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Anti-ALPL Polyclonal Antibody

Catalog #:   PHC15301 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P05186
Overview

Catalog No.

PHC15301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ALPL (Leu18-Ser501).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Alkaline phosphatase liver/bone/kidney isozyme, AP-TNAP, TNSALP, Alkaline phosphatase, tissue-nonspecific isozyme, ALPL

Purification

Purified by antigen affinity column.

Accession

P05186

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with ALPL antibody (PHC15301) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 56 kDa
    Observed MW: 56 kDa
References

Ectonucleotidases and purinergic receptors in mouse prostate gland., PMID:40400995

Effects of asfotase alfa on fracture healing of adult patient with hypophosphatasia and literature review., PMID:40189581

Safety and efficacy of long term asfotase alfa treatment in childhood hypophosphatasia., PMID:40114282

Diagnosis and Treatment of Hypophosphatasia., PMID:40047955

Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions: a case report with review of literature., PMID:39880615

Preclinical evaluation of the efficacy and safety of adeno-associated virus 8-tissue-nonspecific alkaline phosphatase-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia., PMID:39799564

Adult-onset hypophosphatasia diagnosed after consecutive tooth loss during orthodontic treatment: a case report., PMID:39702252

Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168

Effectiveness of asfotase alfa for treatment of adults with hypophosphatasia: results from a global registry., PMID:38459585

Isolation and In Vitro Culture of Germ Cells and Sertoli Cells from Human Fetal Testis., PMID:38351447

Impressive clinical improvement and disappearance of neuropathic pain in an adult patient with hypophosphatasia treated with asfotase alfa., PMID:38325645

Hypophosphatasia: presentation and response to asfotase alfa., PMID:37993691

ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma., PMID:37291203

Increased carotid intima-media thickening and antioxidized low-density lipoprotein in an anti-Ro60 SLE autoantibody subset., PMID:39055110

The molecular mechanism research of cartilage calcification induced by osteoarthritis., PMID:35611765

Status Epilepticus due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia., PMID:35303588

A Japanese single-center experience of the efficacy and safety of asfotase alfa in pediatric-onset hypophosphatasia., PMID:35197081

Bevacizumab and sunitinib mediate osteogenic and pro-inflammatory molecular changes in primary human alveolar osteoblasts in vitro., PMID:35171372

Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development., PMID:35098920

Dental outcomes for children receiving asfotase alfa for hypophosphatasia., PMID:34175501

Hypophosphatasia., PMID:33931563

Investigation of ALPL variant states and clinical outcomes: An analysis of adults and adolescents with hypophosphatasia treated with asfotase alfa., PMID:33814268

Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion., PMID:33335129

Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia., PMID:33301963

Predictive Power of Bone Turnover Biomarkers to Estimate Bone Mineral Density after Kidney Transplantation with or without Denosumab: A post hoc Analysis of the POSTOP Study., PMID:32998144

Adult hypophosphatasia manifests in a marathon runner., PMID:32912883

Physiological blood-brain transport is impaired with age by a shift in transcytosis., PMID:32612231

Influence of inflammatory conditions provided by macrophages on osteogenic ability of mesenchymal stem cells., PMID:32054534

Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase., PMID:32028019

Effect of Asfotase Alfa on Muscle Weakness in a Japanese Adult Patient of Hypophosphatasia with Low ALP Levels., PMID:31787692

Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration., PMID:31425530

Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy., PMID:31000369

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

Hypophosphatasia: Canadian update on diagnosis and management., PMID:30915507

No vascular calcification on cardiac computed tomography spanning asfotase alfa treatment for an elderly woman with hypophosphatasia., PMID:30825650

Considerations for high-yield, high-throughput cell enrichment: fluorescence versus magnetic sorting., PMID:30659223

Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates., PMID:30655187

Improvement of bone microarchitecture parameters after 12 months of treatment with asfotase alfa in adult patient with hypophosphatasia: Case report., PMID:30508901

Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy., PMID:30288020

Enzyme-replacement therapy in perinatal hypophosphatasia: Case report and review of the literature., PMID:30249491

Hypophosphatasia: From Diagnosis to Treatment., PMID:30203264

Spurious testosterone laboratory results in a patient taking synthetic alkaline phosphatase (asfotase alfa)., PMID:29709501

Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis., PMID:29528446

Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa., PMID:28888853

Glucomannan consumption elevates colonic alkaline phosphatase activity by up-regulating the expression of IAP-I, which is associated with increased production of protective factors for gut epithelial homeostasis in high-fat diet-fed rats., PMID:28739053

Transgelin mediates transforming growth factor-β1-induced proliferation of human periodontal ligament cells., PMID:28590058

Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia., PMID:28436937

Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial., PMID:28374482

The Pluripotent Stem-Cell Marker Alkaline Phosphatase is Highly Expressed in Refractory Glioblastoma with DNA Hypomethylation., PMID:28173571

Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis., PMID:28106886

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-ALPL Polyclonal Antibody [PHC15301]
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