Catalog No.
PHA75501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ACTN4 (Tyr611-Leu911).
Tested applications
ELISA: 1:2000-1:8000, IHC: 1:50-1:100, WB: 1:500-1:4000
Target
Non-muscle alpha-actinin 4,Alpha-actinin-4,ACTN4
Concentration
0.84 mg/ml
Purification
Purified by antigen affinity column.
Accession
O43707
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells., PMID:38822246
Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors., PMID:38299456
Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases., PMID:38106587
Saliva changes in composition associated to COVID-19: a preliminary study., PMID:35760827
Huangqi Guizhi Wuwu Decoction attenuates Podocyte cytoskeletal protein damage in IgA nephropathy rats by regulating AT1R/Nephrin/c-Abl pathway., PMID:34339916
Identification of a Novel ACTN4 Gene Mutation Which Is Resistant to Primary Nephrotic Syndrome Therapy., PMID:31930129
Isolation of human monoclonal antibodies that bind to two different antigens and are encoded by germline VH and VL genes., PMID:29944883
Four PTEN-targeting co-expressed miRNAs and ACTN4- targeting miR-548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue., PMID:28779483
Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing., PMID:27977723
Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival., PMID:27155012
Alpha-Actinin-4 is a Possible Target Protein for Aristolochic Acid I in Human Kidney Cells In Vitro., PMID:27080942
Focal segmental glomerulosclerosis: molecular genetics and targeted therapies., PMID:26156092
Increased expression of α-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer., PMID:23817592
Close relations between podocyte injuries and membranous proliferative glomerulonephritis in autoimmune murine models., PMID:23817053
Monoclonal antibody against α-actinin 4 from human umbilical vein endothelial cells inhibits endothelium-dependent vasorelaxation., PMID:23711888
Development of podocyte injuries in Osborne-Mendel rats is accompanied by reduced expression of podocyte proteins., PMID:23582971
The antigen-binding fragment of anti-double-stranded DNA IgG enhances F-actin formation in mesangial cells by binding to alpha-actinin-4., PMID:22929799
Diagnostic and prognostic significance of the alternatively spliced ACTN4 variant in high-grade neuroendocrine pulmonary tumours., PMID:22887464
Immunization with ovarian autoantigens leads to reduced fertility in mice following follicular dysfunction., PMID:22143970
Pdlim2 is a novel actin-regulating protein of podocyte foot processes., PMID:21814175
Mice with podocyte-specific overexpression of wild type alpha-actinin-4 are healthy controls for K256E-alpha-actinin-4 mutant transgenic mice., PMID:19585264
Patients with ACTN4 mutations demonstrate distinctive features of glomerular injury., PMID:19357256
RelA/NF-kappaB transcription factor associates with alpha-actinin-4., PMID:18215660
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins., PMID:16944923
Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin., PMID:16751418
Regulation of DNaseY activity by actinin-alpha4 during apoptosis., PMID:15002038
A novel protein, densin, expressed by glomerular podocytes., PMID:12819232
Broadening the spectrum of diseases related to podocin mutations., PMID:12707396
Renal alpha-actinin-4: purification and puromycin aminonucleoside-binding property., PMID:12411747
Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution., PMID:12093915
Interactions of a hemidesmosome component and actinin family members., PMID:11739652
Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging., PMID:10954430
Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis., PMID:10700177
Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion., PMID:9508771
For research use only. Not for human or drug use.
