Catalog No.
DHJ21601
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-lambda
Clonality
Monoclonal
Target
CD85 antigen-like family member D, Monocyte/macrophage immunoglobulin-like receptor 10, MIR-10, ILT4, LIR-2, ILT-4, Immunoglobulin-like transcript 4, MIR10, CD85d, Leukocyte immunoglobulin-like receptor subfamily B member 2, Leukocyte immunoglobulin-like receptor 2, LIR2, LILRB2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8N423
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
1E1#
Case report: Lichenoid eruption under immunotherapy with MK-4830 and pembrolizumab in a breast cancer patient., PMID:39193329
Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism., PMID:38162675
KEYSTEP-008: phase II trial of pembrolizumab-based combination in MSI-H/dMMR metastatic colorectal cancer., PMID:37701986
Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors., PMID:36780212
Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells., PMID:35536993
Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells., PMID:37017286
Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 Infection., PMID:34938296
HLA-G gene editing in tumor cell lines as a novel alternative in cancer immunotherapy., PMID:34773056
First-in-Class Anti-immunoglobulin-like Transcript 4 Myeloid-Specific Antibody MK-4830 Abrogates a PD-1 Resistance Mechanism in Patients with Advanced Solid Tumors., PMID:34598945
HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges., PMID:34276691
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation., PMID:33537094
ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells., PMID:33372059
The expression and function of immunoglobulin-like transcript 4 in dendritic cells from patients with hepatocellular carcinoma., PMID:33228921
The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?, PMID:33213057
The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma., PMID:32620162
Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection., PMID:31824485
Neuropilin-1 Acts as a Receptor for Complement Split Products., PMID:31572401
Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural Tuberculosis., PMID:29559123
Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine., PMID:29244203
Identification of unique proteomic signatures in allergic and non-allergic skin disease., PMID:28703865
Multiplex bead-based immunoassay for the free soluble forms of the HLA-G receptors, ILT2 and ILT4., PMID:26874236
Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d., PMID:26678451
Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6., PMID:26119336
Downregulation of immunoglobulin-like transcript-4 (ILT4) in patients with psoriatic arthritis., PMID:24676037
Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3., PMID:23018130
Analysis of immunoglobulin-like transcripts (ILTs) in lymphocytes with sHLA-G and IL10 from SLE patients., PMID:22562117
Human myeloid dendritic cells are refractory to tryptophan metabolites., PMID:21699942
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells., PMID:21300911
Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells., PMID:20957751
Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells., PMID:19405174
Changes in the expression of the immunoglobulin-like transcript 3 (ILT3) and ILT4 receptors in renal allograft recipients: effect of donor and recipient aging., PMID:19010139
IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells., PMID:17163451
Report of the Wet Workshop for Quantification of Soluble HLA-G in Essen, 2004., PMID:16216668
Cell-surface expression and immune receptor recognition of HLA-B27 homodimers., PMID:12428240
Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors., PMID:11169396
Tubal versus uterine placentation: similar HLA-G expressing extravillous cytotrophoblast invasion but different maternal leukocyte recruitment., PMID:11169237
Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells., PMID:10190906
For research use only. Not for human or drug use.
