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Research Grade Anti-Human FGF21 (ARX618)

Catalog #:   DHJ67202 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ67202

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG

Clonality

Monoclonal

Target

FGF21, Fibroblast growth factor 21, FGF-21

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NSA1

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

ARX618

Clone ID

ARX618

Data Image
References

Association of neurobiological and immune serum biomarkers with Toxoplasma gondii infection in patients with schizophrenia., PMID:40397143

Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis., PMID:40209593

First-in-Human Study on Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of HEC88473, a Novel Dual GLP-1 and FGF21 Receptor Agonist in Healthy and Obese Chinese Subjects., PMID:40175670

Advances in Oral Biomacromolecule Therapies for Metabolic Diseases., PMID:40006605

Establishment of a Direct Competitive ELISA for Camel FGF21 Detection., PMID:40005931

Clinical Trial: A Phase 2b Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-Cirrhotic MASH., PMID:39984821

Fibroblast growth factor 21 alleviated atopic march by inhibiting the differentiation of type 2 helper T cells., PMID:39798471

Novel FGF21 analogues through structure-based optimization for therapeutic development., PMID:39719877

Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial., PMID:39718468

Construction and Expression of Fc-FGF21 by Different Expression Systems and Comparison of Their Similarity and Difference with Efruxifermin by In Vitro and In Vivo Studies., PMID:39699797

Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity., PMID:39542224

Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice., PMID:39463193

Effects of Vitamin D-3 Supplementation During Pregnancy and Lactation on Maternal and Infant Biomarkers of Environmental Enteric Dysfunction, Systemic Inflammation, and Growth: A Secondary Analysis of a Randomized Controlled Trial., PMID:39278411

Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis., PMID:39226764

Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers., PMID:39156689

Brown adipose tissue-derived FGF21 mediates the cardioprotection of dexmedetomidine in myocardial ischemia/reperfusion injury., PMID:39112671

Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model., PMID:38805968

BV2 Membrane-Coated PEGylated-Liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy., PMID:38513154

Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study., PMID:38447814

Current status and future perspectives of FGF21 analogues in clinical trials., PMID:38423900

Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells., PMID:38309268

Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation., PMID:38271099

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study., PMID:38172101

A specific nanobody-based affinity chromatography resin as a platform for small ubiquitin-related modifier fusion protein purification., PMID:38006661

Inflammatory related plasma proteins involved in acute preschool wheeze., PMID:38006384

Leptin Reduction as a Required Component for Weight Loss., PMID:37935033

Role of serum cytokines in the prediction of heart failure in patients with coronary artery disease., PMID:37608687

Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases., PMID:37374349

Loss of epidermal glucocorticoid receptor protects against whole body metabolic dysfunction upon chronic corticosterone treatment., PMID:37364709

Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin., PMID:37141854

Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia., PMID:37127348

The effect of fibroblast growth factor 21 on a mouse model of bovine viral diarrhea., PMID:36968461

A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis., PMID:36644237

Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration., PMID:36643635

The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project., PMID:36529369

Safety, pharmacokinetics, and pharmacodynamics of pegozafermin in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 1b/2a multiple-ascending-dose study., PMID:36521501

Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes., PMID:36331598

Biomarkers of environmental enteric dysfunction and adverse birth outcomes: An observational study among pregnant women living with HIV in Tanzania., PMID:36130475

Fibroblast Growth Factor-Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications., PMID:36100222

Capillary Electrophoresis-Mass Spectrometry (CE-MS) by Sheath-Flow Nanospray Interface and Its Use in Biopharmaceutical Applications., PMID:35941476

Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis., PMID:35931383

X-linked hypophosphatemia, obesity and arterial hypertension: data from the XLH21 study., PMID:35758999

Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19., PMID:35479098

Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice., PMID:34957498

Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice., PMID:34675003

Lower melanoma pulmonary metastatic burden in obese mice: role of FGF-21., PMID:34524221

Risk-Predictive and Diagnostic Biomarkers for Colorectal Cancer; a Systematic Review of Studies Using Pre-Diagnostic Blood Samples Collected in Prospective Cohorts and Screening Settings., PMID:34503217

ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia., PMID:34485611

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial., PMID:34239138

Rat Milk and Plasma Immunological Profile throughout Lactation., PMID:33920419

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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For research use only. Not for human or drug use.

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Research Grade Anti-Human FGF21 (ARX618) [DHJ67202]
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