Catalog No.
EHA70801
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Asp74-Val240
Predicted molecular weight
46.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43557
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Herpes virus entry mediator ligand, LIGHT, CD258, HVEM-L, HVEML, TNFSF14, Tumor necrosis factor ligand superfamily member 14, Herpesvirus entry mediator ligand
Targeting B and T lymphocyte attenuator in cancer immunotherapy., PMID:40480574
Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis., PMID:40127640
Clinical Significance of TNFSF14/LIGHT and CD160 in Gastric Cancer and Peptic Ulcer Dyspepsia., PMID:39205564
Multilayered Computational Framework for Designing Peptide Inhibitors of HVEM-LIGHT Interaction., PMID:38958133
Systemic inflammatory cytokine profiles in patients with gout during flare, intercritical and treat-to-target phases: TNFSF14 as new biomarker., PMID:38373842
TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study., PMID:38235898
Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis., PMID:37722959
LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells., PMID:37552689
High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome., PMID:36917420
Elevated Levels of the Cytokine LIGHT in Pediatric Crohn's Disease., PMID:36688686
Comprehensive characterization of TNFSF14/LIGHT with implications in prognosis and immunotherapy of human gliomas., PMID:36341396
A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion., PMID:35987137
LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade., PMID:35817517
Hepatic stellate cell mediates transcription of TNFSF14 in hepatocellular carcinoma cells via H2S/CSE-JNK/JunB signaling pathway., PMID:35292636
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome., PMID:34871182
The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts., PMID:34838790
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160., PMID:34709351
Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation., PMID:34359880
Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility., PMID:34353742
Abundant TNF-LIGHT expression in the airways of patients with asthma with persistent airflow limitation: Association with nitrative and inflammatory profiles., PMID:34244107
The tumor necrosis factor family molecules LIGHT and lymphotoxins in sinus mucosa of patients with chronic rhinosinusitis with or without nasal polyps., PMID:34083106
LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells., PMID:33606781
LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells., PMID:33594067
Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients., PMID:33542721
Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage., PMID:33492677
LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis., PMID:33045563
Efficient Expansion of Human Granzyme B-Expressing B Cells with Potent Regulatory Properties., PMID:32948686
LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-κB pathway., PMID:32881263
Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS., PMID:32817460
Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160., PMID:32795404
The impact of TNFSF14 on prognosis and immune microenvironment in clear cell renal cell carcinoma., PMID:32725578
Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype., PMID:32712105
Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents., PMID:32635185
TNFSF14: LIGHTing the Way for Effective Cancer Immunotherapy., PMID:32499782
Identification of immunologic subtype and prognosis of GBM based on TNFSF14 and immune checkpoint gene expression profiling., PMID:32310827
TNFSF14, a novel target of miR-326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation., PMID:32118359
Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury., PMID:32059364
Neonatal Antibiotic Treatment Is Associated With an Altered Circulating Immune Marker Profile at 1 Year of Age., PMID:31998285
LIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss., PMID:31990039
LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients., PMID:31826304
Unique Sjögren's syndrome patient subsets defined by molecular features., PMID:31497844
Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia., PMID:31300808
The Absence of Lymphotoxin-α, a Herpesvirus Entry Mediator (HVEM) Ligand, Affects Herpes Simplex Virus 1 Infection In Vivo Differently than the Absence of Other HVEM Cellular Ligands., PMID:31142672
Circulating TNFSF14 (Tumor Necrosis Factor Superfamily 14) Predicts Clinical Outcome in Patients With Stable Coronary Artery Disease., PMID:30943772
LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens., PMID:30405638
Green light and light stress in moth: influence on antioxidant enzymes in the oriental armyworm, Mythimna separata (Lepidoptera: Noctuidae)., PMID:30328544
Shedding Light on the Shade: How Nurseries Protect Their Children from Ultraviolet Radiation., PMID:30134509
Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria., PMID:29952668
Investigation of Plasma Inflammatory Profile in Diabetic Patients With Abdominal Aortic Aneurysm: A Pilot Study., PMID:29940819
TNFSF14 inhibits melanogenesis via NF-kB signaling in melanocytes., PMID:29730385
For research use only. Not for human or drug use.
