Catalog No.
DHF19820
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
Claudin-18, CLDN18
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P56856
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
SPX-101, SPX 101, SPX101
Clone ID
SPX-101
First clinical trials of novel ENaC targeting therapy, SPX-101, in healthy volunteers and adults with cystic fibrosis., PMID:31302339
SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration., PMID:30190268
SPX-101 is stable in and retains function after exposure to cystic fibrosis sputum., PMID:29936069
Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration., PMID:29890087
Nonclinical safety assessment of SPX-101, a novel peptide promoter of epithelial sodium channel internalization for the treatment of cystic fibrosis., PMID:28984146
SPX-101 Is a Promising and Novel Nebulized ENaC Inhibitor., PMID:28609635
SPX-101 Is a Novel Epithelial Sodium Channel-targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport., PMID:28481660
For research use only. Not for human or drug use.
