Catalog No.
DHC20802
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
Erythrocyte receptor, SRBC, T-cell surface antigen CD2, Rosette receptor, CD2, LFA-3 receptor, T-cell surface antigen T11/Leu-5, LFA-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P06729
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
BTI-322, BTI 322, BTI322
Clone ID
BTI-322
Pharmacokinetic and pharmacodynamic study of a clinically effective anti-CD2 monoclonal antibody., PMID:31630416
Monoclonal antibody-induced cytokine-release syndrome., PMID:20477639
The anti-CD2 monoclonal antibody BTI-322 generates unresponsiveness by activation-associated T cell depletion., PMID:15544625
A role for CD2 antibodies (BTI-322 and its humanized form) in the in vivo elimination of human T lymphocytes infiltrating an allogeneic human skin graft in SCID mice: an Fcgamma receptor-related mechanism involving co-injected human NK cells., PMID:15257038
Targeting additional costimulatory pathways: a subtle role for CD2., PMID:11266778
Inhibition of human anti-pig T cell response by anti-CD2, anti-CD40L, and CTLA4-Ig: a comparative study., PMID:10936275
The experimental (in vitro) and clinical (in vivo) immunosuppressive effects of a rat IgG2b anti-human CD2 mAb, LO-CD2a/BTI-322., PMID:10798765
BTI 322. Anti-CD2 monoclonal antibody, Lo-CD2-a, monoclonal antibody Lo-CD2-a., PMID:10565990
Apoptosis of human naive NK cells mediated by a rat IgG2b anti CD2 mAb through a fractricidal ADCC reaction., PMID:10424425
A phase II study of BTI-322, a monoclonal anti-CD2 antibody, for treatment of steroid-resistant acute graft-versus-host disease., PMID:9834211
Potent apoptotic signaling and subsequent unresponsiveness induced by a single CD2 mAb (BTI-322) in activated human peripheral T cells., PMID:9558083
Prevention of rejection with BTI-322 after renal transplantation (results at 9 months)., PMID:9270793
BTI-322 for acute rejection after renal transplantation., PMID:9270759
BTI-322 for induction therapy after renal transplantation: a randomized study., PMID:9123018
An anti-CD2 mAb induces immunosuppression and hyporesponsiveness of CD2+ human T cells in vitro., PMID:8757956
A rat monoclonal anti-(human CD2) and L-leucine methyl ester impacts on human/SCID mouse graft and B lymphoproliferative syndrome., PMID:7627995
For research use only. Not for human or drug use.
