Catalog No.
DHK29201
Expression system
Mammalian Cells
Species reactivity
Human
Isotype
Fusion - [FZD8 (frizzled class receptor 8, frizzled family receptor 8, Frizzled-8)]2 - IGHG1 Fc (Fragment constant)
Target
Wnt ligands
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
FZD8-Fc,Frizzled8 Fc,OMP-54F28, CAS: 1391727-24-4
Clone ID
Ipafricept
Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer., PMID:32694153
A phase 1b dose escalation study of ipafricept (OMP54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer., PMID:31174889
Hepatocellular Carcinoma: Etiology and Current and Future Drugs., PMID:31024205
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)., PMID:29786110
A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors., PMID:28954784
Molecular genetics and targeted therapy of WNT-related human diseases (Review)., PMID:28731148
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death., PMID:28691093
For research use only. Not for human or drug use.
