Catalog No.
PHB21701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NR1I2 (Ser130-Ile431).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
NR1I2,SXR,PXR,Steroid and xenobiotic receptor,Orphan nuclear receptor PXR,Nuclear receptor subfamily 1 group I member 2,Pregnane X receptor,Orphan nuclear receptor PAR1
Purification
Purified by antigen affinity column.
Accession
O75469
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response., PMID:40205519
Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status., PMID:36113565
Transcription Factors and Regulators Pathway-focused Genes Expression Analysis in Patients with Different Forms of Thyroid Pathology., PMID:35176984
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo., PMID:34386326
IL-6 downregulates hepatic carboxylesterases via NF-κB activation in dextran sulfate sodium-induced colitis., PMID:34217990
Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration-Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation., PMID:34045957
The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice., PMID:33398415
Enrichment-free High-throughput Liquid Chromatography-Multiple-Reaction Monitoring Quantification of Cytochrome P450 Proteins in Plated Human Hepatocytes Direct from 96-Well Plates Enables Routine Protein Induction Measurements., PMID:32350061
Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway., PMID:31719637
DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene., PMID:30908543
Effect of tacrolimus dispositional genetics on acute rejection in the first 2 weeks and estimated glomerular filtration rate in the first 3 months following kidney transplantation., PMID:30489455
Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients., PMID:27334415
Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells., PMID:26232425
Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients., PMID:25712183
Genome-wide discovery of drug-dependent human liver regulatory elements., PMID:25275310
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4., PMID:25065623
Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis., PMID:24368568
Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes., PMID:24144795
Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway., PMID:23536316
Renal efflux transporter expression in pregnant mice with Type I diabetes., PMID:22531820
Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer., PMID:22050110
B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR., PMID:21436254
Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis., PMID:21359593
The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression., PMID:21146967
Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats., PMID:20954081
Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver., PMID:19562681
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice., PMID:19407337
Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells., PMID:18390843
CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist., PMID:18310472
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines., PMID:17279585
Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization., PMID:16246268
Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT)., PMID:16219912
Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice., PMID:15860574
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver., PMID:15347657
Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor., PMID:14978251
Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis., PMID:12883478
Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism., PMID:12756208
Induction of CYP2C genes in human hepatocytes in primary culture., PMID:11181490
Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats., PMID:10640517
For research use only. Not for human or drug use.
