immunomodulation: An Exploratory Study., PMID:36929282
The CD16 and CD32b Fc-gamma receptors regulate antibody-mediated responses in mouse natural killer cells., PMID:36822164
Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy., PMID:36685519
Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance., PMID:35963953
FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms., PMID:35858562
The Antibody Dependant Neurite Outgrowth Modulation Response Involvement in Spinal Cord Injury., PMID:35784350
Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma., PMID:35610242
Role of Fcγ receptors in HER2-targeted breast cancer therapy., PMID:34992090
Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease., PMID:34933777
Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index., PMID:34922596
The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells., PMID:34899053
Evaluation of the FCGR2B polymorphism in children with immune thrombocytopenia., PMID:34859644
Similarity and Potential Relation Between Periimplantitis and Rheumatoid Arthritis on Transcriptomic Level: Results of a Bioinformatics Study., PMID:34858391
An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability., PMID:34687301
Homogeneously high expression of CD32b makes it a potential target for CAR-T therapy for chronic lymphocytic leukemia., PMID:34530888
Prognostic significance of FCGR2B expression for the response of DLBCL patients to rituximab or obinutuzumab treatment., PMID:34323958
Lack of intrafollicular memory CD4 + T cells is predictive of early clinical failure in newly diagnosed follicular lymphoma., PMID:34267181
Subclasses of allergen-specific IgG: Serum IgG2 and IgG3 levels are not predicted by IgG1/IgG4 levels., PMID:34192382
FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene., PMID:34108956
Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension., PMID:33980031
Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway., PMID:33941321
Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu., PMID:33893391
Margetuximab: First Approval., PMID:33761116
FcγRIIB is a T cell checkpoint in antitumor immunity., PMID:33616086
Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis., PMID:33568400
FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis., PMID:33505402
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells., PMID:33446637
Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes., PMID:33424774
Yishen-tongbi decoction inhibits excessive activation of B cells by activating the FcγRIIb/Lyn/SHP-1 pathway and attenuates the inflammatory response in CIA rats., PMID:33373915
IgE and mast cells: The endogenous adjuvant., PMID:33190734
Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys., PMID:33188207
DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy., PMID:32956626
For research use only. Not for human or drug use.
