Catalog No.
PHA17401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CCL22/MDC (Gly25-Gln93).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
MDC(1-69),SCYA22,Macrophage-derived chemokine,CCL22,Stimulated T-cell chemotactic protein 1,CC chemokine STCP-1,Small-inducible cytokine A22,C-C motif chemokine 22,MDC
Purification
Purified by antigen affinity column.
Accession
O00626
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor., PMID:39829150
Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor., PMID:39482116
CCL17, CCL22 and their receptor CCR4 in hematologic malignancies., PMID:39240278
Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma., PMID:39097197
Macrophage activation and inflammatory priming by anti-MAA antibodies in rheumatoid arthritis., PMID:38969267
Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure., PMID:38924414
Insights into Therapeutic Response Prediction for Ustekinumab in Ulcerative Colitis Using an Ensemble Bioinformatics Approach., PMID:38791570
Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance., PMID:38691100
Development of a novel humanized anti-TSLP monoclonal antibody HZ-1127 with anti-allergic diseases and cancer potential., PMID:38566968
Status of B-Lymphocyte Subsets and Their Homing Markers in Patients With Post-Kala-Azar Dermal Leishmaniasis., PMID:38527908
Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial., PMID:38483248
Proteomic, miRNA and bacterial biomarker patterns in atopic dermatitis patients and their course upon anti-IL-4Rα therapy., PMID:38379385
Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia., PMID:38360867
The Potential Role of Moringa oleifera Lam. Leaf Proteins in Moringa Allergy by Functionally Activating Murine Bone Marrow-Derived Dendritic Cells and Inducing Their Differentiation toward a Th2-Polarizing Phenotype., PMID:38201837
High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy., PMID:38016720
Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment., PMID:37742620
Atlas of the anatomical localization of atypical chemokine receptors in healthy mice., PMID:37159457
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction., PMID:37124725
New Molecular and Biological Markers in Cutaneous T Cell Lymphoma: Therapeutic Implications., PMID:37017872
Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL-31 inhibition with lokivetmab., PMID:37006124
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma., PMID:36969873
Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment., PMID:36923280
A phase 1b single-arm trial of intratumoral oncolytic virus V937 in combination with pembrolizumab in patients with advanced melanoma: results from the CAPRA study., PMID:36445410
Relationship between cerebrospinal fluid biomarkers of inflammation and tissue damage in primary progressive multiple sclerosis., PMID:36257152
Identification of Novel Therapeutic Candidates Against SARS-CoV-2 Infections: An Application of RNA Sequencing Toward mRNA Based Nanotherapeutics., PMID:35983322
Identification of the Binding Epitope of an Anti-mouse CCR4 Monoclonal Antibody, C4Mab-1., PMID:35917564
Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers., PMID:35794623
Development of a Novel Anti-Mouse CCR4 Monoclonal Antibody (C4Mab-1) by N-Terminal Peptide Immunization., PMID:35471046
Conserved metabolic enzymes as vaccine antigens for giardiasis., PMID:35468132
CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma., PMID:35404390
Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response., PMID:35252461
Pharmacokinetics, Safety, Efficacy, and Biomarker Profiles During Nemolizumab Treatment of Atopic Dermatitis in Adolescents., PMID:35088348
Tuo-Min-Ding-Chuan Decoction Alleviate Ovalbumin-Induced Allergic Asthma by Inhibiting Mast Cell Degranulation and Down-Regulating the Differential Expression Proteins., PMID:34630102
Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals., PMID:34368878
Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer., PMID:34112709
Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development., PMID:34101271
Safety and efficacy profile of mogamulizumab (Poteligeo) in the treatment of cancers: an update evidence from 14 studies., PMID:34039310
Lipopolysaccharide from biofilm-forming Pseudomonas aeruginosa PAO1 induces macrophage hyperinflammatory responses., PMID:33909550
CCR4 in cutaneous T-cell lymphoma: Therapeutic targeting of a pathogenic driver., PMID:33811642
Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma., PMID:33784348
Affinity-coupled CCL22 promotes positive selection in germinal centres., PMID:33597749
Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab., PMID:33521616
Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council., PMID:33516871
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade., PMID:33483337
STAT3/NF-κB signalling disruption in M2 tumour-associated macrophages is a major target of PLGA nanocarriers/PD-L1 antibody immunomodulatory therapy in breast cancer., PMID:33434950
Cytokines/Chemokines: Potential Biomarkers for Non-paraneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis., PMID:33408682
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4., PMID:33243932
Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4+ Treg axis during remission of crescentic glomerulonephritis., PMID:33163184
Targeting Chemokines and Chemokine Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis., PMID:33061527
Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota., PMID:33016202
For research use only. Not for human or drug use.
