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Research Grade Abatacept

Catalog #:   DHE03429 Specific References (99) DATASHEET
Host species: Human
Isotype: IgG1-Fc
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHE03429

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-Fc

Clonality

Monoclonal

Target

CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, BU63, B70, CD28LG2, CTLA-4 counter-receptor B7.2, Activation B7-2 antigen, T-lymphocyte activation antigen CD86, CD86, FUN-1

Concentration

2.29 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P33681 &/or P42081

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Abatacept

Data Image
  • SDS-PAGE
    SDS PAGE for Abatacept
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis, PMID: 33053283

Abatacept: A Review in Rheumatoid Arthritis, PMID: 28608166

Abatacept for the treatment of rheumatoid arthritis, PMID: 30730220

How does abatacept really work in rheumatoid arthritis?, PMID: 29401118

Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency, PMID: 31238161

[Abatacept], PMID: 27311187

Abatacept for Severe Immune Checkpoint Inhibitor-Associated Myocarditis, PMID: 31189043

Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial, PMID: 31342624

Abatacept in interstitial lung disease associated with rheumatoid arthritis: national multicenter study of 263 patients, PMID: 33068439

Abatacept for the treatment of psoriatic arthritis, PMID: 30246575

Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis, PMID: 33029724

Abatacept in the treatment of adult dermatomyositis and polymyositis: a randomised, phase IIb treatment delayed-start trial, PMID: 28993346

Comparative effectiveness of abatacept, apremilast, secukinumab and ustekinumab treatment of psoriatic arthritis: a systematic review and network meta-analysis, PMID: 29285605

Abatacept initiation in rheumatoid arthritis and the risk of cancer: a population-based comparative cohort study, PMID: 30535094

Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients, PMID: 29422324

Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis, PMID: 33406336

Comparative effectiveness of rituximab, abatacept, and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors: prospective cohort study, PMID: 30679233

Comparative risk of malignancies and infections in patients with rheumatoid arthritis initiating abatacept versus other biologics: a multi-database real-world study, PMID: 31703717

Abatacept for Treatment of Rheumatoid Arthritis: Special Focus on the Elderly, PMID: 29651639

Abatacept in the treatment of psoriatic arthritis: biological and clinical profiles of the responders, PMID: 29737909

Abatacept in the treatment of localized scleroderma: A pediatric case series and systematic literature review, PMID: 32504991

A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis, PMID: 28133925

CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes, PMID: 32031422

The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation, PMID: 27135404

Abatacept, PMID: 19843049

Abatacept for the treatment of systemic lupus erythematosus, PMID: 26878310

Comparative efficacy and safety of tocilizumab, rituximab, abatacept and tofacitinib in patients with active rheumatoid arthritis that inadequately responds to tumor necrosis factor inhibitors: a Bayesian network meta-analysis of randomized controlled trials, PMID: 26692536

Efficacy of abatacept for Felty's syndrome, PMID: 31292638

Abatacept for rheumatoid arthritis: a Cochrane systematic review, PMID: 20080922

Abatacept in rheumatoid arthritis and the risk of cancer: a world observational post-marketing study, PMID: 31880308

Abatacept Monotherapy Versus Abatacept Plus Methotrexate for Treatment-Refractory Rheumatoid Arthritis, PMID: 29023282

Malignant Neoplasms in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors, Tocilizumab, Abatacept, or Rituximab in Clinical Practice: A Nationwide Cohort Study From Sweden, PMID: 28975211

Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production, PMID: 31994996

Practice guidelines for the use of subcutaneous abatacept, PMID: 24387951

Subcutaneous abatacept in rheumatoid arthritis: current update, PMID: 26160492

Abatacept induced granulomatous hepatitis with a sarcoidosis- like reaction: a blinded trial in mice, PMID: 31064410

Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists, PMID: 16971318

JAK1 inhibitor superior to abatacept in head-to-head RA trial, PMID: 33110224

Abatacept alleviates rheumatoid arthritis development by inhibiting migration of fibroblast-like synoviocytes via MAPK pathway, PMID: 31002160

Evaluation of abatacept in biologic-naïve patients with active rheumatoid arthritis, PMID: 20099018

Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment, PMID: 28465078

Abatacept in rheumatoid arthritis: survival on drug, clinical outcomes, and their predictors-data from a large national quality register, PMID: 31969172

Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs?, PMID: 31203226

Response to abatacept is associated with the inhibition of proteasome β1i expression in T cells of patients with rheumatoid arthritis, PMID: 32998980

Successful abatacept treatment for Felty's syndrome in a patient with rheumatoid arthritis, PMID: 33086993

Abatacept Use Is Associated with Steroid Dose Reduction and Improvement in Fatigue and CD4-Dysregulation in CVID Patients with Interstitial Lung Disease, PMID: 33223097

Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature, PMID: 31027870

Gene expression regulated by abatacept associated with methotrexate and correlation with disease activity in rheumatoid arthritis, PMID: 32760165

Abatacept as a successful therapy for myositis—a case-based review, PMID: 24493331

Abatacept retention and clinical outcomes in rheumatoid arthritis: real-world data from the German cohort of the ACTION study and a comparison with other participating countries, PMID: 31300979

Abatacept versus tocilizumab for the treatment of rheumatoid arthritis in TNF inhibitor inadequate responders: study protocol of the SUNSTAR randomised controlled open-label superiority trial., PMID:40527572

CD28 and ICOS in immune regulation: Structural insights and therapeutic targeting., PMID:40527414

A randomized, double-blind, placebo-controlled trial of abatacept for the treatment of relapsing, non-severe, granulomatosis with polyangiitis., PMID:40506793

Abatacept and multiple therapeutic bronchoscopies as salvage therapy for refractory tracheobronchial inflammation and stenosis in GPA., PMID:40506105

