Catalog No.
PHA05601
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human LGALS8 (Met2-Trp317).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PCTA-1,Po66 carbohydrate-binding protein,Po66-CBP,Galectin-8,Gal-8,LGALS8,Prostate carcinoma tumor antigen 1
Purification
Purified by antigen affinity column.
Accession
O00214
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Luminex-based pilot study identifies novel serum autoantibodies associated with disease activity in patients with lupus nephritis., PMID:40500568
Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer., PMID:39000016
A Neoglycoprotein-Immobilized Fluorescent Magnetic Bead Suspension Multiplex Array for Galectin-Binding Studies., PMID:34684775
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies., PMID:31119556
Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly., PMID:30624618
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis., PMID:28650992
Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid., PMID:28192531
Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome., PMID:25649018
Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer., PMID:24886063
Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients., PMID:24346075
Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling., PMID:22973445
Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population., PMID:22683700
Galectin-1 is part of human trophoblast invasion machinery--a functional study in vitro., PMID:22174828
Galectin-8 in IgA nephritis: decreased binding of IgA by galectin-8 affinity chromatography and associated increased binding in non-IgA serum glycoproteins., PMID:22173878
Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy., PMID:20499060
Innate immune lectins kill bacteria expressing blood group antigen., PMID:20154696
Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation., PMID:19395456
Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation., PMID:19276072
Induction of cell adhesion by galectin-8 and its target molecules in Jurkat T-cells., PMID:18024965
[Antibodies against galectin-8 in patients with systemic lupus erythematosus]., PMID:16554922
Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells., PMID:16368432
Toward functional glycomics by localization of tissue lectins: immunohistochemical galectin fingerprinting during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster., PMID:15609042
Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor., PMID:11839721
Immunohistochemical expression of the intracellular component of galectin-8 in squamous cell metaplasia of the bronchial epithelium in neoplastic and benign processes., PMID:11795826
Expression of Po66-CBP, a galectin-8, in different types of primary and secondary broncho-pulmonary tumors., PMID:11748478
Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line., PMID:11675018
Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous system., PMID:11510978
The levels of expression of galectin-3, but not of galectin-1 and galectin-8, correlate with apoptosis in human cholesteatomas., PMID:11404618
Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues., PMID:10697573
Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family., PMID:8692978
Galectin-8. A new rat lectin, related to galectin-4., PMID:7852431
For research use only. Not for human or drug use.
