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Anti-Human ROR2/NTRKR2 Antibody (GK-5A1)

Catalog #:   FHF90810 Specific References (48) DATASHEET
Host species: Mouse
Isotype: IgG1, kappa
Applications: ELISA, FCM
Accession: Q01974
Overview

Catalog No.

FHF90810

Species reactivity

Human, Monkey, Mouse

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

ROR2, Neurotrophic tyrosine kinase, receptor-related 2, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q01974

Applications

ELISA, FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

GK-5A1

Data Image
  • Bioactivity
    Detects ROR2/NTRKR2 in indirect ELISAs.
References

Preclinical development of ozuriftamab vedotin (BA3021), a novel ROR2-specific conditionally active biologic antibody-drug conjugate., PMID:40202784

Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma., PMID:39829682

Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy., PMID:38973261

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling., PMID:38780011

Detection of receptor tyrosine kinase-orphan receptor-2 using an electrochemical immunosensor modified with electrospun nanofibers comprising polyvinylpyrrolidone, soy, and gold nanoparticles., PMID:37770707

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma., PMID:36539575

Urine proteomic insights from the belimumab in lupus nephritis trial., PMID:36167482

Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)., PMID:35506763

ROR1 and ROR2 expression in pancreatic cancer., PMID:34763666

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications., PMID:32193207

Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1., PMID:32012403

Wnt5a/ROR1 activates DAAM1 and promotes the migration in osteosarcoma cells., PMID:31894282

ROR1 and ROR2-novel targets for neuroblastoma., PMID:31441359

Solution structure, dynamics and function investigation of Kringle domain of human receptor tyrosine kinase-like orphan receptor 1., PMID:31232192

ROR2 modulates neuropathic pain via phosphorylation of NMDA receptor subunit GluN2B in rats., PMID:30916039

Purification and characterization of the extracellular region of human receptor tyrosine kinase like orphan receptor 2 (ROR2)., PMID:30826310

Novel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells., PMID:30450096

Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling., PMID:29151594

A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management., PMID:29058491

Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility., PMID:28818634

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle., PMID:28790171

Molecular genetics and targeted therapy of WNT-related human diseases (Review)., PMID:28731148

Wnt5A regulates the expression of ROR2 tyrosine kinase receptor in ovarian cancer cells., PMID:28538104

WNT5A-ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3., PMID:28536612

Targeting ROR1 identifies new treatment strategies in hematological cancers., PMID:28408486

Receptor for advanced glycation end product blockade enhances the chemotherapeutic effect of cisplatin in tongue squamous cell carcinoma by reducing autophagy and modulating the Wnt pathway., PMID:27831944

Validation of specificity of antibodies for immunohistochemistry: the case of ROR2., PMID:27631337

Erratum to: Validation of specificity of antibodies for immunohistochemistry: the case of ROR2., PMID:27796585

CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling., PMID:27191743

CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells., PMID:26771355

Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling., PMID:26730270

Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis., PMID:26708384

Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells Through TGFβ1-Mediated Upregulation of Periostin Expression., PMID:25655430

Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine., PMID:25211363

Layer-specific gene expression in epileptogenic type II focal cortical dysplasia: normal-looking neurons reveal the presence of a hidden laminar organization., PMID:24735483

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling., PMID:23602936

ROR2 and Wnt5a expression in stage 1 pure testicular seminomas., PMID:23469623

ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy., PMID:22655270

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells., PMID:22634564

Wnt signaling in the pathogenesis of multiple sclerosis-associated chronic pain., PMID:22547300

Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis., PMID:22493546

Structures of Abeta-related peptide--monoclonal antibody complexes., PMID:19385664

Ror2, a novel modulator of osteogenesis., PMID:18094493

Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation., PMID:17717073

WNT signaling pathway and stem cell signaling network., PMID:17634527

Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells., PMID:17463182

STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review)., PMID:17203201

WNT/PCP signaling pathway and human cancer (review)., PMID:16273260

Datasheet
$ 225
Product specifications
50 μg 225 100 μg 372

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Anti-Human ROR2/NTRKR2 Antibody (GK-5A1) [FHF90810]
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