Catalog No.
DHB88401
Description
Tenecteplase (TNKase, DP00031) is a recombinant and site directed mutant version of human tissue plasminogen activator (tPA, EC 3.4.21.68) and is a member of the serine protease.
Expression system
Mammalian Cells
Species reactivity
Human
Target
t-plasminogen activator, tPA, t-PA, Reteplase, Tissue-type plasminogen activator, Alteplase, PLAT
Concentration
1.8 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Ion Exchange Chromatography.
Accession
P00750
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
315mM Arginine, pH 7.3, 173mM H3PO4, 0.043% Tween 20.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Tnkase, Dp00031, TNK-tPA, Metalyse, CAS: 191588-94-0
Clone ID
Tenecteplase
Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): Protocol for a randomized-controlled trial., PMID:40509553
Adjunctive intra-arterial thrombolysis after successful endovascular thrombectomy for large vessel occlusion: Meta-analysis of outcomes, dosage, and patient selection., PMID:40506219
Effect of Time Delay on Reperfusion After Tenecteplase in an Extended Time Window: Analysis From the CHABLIS-T Trials., PMID:40497495
Tenecteplase Beyond 4.5 Hours in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials., PMID:40494577
Letter to the editor, regarding "Transition from alteplase to tenecteplase for treatment of acute ischemic stroke in a rural stroke network of the Midwest: Planning, execution, safety, and outcomes" recently published by Loggini., PMID:40482545
Stroke thrombectomy of a mural thrombus in a severe dolichoectatic basilar artery with double parallel large stent retrievers and Sofia 88., PMID:40473383
Tenecteplase in acute ischemic stroke: a new era in thrombolysis., PMID:40451189
Twist of Fate: Life-Threatening SMA Thrombosis Caused by Mesenteric Torsion Post-Roux-en-Y Weight Loss., PMID:40443859
Fibrinogen Depletion Coagulopathy and Hemorrhagic Transformation in Acute Ischemic Stroke Treated With Bridging Therapy., PMID:40400131
Intravenous Tenecteplase before Thrombectomy in Stroke., PMID:40396577
Reviewer comment on Halabi et al. "Safety and real-world effectiveness in the transition from Alteplase to Tenecteplase for stroke treatment"., PMID:40396409
Reviewer Comment on Halabi et al.: "Safety and real-world effectiveness in the transition from Alteplase to Tenecteplase for stroke treatment"., PMID:40396368
Stroke-Like Symptoms Status-Post Tenecteplase (TNK) Administration: A Rare Case of Hemiplegic Migraine., PMID:40342433
Advances in treatments for acute ischemic stroke., PMID:40335091
Thrombolysis for acute ischaemic stroke: development and update., PMID:40331091
Efficacy and safety of tenecteplase administration in extended time window for acute ischemic stroke: An updated meta-analysis of randomized controlled trials., PMID:40324546
Acute Ischemic Stroke in a Marathon Runner: Last Known Well at Mile 22 Case Report., PMID:40323301
Switch to tenecteplase for intravenous thrombolysis in stroke patients: experience from a German high-volume stroke center., PMID:40320554
Early diagnosis and rapid thrombectomy with stent placement in distal vertebral artery stenosis (Mori Type C) with mild symptoms., PMID:40293218
Retrospective review of thrombolytic use for cardiac arrest due to suspected pulmonary embolism., PMID:40279831
Efficacy and safety of intra-arterial thrombolysis after endovascular reperfusion for acute ischemic stroke: a systematic review and meta-analysis of randomized trials., PMID:40277355
Endovascular thrombectomy with versus without intravenous thrombolysis for acute ischaemic stroke., PMID:40271574
Head-to-Head: Recombinant Human Prourokinase Versus Intravenous Thrombolytics in Acute Ischemic Stroke Within 4.5 Hours - A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials., PMID:40270089
In brief: A new indication for tenecteplase (TNKase)., PMID:40261318
Adjunctive intra-arterial thrombolysis following successful endovascular reperfusion in acute ischemic stroke: a systematic review and meta-analysis of seven randomized controlled trials., PMID:40246769
Tenecteplase is here: navigating the shift of a stroke thrombolytic in the United States prior to FDA approval: a mini-review on rationale, barriers, and pathways., PMID:40242615
Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO-2 Trial., PMID:40240937
Tenecteplase for Minor Stroke: Does Sex Matter?, PMID:40240931
Sex differences in outcomes and time to treatment in stroke patients treated with tenecteplase., PMID:40237595
Risk of intracerebral haemorrhage with tenecteplase versus alteplase in acute ischaemic stroke: a meta-analysis., PMID:40208343
CuratED: The emergency medicine pharmacotherapy literature of 2024., PMID:40203497
Tenecteplase compared to alteplase before mechanical thrombectomy enhances 1-h recanalization and reduces disability in large-vessel occlusion., PMID:40202611
Tenecteplase-assisted transapical drainage of tuberculous pyopericardium., PMID:40198827
Hemifacial Spasms or Focal Aware Seizures: The Role of Video-EEG., PMID:40196104
Synchronous Acute Ischemic Stroke and Acute Myocardial Infarction: A Case Report., PMID:40190953
Response to Letter Regarding Article, "Optimizing Acute Ischemic Stroke Outcomes: The Role of Tenecteplase Before Mechanical Thrombectomy"., PMID:40189421
Tenecteplase versus alteplase for intravenous thrombolysis of acute ischemic stroke patients with large-vessel occlusion: a systematic review and meta-analysis., PMID:40177405
Comparison of the Novel Thrombolytic Constitutively Active ADAMTS13 With Clinical Thrombolytics in a Murine Stroke Model., PMID:40171654
Rise and restore: the role of cerebral angiogram with mechanical thrombectomy in the case of cerebral vascular accident and a wake-up stroke: a case report., PMID:40170093
Persistent Tissue-Level Hypoperfusion (No-Reflow) Negates the Clinical Benefit of Successful Thrombectomy., PMID:40160088
Tenecteplase versus alteplase in patients with acute ischemic stroke: An updated meta-analysis of randomized controlled trials., PMID:40157656
Tenecteplase for ischemic stroke at 4.5 to 24 hours without thrombectomy: a cost-utility analysis from the perspective of Chinese healthcare system., PMID:40129864
Safety, Functional Disability, Healthcare Utilization, and Quality-of-Life Outcomes in Elderly Receiving Alteplase and Tenecteplase: A Secondary Analysis From the AcT Trial., PMID:40123483
Influence of impaired renal function on the outcomes of patients with acute ischaemic stroke treated with intravenous tenecteplase and alteplase: a post hoc analysis of the TRACE-2 trial., PMID:40102020
Intravenous thrombolysis with tenecteplase versus alteplase in acute ischemic stroke tandem occlusions: a systematic review and meta-analysis of current available literature., PMID:40082388
Transitioning to Intravenous Tenecteplase for the Treatment of Acute Ischemic Stroke., PMID:40072440
Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke., PMID:40072434
Navigating the waters of acute minor stroke therapies: a systematic review and network meta-analysis., PMID:40010568
Reduced-Dose Tenecteplase in High-Risk Pulmonary Embolism., PMID:39988495
Impact of prior antiplatelet therapy on safety and efficacy of alteplase in acute ischemic stroke: a systematic review and meta-analysis., PMID:39985653
For research use only. Not for human or drug use.
