Catalog No.
DHA42307
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG2-kappa
Clonality
Monoclonal
Target
ANG-2, ANGPT2, Angiopoietin-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O15123
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MEDI-3617, MEDI 3617, MEDI3617
Clone ID
MEDI-3617
Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial., PMID:34772758
Angiopoietin inhibitors: A review on targeting tumor angiogenesis., PMID:33741382
Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development., PMID:30806847
Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors., PMID:29559563
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages., PMID:27044097
Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression., PMID:23412563
Inhibition of endothelial/smooth muscle cell contact loss by the investigational angiopoietin-2 antibody MEDI3617., PMID:22387475
MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models., PMID:22327175
For research use only. Not for human or drug use.
