Anti-HDAC3 Polyclonal Antibody

Catalog No.

PHA50901

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HDAC3 (Met1-Gln376).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HD3,SMAP45,RPD3-2,Histone deacetylase 3,HDAC3

Purification

Purified by antigen affinity column.

Accession

O15379

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475

Acetylation profiling by Iseq-Kac reveals insights into HSC aging and lineage decision., PMID:40419771

Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis., PMID:39922804

Proteomic identification of a Toxoplasma gondii sporozoite-specific antigen using HDAC3 inhibitor-treated tachyzoites as surrogate., PMID:39802703

The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression., PMID:38718296

PD-L1 Expression in Neoplastic and Immune Cells of Thymic Epithelial Tumors: Correlations with Disease Characteristics and HDAC Expression., PMID:38672128

Molecular characterization of the B lymphocyte-induced maturation protein-1 (blimp1) gene of common carp (Cyprinus carpio) and its transcription repression involves recruitment of histone deacetylase HDAC3., PMID:37944681

Vitamin D3 mitigates autoimmune inflammation caused by activation of myeloid dendritic cells in SLE., PMID:37702410

Antibodies of the immunoglobulin a isotype to novel antigens in early axial spondyloarthritis., PMID:36844956

Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells., PMID:35333906

Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells., PMID:33809839

RGFP966, a selective HDAC3 inhibitor, ameliorates allergic and inflammatory responses in an OVA-induced allergic rhinitis mouse model., PMID:33529911

Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer., PMID:32934224

(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo., PMID:31985048

FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions., PMID:31597362

EGFR-c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells., PMID:31430896

Improved early development of porcine cloned embryos by treatment with quisinostat, a potent histone deacetylase inhibitor., PMID:30587665

Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling., PMID:30066852

MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3., PMID:29774080

PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation., PMID:29555935

Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration., PMID:29486577

HDAC inhibitors enhance the immunotherapy response of melanoma cells., PMID:29137331

Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development., PMID:28739911

IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors., PMID:28525378

Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes., PMID:27507813

Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines., PMID:27250763

Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3., PMID:26786103

HDAC3 mediates smoking-induced pancreatic cancer., PMID:26745602

JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus., PMID:26347123

Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor., PMID:26305553

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer., PMID:25980579

MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells., PMID:25907560

GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling., PMID:25726523

Interferon regulatory factor 1 and histone H4 acetylation in systemic lupus erythematosus., PMID:25611806

Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury., PMID:25261965

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis., PMID:25185156

Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3., PMID:24922625

Analysis of candidate genes for lineage-specific expression changes in humans and primates., PMID:24911366

Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats., PMID:24636283

The Notch co-repressor protein NKAP is highly expressed in adult mouse subventricular zone neural progenitor cells., PMID:24583034

Combination of S-adenosylhomocysteine and scriptaid, a non-toxic epigenetic modifying reagent, modulates the reprogramming of bovine somatic-cell nuclear transfer embryos., PMID:24347442

The corepressor Atrophin specifies odorant receptor expression in Drosophila., PMID:24334704

Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2., PMID:24045946

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells., PMID:23801635

Histone deacetylase inhibition attenuates transcriptional activity of mineralocorticoid receptor through its acetylation and prevents development of hypertension., PMID:23421989

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner., PMID:23297220

Identifying acetylated proteins in mitosis., PMID:22903717

Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells., PMID:22751009

DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina., PMID:22726435

Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3., PMID:22338096

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