Catalog No.
EHA06701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Lys14-Arg126
Predicted molecular weight
41.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00238
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BMP type-1B receptor, BMPR1B, CDw293, BMPR-1B, Bone morphogenetic protein receptor type-1B
Acromesomelic Dysplasia With Homozygosity for a Likely Pathogenic BMPR1B Variant: Postaxial Polydactyly as a Novel Clinical Finding., PMID:39441036
Congenital hallux valgus occurs in Fibrodysplasia Ossificans Progressiva and BMPR1B-associated dysplasia: an important distinction., PMID:38879467
Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway., PMID:38703029
A repertoire of single nucleotide polymorphisms (SNPs) of major fecundity BMPR1B gene among 75 sheep breeds worldwide., PMID:38401385
A novel variant in BMPR1B causes acromesomelic dysplasia Grebe type in a consanguineous Moroccan family: Expanding the phenotypic and mutational spectrum of acromesomelic dysplasias., PMID:37524292
Screening for causative mutations in ovine BMPR1B and BMP15 genes and their homologous fragments in human., PMID:37455267
PCTAIRE Protein Kinase 1 (PCTK1) Suppresses Proliferation, Stemness, and Chemoresistance in Colorectal Cancer through the BMPR1B-Smad1/5/8 Signaling Pathway., PMID:37373155
BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study., PMID:35501253
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway., PMID:35404759
METTL3-mediated LINC00657 promotes osteogenic differentiation of mesenchymal stem cells via miR-144-3p/BMPR1B axis., PMID:35192037
Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis., PMID:35034853
BMPR1B gene in brachydactyly type 2-A family with de novo R486W mutation and a disease phenotype., PMID:33486847
CDMP1 promotes type II collagen and aggrecan synthesis of nucleus pulposus cell via the mediation of ALK6., PMID:33215411
BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation., PMID:32764110
Eukaryotic expression, Co-IP and MS identify BMPR-1B protein-protein interaction network., PMID:32471519
Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice., PMID:32106289
The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission., PMID:32001529
BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency., PMID:31769494
Accumulation of rare coding variants in genes implicated in risk of human cleft lip with or without cleft palate., PMID:31063268
Genetic Prediction of Atherosclerosis - Significance of Polymorphisms in Bone Morphogenetic Protein Signaling Molecule Genes., PMID:30814434
Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (BMPR1B) Gene Are Predictive for Carotid Intima-Media Thickness., PMID:30713213
Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes., PMID:30503129
Biological effects of BMP7 on small-cell lung cancer cells and its bone metastasis., PMID:30015928
Correlating interfacial water dynamics with protein-protein interaction in complex of GDF-5 and BMPRI receptors., PMID:29890403
Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility., PMID:29581481
A novel homozygous variant in BMPR1B underlies acromesomelic dysplasia Hunter-Thompson type., PMID:29322508
Downregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma., PMID:29192325
Immature CML cells implement a BMP autocrine loop to escape TKI treatment., PMID:29138221
The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development., PMID:29113831
MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR2) -Promoted Cancer Cell Migration., PMID:28990808
Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification., PMID:28716575
Statin Use After Diagnosis of Colon Cancer and Patient Survival., PMID:28512021
New mutations in non-syndromic primary ovarian insufficiency patients identified via whole-exome sequencing., PMID:28505269
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans., PMID:28460577
BMPR1B mutation causes Pierre Robin sequence., PMID:28418932
Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling., PMID:28357470
[Polymorphism analysis of MTHFR，BMPR1B and TYMS in microtia]., PMID:29871275
MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b., PMID:28214897
A Selective Cell Population from Dermis Strengthens Bone Regeneration., PMID:28170187
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2., PMID:27720933
Inhibitory Effect of Bone Morphogenetic Protein 4 in Retinal Pigment Epithelial-Mesenchymal Transition., PMID:27586653
Genetics of human isolated acromesomelic dysplasia., PMID:26926249
Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility., PMID:26805635
Low expression of BMPRIB indicates poor prognosis of breast cancer and is insensitive to taxane-anthracycline chemotherapy., PMID:26684357
Long-Range Communication Network in the Type 1B Bone Morphogenetic Protein Receptor., PMID:26562759
A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia., PMID:26105076
Novel mutation in the BMPR1B gene (R486L) in a Polish family and further delineation of the phenotypic features of BMPR1B-related brachydactyly., PMID:25776145
Two novel disease-causing variants in BMPR1B are associated with brachydactyly type A1., PMID:25758993
Effects of recombinant human bone morphogenetic protein 7 (rhBMP-7) on the behaviour of oral squamous cell carcinoma: a preliminary in vitro study., PMID:25480012
Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro., PMID:25262542
For research use only. Not for human or drug use.
