Catalog No.
PAH02201
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
Pembrolizumab
Tested applications
ELISA: 1:4000-1:8000
Target
Rabbit polyclonal to Keytruda.
Specificity
The product is specific for Pembrolizumab. This antibody serves as an excellent positive control for Pembrolizumab immunogenicity (ADA) assays.
Concentration
1.68 mg/ml
Purification
Purified by antigen affinity column.
Accession
CAS: 1374853-91-4
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at - 80°C long term.
Background
Pembrolizumab (Keytruda) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma. Pembrolizumab binds to the human cell surface receptor PD-1 (Programmed Cell Death Protein 1) and blocks its interaction with PD-L1, resulting in the activation of T-cell-mediated immune responses against tumor cells. Antibodysystem Anti-Pembrolizumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Pembrolizumab.
A simple and low-cost paper chip-based smartphone sensor for enumeration of T lymphocyte subsets., PMID:40513165
Diagnosing past infections: A review., PMID:40513136
The clock component LHY1b negatively regulates alkaline stress by repressing AOX1-mediated oxidative responses in soybean., PMID:40513111
Clinical and Electrodiagnostic Findings in Anti-myelin-Associated Glycoprotein Antibody Polyneuropathy: A Single Center Review., PMID:40513035
Editorial: Endomysial Antibodies for a No-Biopsy Diagnosis of Coeliac Disease-The Jury Is Still Out., PMID:40512993
Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition., PMID:40512984
Editorial: Endomysial Antibodies for a No-Biopsy Diagnosis of Coeliac Disease-The Jury Is Still out. Authors' Reply., PMID:40512983
AbEpiTope-1.0: Improved antibody target prediction by use of AlphaFold and inverse folding., PMID:40512857
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance., PMID:40512837
Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer's disease., PMID:40512826
Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex., PMID:40512800
RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ., PMID:40512793
Cost-effectiveness analysis of adebrelimab in combination with chemotherapy for first-line treatment of extensive-stage small cell lung cancer., PMID:40512778
Prognostic impact of HER2-low expression in triple-negative breast cancer of high-grade special histological type and no special type., PMID:40512776
Computational Mapping of Conformational Dynamics and Interaction Hotspots of Human VISTA with pH-Selective Antibodies., PMID:40512745
The dichotomous impacts of Semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models., PMID:40512736
The Entry of Zika Virus into the Cells and Its Implication for Antiviral Therapy., PMID:40512550
IL-33 Has a Protective Effect Against Perinatal Listeriosis by Regulating Mitophagy of CD8+ T Lymphocytes., PMID:40512525
Stereotactic body radiation therapy (SBRT) increases anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma., PMID:40512454
Characteristics of Two Saccharomyces cerevisiae Strains and Their Extracellular Vesicles as New Candidates for Probiotics., PMID:40512446
TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation., PMID:40512402
CD11b as a diagnostic biomarker of rheumatoid arthritis and as a risk factor of periodontitis: a pilot study., PMID:40512337
Methods for Evaluation of Antivirals and Neutralizing Antibodies Against Tick-Borne Encephalitis Virus., PMID:40512316
Quantification of Neutralizing Antibodies of Tick-Borne Viruses Using Focus Neutralization Assays., PMID:40512315
Immunofluorescence Assays to Visualize Tick-Borne Flaviviruses in Mouse Skin or Brain., PMID:40512312
Immunohistochemical Assays to Visualize Tick-Borne Flaviviruses at the Tick Feeding Site., PMID:40512311
Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET., PMID:40512279
A novel killed oil adjuvanted bovine viral diarrhea virus vaccine protects from viremia and clinical manifestations: an immune response and challenge study in cattle., PMID:40512232
ctDNA Analysis in ERBB2-Amplified Colorectal Cancer: Biomarker Analysis of the MyPathway Trial., PMID:40512191
Longitudinal Imaging Reveals Tumor Uptake and Prolonged Retention of Bi-Specific T-Cell Engaging Antibody in GBM via Passive and Active Mechanisms., PMID:40512178
Immune-modulatory effects of Spindlin-1 inhibitors., PMID:40512144
Mechanistic investigation of calcium phosphate mineralization potentiating the cellular immune response of foot-and-mouth disease virus-like particle vaccines., PMID:40512119
The impact of anti-M antibodies on patient blood typing and transfusion safety: a retrospective study., PMID:40512094
Pharmacokinetics, Receptor Occupancy, and Pharmacodynamics of Obexelimab Following Intravenous Administration in Adult Healthy Volunteers and in Patients With Rheumatoid Arthritis., PMID:40512061
Monoclonal antibody neutralizes Staphylococcus aureus serine protease-like protein B (SplB)-induced pathology., PMID:40512005
Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex., PMID:40511941
Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopes., PMID:40511920
Mechanism of Bispecific Antibodies and Clinical Research Advances in Lung Cancer., PMID:40511831
LiGeR-HN phase III trials of petosemtamab + pembrolizumab and petosemtamab monotherapy in recurrent or metastatic HNSCC., PMID:40511820
Ultrafast point-of-care colorimetric detection of dengue using gold nanoparticles capped with β-cyclodextrin modified NS1 antibody., PMID:40511750
Germline-targeting Strategies to Induce bNAbs against HIV-1., PMID:40511646
Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females., PMID:40511603
Perspectives on T-cell engaging therapies in relapsed/refractory indolent non-Hodgkin lymphoma., PMID:40511598
Impact of PD‑L1 upregulation on immune checkpoint inhibitor efficacy in triple‑negative breast cancer using a 4T1 murine model., PMID:40511536
Quantification of Folded and Misfolded Proinsulin Forms Using Nonreducing SDS-PAGE and Proinsulin-Specific Immunoblotting., PMID:40511414
Children with hepatitis B virus infections, Democratic Republic of the Congo., PMID:40511401
Role of Ocrelizumab in modulating gene and microRNA expression in multiple sclerosis., PMID:40510879
Comprehensive analysis of SARS-CoV-2 Spike evolution: epitope classification and immune escape prediction., PMID:40510757
A Case of Acute Kidney Injury During Eltrombopag Use Successfully Treated With Plasma Exchange in Addition to Antithrombotic Therapy., PMID:40510611
Conformational Landscaping and Dynamic Mutational Profiling of Binding Interactions and Immune Escape for Broadly Neutralizing Class I Antibodies with SARS-CoV-2 Spike Protein: Distributed Binding Hotspot Networks Underlie Mechanism of Viral Resistance Against Existing Variants., PMID:40510568
For research use only. Not for human or drug use.
