Catalog No.
FHA13510
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
BTF5, BTN3A1, Butyrophilin subfamily 3 member A1, CD277
Concentration
1.23 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O00481
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
hu103.2
Clone ID
103.2#
Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation. [FHA13510]
CD277 agonist enhances the immunogenicity of relapsed/refractory acute myeloid leukemia towards Vδ2+ T cell cytotoxicity., PMID:35920929
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells., PMID:32820120
γ9δ2T cell diversity and the receptor interface with tumor cells., PMID:32484803
Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset., PMID:32139608
Immunologic Consequences of Sequencing Cancer Radiotherapy and Surgery., PMID:30964698
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters., PMID:29670629
The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region., PMID:28705810
BTN3A1-antibodies and phosphoantigens: TCRVγ9Vδ2 "see" the difference., PMID:28597565
Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation., PMID:28386905
BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia., PMID:27853633
Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations., PMID:27619996
Phosphoantigens and butyrophilin 3A1 induce similar intracellular activation signaling in human TCRVγ9+ γδ T lymphocytes., PMID:24925024
Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells., PMID:23833237
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies., PMID:22846996
Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset., PMID:22767497
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells., PMID:21918970
For research use only. Not for human or drug use.
