Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors. PMID: 35921789
4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators. PMID: 34979256
Diazepinone HBV capsid assembly modulators. PMID: 35644301
Major findings and recent advances in virus-like particle (VLP)-based vaccines. PMID: 28887001
Endoplasmic reticulum stress promotes HBV production by enhancing use of the autophagosome/multivesicular body axis. PMID: 34580902
Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly. PMID: 24462683
Oxadiazepinone HBV capsid assembly modulators. PMID: 34492302
An in silico study to unveil potential drugs and vaccine chimera for HBV capsid assembly protein: combined molecular docking and dynamics simulation approach. PMID: 35112241
Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation. PMID: 36226986
Capsid Assembly Modulators as Antiviral Agents against HBV: Molecular Mechanisms and Clinical Perspectives. PMID: 35268440
Core protein: A pleiotropic keystone in the HBV lifecycle. PMID: 26129969
Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778. PMID: 36144715
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B. PMID: 32818519
HBV Core Protein Is in Flux between Cytoplasmic, Nuclear, and Nucleolar Compartments. PMID: 33563815
Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers. PMID: 21126747
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors. PMID: 32712535
Di-Fluoro Azepane HBV Capsid Assembly Modulators. PMID: 37247697
Reactive oxygen species promote heat shock protein 90-mediated HBV capsid assembly. PMID: 25576869
Biogenesis and molecular characteristics of serum hepatitis B virus RNA. PMID: 33079954
Identification of a new class of HBV capsid assembly modulator. PMID: 33610748
Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein. PMID: 37243280
Recent advances in the development of HBV capsid assembly modulators. PMID: 30952041
Pyrimidotriazine derivatives as selective inhibitors of HBV capsid assembly. PMID: 31376401
Dynamics of Hepatitis B Virus Capsid Protein Dimer Regulate Assembly through an Allosteric Network. PMID: 32662972
Role of core protein mutations in the development of occult HBV infection. PMID: 33453326
Heat shock protein 70 and heat shock protein 90 synergistically increase hepatitis B viral capsid assembly. PMID: 30115382
The Origin of Capsid-Derived Immune Complexes and Their Impact on HBV-Induced Liver Diseases. PMID: 36560770
Generation of an HBV core phenotyping assay for evaluating HBV capsid compounds. PMID: 33657432
Modulators of HBV capsid assembly as an approach to treating hepatitis B virus infection. PMID: 27636324
RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation. PMID: 34287051
Towards HBV curative therapies. PMID: 29427479
Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro. PMID: 32417895
Carboxy-terminal truncations of the HBV core protein affect capsid formation and the apparent size of encapsidated HBV RNA. PMID: 7684872
Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket. PMID: 36042894
Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays. PMID: 33721800
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein. PMID: 34826506
Hepatitis B Virus Core Protein Domains Essential for Viral Capsid Assembly in a Cellular Context. PMID: 32371046
The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals. PMID: 29183719
Viral structural proteins as targets for antivirals. PMID: 32777753
VHL-independent degradation of hepatitis B virus e antigen (HBeAg) by VHL-binding chimeric small molecules., PMID:40276592
Induction of hepatitis B core protein aggregation targeting an unconventional binding site., PMID:40135596
Computer-aided drug repurposing & discovery for Hepatitis B capsid protein., PMID:40018383
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein., PMID:38780261
TRPV4 promotes HBV replication and capsid assembly via methylation modification of H3K4 and HBc ubiquitin., PMID:38573018
Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation., PMID:38315015
Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis., PMID:38129531
A novel phthalazinone derivative as a capsid assembly modulator inhibits hepatitis B virus expression., PMID:38008192
What will it take to cure hepatitis B?, PMID:36972391
Hierarchical Coarse-Grained Strategy for Macromolecular Self-Assembly: Application to Hepatitis B Virus-Like Particles., PMID:36499027
Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation., PMID:35867543
Binding of a Pocket Factor to Hepatitis B Virus Capsids Changes the Rotamer Conformation of Phenylalanine 97., PMID:34834922
The Hepatitis B Virus Nucleocapsid-Dynamic Compartment for Infectious Virus Production and New Antiviral Target., PMID:34829806
Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids., PMID:34705562
Structural and Functional Characterizations of Cancer Targeting Nanoparticles Based on Hepatitis B Virus Capsid., PMID:34502049
Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication., PMID:33493210
Efficient Production of Chimeric Hepatitis B Virus-Like Particles Bearing an Epitope of Hepatitis E Virus Capsid by Transient Expression in Nicotiana benthamiana., PMID:33477348
Role of core protein mutations in the development of occult HBV infection., PMID:33453326
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., PMID:33441627
Virion Secretion of Hepatitis B Virus Naturally Occurring Core Antigen Variants., PMID:33396864
D e novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA., PMID:33385130
S6K1 inhibits HBV replication through inhibiting AMPK-ULK1 pathway and disrupting acetylation modification of H3K27., PMID:33278383
Covalent protein display on Hepatitis B core-like particles in plants through the in vivo use of the SpyTag/SpyCatcher system., PMID:33051543
Intracellular Trafficking of HBV Particles., PMID:32887393
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B., PMID:32818519
Phosphorylation of the Arginine-Rich C-Terminal Domains of the Hepatitis B Virus (HBV) Core Protein as a Fine Regulator of the Interaction between HBc and Nucleic Acid., PMID:32650547
Virus-like particle vaccine with B-cell epitope from porcine epidemic diarrhea virus (PEDV) incorporated into hepatitis B virus core capsid provides clinical alleviation against PEDV in neonatal piglets through lactogenic immunity., PMID:32565343
Peculiarities in the designations of hepatitis B virus genes, their products, and their antigenic specificities: a potential source of misunderstandings., PMID:32026198
BAY 41-4109-mediated aggregation of assembled and misassembled HBV capsids in cells revealed by electron microscopy., PMID:31302151
Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus., PMID:30936483
Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives., PMID:30896149
Assembly and Characterization of HBc Derived Virus-like Particles with Magnetic Core., PMID:30691173
Cetylpyridinium chloride interaction with the hepatitis B virus core protein inhibits capsid assembly., PMID:30639191
ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection., PMID:30403127
Hepatitis B virus core protein dimer‑dimer interface is critical for viral replication., PMID:30387827
CpAMs induce assembly of HBV capsids with altered electrophoresis mobility: Implications for mechanism of inhibiting pgRNA packaging., PMID:30201396
Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition., PMID:30100358
Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals., PMID:30089690
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro., PMID:30031759
High-level expression and enrichment of norovirus virus-like particles in plants using modified geminiviral vectors., PMID:29908914
Displaying Whole-Chain Proteins on Hepatitis B Virus Capsid-Like Particles., PMID:29869263
Multiple roles of core protein linker in hepatitis B virus replication., PMID:29782550
Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide., PMID:29653575
Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids., PMID:29377794
The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals., PMID:29183719
Hepatitis B core protein promotes liver cancer metastasis through miR-382-5p/DLC-1 axis., PMID:28982593
Cell-permeable capsids as universal antigen carrier for the induction of an antigen-specific CD8+ T-cell response., PMID:28851900
Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy., PMID:28842495
PGC1α Transcriptional Adaptor Function Governs Hepatitis B Virus Replication by Controlling HBcAg/p21 Protein-Mediated Capsid Formation., PMID:28768874
Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro., PMID:28647474
For research use only. Not for human or drug use.
