Catalog No.
YHK29101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln2206-Lys2426
Predicted molecular weight
27.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92508
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Piezo-type mechanosensitive ion channel component 1, FAM38A, PIEZO1, Protein FAM38A, KIAA0233, Mib, Membrane protein induced by beta-amyloid treatment
Regulation of PIEZO1 channel force sensitivity by interblade handshaking., PMID:40512861
The Piezo1/Extracellular Signal-Regulated Kinase Signal Pathway Regulates Proliferation and Migration of Aortic Vascular Smooth Muscle Cells and Participates in Thoracic Aortic Aneurysm., PMID:40500623
Impact of Abnormal Mechanical Stress on Chondrocyte Death in Osteoarthritis., PMID:40493524
The role of Piezo1 in cardiovascular diseases: from molecular mechanisms to targeted therapeutic potential., PMID:40456339
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice., PMID:40454481
PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung., PMID:40454475
Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma., PMID:40450984
Intestinal L-cell mechanoreception regulates hepatic lipid metabolism through GLP-1., PMID:40446026
PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence., PMID:40435254
Mechanosensitive Piezo1 channel is highly expressed in the age-induced fibrotic uterus., PMID:40434609
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance., PMID:40426179
The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets., PMID:40422197
The Mechanosensitive PIEZO1 Channel Contributes to the Reaction of RAW264.7 Macrophages to Mechanical Strain., PMID:40420945
Unveiling salivary gland-specific gene expression of Piezo1 and Neuroendocrine in the leech, Helobdella austinensis., PMID:40409700
Piezo1 Is an Early Mediator During Topography-Stimulated Osteogenic Differentiation of Bone Mesenchymal Stem Cells., PMID:40405805
PIEZO1 in the enteric nervous system keeps the gut going., PMID:40403702
Swimming induces bone loss via regulating mechanical sensing pathways in bone marrow., PMID:40395774
Bionic Triboelectric Nanogenerator Activates the "mechano-electro-biochemical" Cascade Effect In Situ to Accelerate Critical-Sized Bone Defect Repair., PMID:40394948
Piezo1 deficiency alleviates acute liver failure by inhibiting CpG-ODN induced inflammatory responses., PMID:40394794
Asperosaponin VI Promotes Osteoporotic Fracture Healing by Targeting Piezo1 to Enhance the Coupling of LEPR+ BMSCs and PODXL+ ECs., PMID:40393465
Yoda1-Loaded Microfibrous Scaffolds Accelerate Osteogenesis through Piezo1-F-Actin Pathway-Mediated YAP Nuclear Localization and Functionalization., PMID:40377908
Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review)., PMID:40376999
Implications of mechanosensitive ion channels in the pathogenesis of osteoarthritis: a comprehensive review., PMID:40376614
Piezo1/2 regulates gastric pepsinogen secretion of mandarin fish., PMID:40372577
Activation of Mechanosensitive Ion Channels Induces Autocrine and Paracrine Networks in Craniocervical Squamous Cell Carcinoma Cell via Endothelin Signaling., PMID:40368816
GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy., PMID:40361216
Mechanosensitive ion channel Piezo1 modulates the response of rat hippocampus neural stem cells to rapid stretch injury., PMID:40359437
Piezo Channels in Dentistry: Decoding the Functional Effects of Forces., PMID:40353513
Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway., PMID:40350445
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study., PMID:40341084
The key role of Piezo1 channels in ferroptosis after spinal cord injury and the therapeutic potential of Piezo1 inhibitors., PMID:40339662
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics., PMID:40327988
PIEZO1 Activation-Mediated Generation of Transgene-Free Long-Term Hematopoietic Stem Cells., PMID:40320799
A Chinese pediatric patient with thalassemia traits and compound heterozygous mutations in the PIEZO1 gene suspected of having dehydrated hereditary stomatocytosis., PMID:40320770
Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment., PMID:40310296
The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells., PMID:40304808
Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway., PMID:40286268
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases., PMID:40276938
Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia-reperfusion injury in mice., PMID:40263994
Tissue geometry spatiotemporally drives bacterial infections., PMID:40262607
[Research progress on the role of mechanically sensitive ion channel Piezo1 in vascular remodeling]., PMID:40255012
Piezo1-Mediated Calcium Flux Transfers Mechanosignal to Yes-Associated Protein to Stimulate Matrix Production in Keloid., PMID:40254148
The role of ion channels in the regulation of dendritic cell function., PMID:40253771
TRIM25 facilitates ferroptosis in ovarian cancer through promoting PIEZO1 K63-linked ubiquitination and degradation., PMID:40250035
Low-density electrospun fibrous network promotes mechanotransduction and matrix remodeling in fibroblasts., PMID:40245813
Piezo1 Is Related to the Enamel Matrix Formation in Mouse Tooth Germ Development., PMID:40237554
Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells., PMID:40232231
Piezo1 in microglial cells: Implications for neuroinflammation and tumorigenesis., PMID:40223276
Mechanical stress overload promotes NF-κB/NLRP3-mediated osteoarthritis synovitis and fibrosis through Piezo1., PMID:40221068
Mitigating effects of hydroxysafflor yellow a on atherosclerotic inflammatory responses based on flavonoid macromolecule compound: Inhibition of Piezo1-YAP/JNK protein pathway., PMID:40220830
For research use only. Not for human or drug use.
