Catalog No.
EHD15401
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Ser710
Predicted molecular weight
80.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16144
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GP150, Integrin beta-4, CD104, ITGB4
The Junctional Epithelium Attachment Is Regulated by Wnt Signaling., PMID:40492573
Epithelial eversion, a collective rearrangement from apical-in to apical-out polarity, is initiated by α6β4 integrins and sustained by increased cell proliferation and anchorage-independence., PMID:40463241
Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer., PMID:40407591
Paricalcitol and hydroxychloroquine modulates extracellular matrix and enhance chemotherapy efficacy in pancreatic cancer., PMID:40386428
Lactate accumulation drives hepatocellular carcinoma metastasis through facilitating tumor-derived exosome biogenesis by Rab7A lactylation., PMID:40120799
Increased Kindlin-2 via SMURF1 Inhibition Attenuates Endothelial Permeability and Acute Lung Injury., PMID:40076507
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis., PMID:40010102
Localization of Lesions in Autoimmune Blistering Diseases Is Independent of Site-Specific Target Antigen Expression., PMID:40003627
MiR-483 targeting integrin β4 regulates the stability of intestinal barrier in turbot (Scophthalmus maximus) during pathogen infection., PMID:39984003
Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway., PMID:39873948
Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer., PMID:39792419
Gingival keratinocyte adhesion on atomic layer-deposited hydroxyapatite coated titanium., PMID:39773092
ITGB4/CD104 mediates zika virus attachment and infection., PMID:39737945
Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4., PMID:39732060
Mirror-polished ceria-stabilized zirconia/alumina nanocomposite enhances gingival junctional epithelial cell adhesion., PMID:39637939
Alterations in the microenvironment of junctional epidermolysis bullosa keratinocytes: A gene expression study., PMID:39615637
Up-regulated ITGB4 promotes hepatocellular carcinoma metastasis by activating hypoxia-mediated glycolysis and cancer-associated fibroblasts., PMID:39603378
Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study., PMID:39584991
Case Report: Alpha6 Integrin Disorder Presenting in Childhood with Nail Dysplasia and Onycholysis But No History of Fragile or Bullous Skin Changes., PMID:39583125
ITGB4/GNB5 axis promotes M2 macrophage reprogramming in NSCLC metastasis., PMID:39577216
Integrin α6β4 Upregulates PTPRZ1 Through UCHL1-Mediated Hif-1α Nuclear Accumulation to Promote Triple-Negative Breast Cancer Cell Invasive Properties., PMID:39518121
Bufotalin Induces Oxidative Stress-Mediated Apoptosis by Blocking the ITGB4/FAK/ERK Pathway in Glioblastoma., PMID:39456433
ROCK Inhibitor Enhances Neurite Outgrowth In Vitro and Corneal Sensory Nerve Reinnervation In Vivo., PMID:39436373
YKL40/Integrin β4 Axis Induced by the Interaction between Cancer Cells and Tumor-Associated Macrophages Is Involved in the Progression of High-Grade Serous Ovarian Carcinoma., PMID:39408927
ITGB4-Related pyloric atresia without epidermolysis in two siblings., PMID:39322060
The Role of Serology in the Diagnosis of Ocular Predominant Mucous Membrane Pemphigoid and the Search for an Ocular-Specific Autoantigen., PMID:39241171
The mechanism of ITGB4 in tumor migration and invasion., PMID:39169946
Congenital pyloric atresia associated with epidermolysis bullosa junctionalis: a novel lethal variant., PMID:39074943
Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK., PMID:39059397
Multifunctional and bioinspired titanium surface with multilayer nanofilms for novel dental implant applications., PMID:39036659
[Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer]., PMID:38951081
The association between integrin β4 overexpression and lymphovascular invasion in papillary thyroid cancer., PMID:38887115
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression., PMID:38831335
ITGB4 is a prognostic biomarker and correlated with lung adenocarcinoma brain metastasis., PMID:38776034
Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling., PMID:38730209
IGF2BP2 regulates the proliferation and migration of endometrial stromal cells through the PI3K/AKT/mTOR signaling pathway in Hu sheep., PMID:38727196
CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway., PMID:38602002
FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway., PMID:38587072
Involvement of BCR::ABL1 in laminin adhesion of Philadelphia chromosome-positive acute lymphoblastic leukemia through upregulation of integrin α6., PMID:38577721
YAP/TAZ-mediated regulation of laminin 332 is enabled by β4 integrin repression of ZEB1 to promote ferroptosis resistance., PMID:38508310
Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts., PMID:38476279
Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway., PMID:38475740
Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro., PMID:38474751
MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway., PMID:38375821
Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling., PMID:38332433
Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration., PMID:38320632
ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling., PMID:38281617
Integrin-associated transcriptional characteristics of circulating tumor cells in breast cancer patients., PMID:38250718
Surface modification affects human gingival epithelial cell behavior on polyetheretherketone surfaces., PMID:38246630
Integrated Analysis of DNA Methylation and Gene Expression Profiles in a Rat Model of Osteoarthritis., PMID:38203768
For research use only. Not for human or drug use.