Optimal GVHD Prophylaxis., PMID:40488825

Allogeneic Transplantation for Older Adults., PMID:40488822

Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial., PMID:40480650

Immune Checkpoint Inhibitors for Patients With Preexisting Autoimmune Neurologic Disorders., PMID:40465294

Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future., PMID:40463417

Autoantibodies as prognostic markers in rheumatoid arthritis., PMID:40458132

Switching to IL-6 inhibitors or abatacept in elderly patients with rheumatoid arthritis achieving low disease activity with jak inhibitors: a pilot study., PMID:40455033

Multi-omics analysis of Helicobacter pylori-associated gastric cancer identifies hub genes as a novel therapeutic biomarker., PMID:40445003

FDA Approval Summary: Abatacept for prophylaxis of acute graft versus host disease., PMID:40435096

Interplay of Belatacept Immunosuppression and Maribavir Antiviral Activity in Recurrent CMV Viremia: Clinical Implications and Literature Review., PMID:40431608

New Challenging Systemic Therapies for Juvenile Scleroderma: A Comprehensive Review., PMID:40430462

β-Cell Function Derived From Routine Clinical Measures Reports and Predicts Treatment Response to Immunotherapy in Recent-Onset Type 1 Diabetes., PMID:40424079

Current Activity Trends and Outcomes in Hematopoietic Cell Transplantation and Cellular Therapy - A report from the CIBMTR., PMID:40398621

Disseminated cat-scratch disease during abatacept therapy for rheumatoid arthritis in an older patient: A case report and review of the literature., PMID:40379021

Humoral immunogenicity after vaccination with the fourth dose of COVID-19 in patients with immunomediated inflammatory diseases., PMID:40378626

Belatacept Conversion in Kidney Transplant Recipients with Congestive Heart Failure: Survival and 30-Day Readmission Outcomes., PMID:40374481

Mechanism and clinical utility of abatacept in the treatment of rheumatoid arthritis., PMID:40347194

The Role of Abatacept on Inflammation and Fibrosis in Hypochlorous Acid-Induced Fibrosis Mice., PMID:40344312

Abatacept-induced lupus erythematosus tumidus: A case report and literature review., PMID:40342196

Cost evaluation in head and neck cancer clinical trials: implications for high-value care., PMID:40339439

Preclinical mouse models of immune checkpoint inhibitor-associated myocarditis., PMID:40335724

Changes in Chronic Graft-versus-Host Disease Treatment Over Time: A 15-Years Survey Within Allogeneic Hematopoietic Stem Cell Transplant Centers in Germany, Austria, and Switzerland., PMID:40334913

Abatacept for acute graft versus host disease prophylaxis in children with sickle cell disease patients undergoing HLA identical sibling hematopoietic stem cell transplantation., PMID:40301664

SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality-a secondary analysis of the ACTIV-1 trial., PMID:40297751

Toxoplasma Gondii Replication During Belatacept Treatment in Kidney Transplantation: A Case Report and a Review of the Literature., PMID:40282351

Post-transplant cyclophosphamide, abatacept, and vedolizumab to prevent GVHD after hematopoietic stem cells transplantation in children with acute leukemia: results of a prospective trial., PMID:40281208

Non-TNFi biologic and targeted synthetic DMARDs in rheumatoid arthritis-associated interstitial lung disease: A propensity score-matched, active-comparator, new-user study., PMID:40280051

Short Form-36 psychometric properties in idiopathic inflammatory myopathies: reliability, validity, and responsiveness., PMID:40279268

Real-World Evidence in New Drug and Biologics License Application Approvals During Fiscal Years 2020-2022., PMID:40276902

Abatacept for the treatment of myositis-associated interstitial lung disease (ATtackMy-ILD)., PMID:40272902

Macrophage-Tased Dual-Phase T Cell Immunomodulation to Combat Transplant Rejection., PMID:40264278

Transitional and CD21- PD-1+ B cells are associated with remission in early rheumatoid arthritis., PMID:40259340

Recommendations for the Use of Disease-Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review., PMID:40256995

Characterising infusion/injection-related reactions in patients with rheumatoid arthritis treated with biologic agents., PMID:40249052

Immune Checkpoint Inhibitor Myocarditis and Left Ventricular Systolic Dysfunction., PMID:40246381

Macrophage requirements for abatacept response in rheumatoid arthritis., PMID:40242906

Long-Term Outcomes of Belatacept Versus Tacrolimus Following T-Cell Depleting Induction in Adult Kidney Transplantation., PMID:40232892

Janus kinase inhibitors show a longer drug survival than biologics in a real-world cohort of patients with rheumatoid arthritis - a retrospective analysis from the RHADAR database., PMID:40232336

Impact of csDMARDs vs. b/tsDMARDs on the Prognosis of Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Multicenter, Retrospective Study., PMID:40218150

Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors., PMID:40199607

Emerging therapeutics in the management of food allergy., PMID:40189990

Updates in Diagnosis and Treatment of Immune Checkpoint Inhibitor Myocarditis., PMID:40178703

Verification of unmet medical needs in patients with juvenile idiopathic arthritis in Japan., PMID:40160024

Successful treatment of rheumatoid arthritis complicated by anti-Jo-1 antibody-positive myopathy with abatacept: A case report., PMID:40159152

Abatacept, Golimumab, and Sarilumab as Selected Bio-Originator Disease-Modifying Antirheumatic Drugs with Diverse Mechanisms of Action in Their Current Use in Treatment., PMID:40142915

Datasheet

Document Download

Research Grade Abatacept.pdf

 

$ 484
Product specifications
100 μg 484 1 mg 1932

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Research Grade Abatacept [DHE03429]
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