Research Grade Anti-Human CD112R/PVRIG (GSK4381562)

Catalog No.

DHK16201

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

C7orf15, CD112R, CD112 receptor receptor-related immunoglobulin domain-containing protein, PVRIG, Transmembrane protein PVRIG

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6DKI7

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

anti-PVRIG, GSK-4381562, GSK'562, SRF 813

Clone ID

GSK4381562

Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT., PMID:37675979

Emergence of the CD226 Axis in Cancer Immunotherapy., PMID:35812451

Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer., PMID:34503073

Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors., PMID:34174928

Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy., PMID:33298247

Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions., PMID:28623459

Document Download

Research Grade Anti-Human CD112R/PVRIG (GSK4381562).pdf