Catalog No.
DHJ04401
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
B7H6, NCR3LG1, B7-H6, Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q68D85
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CYAD-05, CYAD 05, CYAD05
Clone ID
CYAD-05
Analysis of a new therapeutic target and construction of a prognostic model for breast cancer based on ferroptosis genes., PMID:37643511
NKp30 Receptor Upregulation in Salivary Glands of Sjögren's Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment., PMID:34594326
Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30., PMID:34046711
Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer., PMID:33824367
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy., PMID:33483421
Affinity Maturation of B7-H6 Translates into Enhanced NK Cell-Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement., PMID:33268483
B7-H6 as an efficient target for T cell-induced cytotoxicity in haematologic malignant cells., PMID:32770284
Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ., PMID:31921143
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies., PMID:29476010
Chimeric antigen receptors with human scFvs preferentially induce T cell anti-tumor activity against tumors with high B7H6 expression., PMID:29453518
Development of unique cytotoxic chimeric antigen receptors based on human scFv targeting B7H6., PMID:29040754
Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30., PMID:27663271
B7H6-derived peptides trigger TNF-α-dependent immunostimulatory activity of lymphocytic NK92-MI cells., PMID:27216712
Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production., PMID:26582946
NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure., PMID:26241657
Expression, crystallization and X-ray diffraction analysis of a complex between B7-H6, a tumor cell ligand for the natural cytotoxicity receptor NKp30, and an inhibitory antibody., PMID:26057798
B7H6-Specific Bispecific T Cell Engagers Lead to Tumor Elimination and Host Antitumor Immunity., PMID:25911747
Allogeneic and xenogeneic anti-tumor effect of callithrix jacchus natural killer cells is dependent on NKp30 and B7-H6 interaction., PMID:25001651
Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells., PMID:23801635
Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions., PMID:23687088
Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity., PMID:23066150
Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC., PMID:22488247
Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6., PMID:21422170
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans., PMID:19528259
For research use only. Not for human or drug use.
