Catalog No.
EHC29901
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Val492
Predicted molecular weight
56.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>80% as determined by SDS-PAGE.
Accession
P08069
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor
Insulin- Like Growth Factor-1 as Brain-Body Connector., PMID:40442384
CircRNA-NOLC1 mediates Insulin-like growth factor 1 receptor via performing as a ceRNA of miRNA-140-5p to facilitate testicular germ cell tumor advancement., PMID:40367575
Disruption of Man-6-P-Dependent Sorting to Lysosomes Confers IGF1R-Mediated Apoptosis Resistance., PMID:40332073
The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure., PMID:40327402
Cytidinyl/Cationic Lipid Encapsulating Insulin-Like Growth Factor 1 Receptor siRNA for Hepatocellular Carcinoma Therapy., PMID:40289542
Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease., PMID:40257057
Tyrosine kinase inhibitors in Ewing's sarcoma: a systematic review., PMID:40251562
Nicotine-driven enhancement of tumor malignancy in triple-negative breast cancer via additive regulation of CHRNA9 and IGF1R., PMID:40244072
Gene proteins, growth factors/their receptors in the wall of chronic calculous cholecystitis-affected gallbladder children., PMID:40221697
Hepatocyte-Enriched miRNA-193b-3p Promotes Hepatitis B Virus Replication by Dual Activation of Viral Core Promoter Activity and Autophagy Induction by Targeting IGF-1R., PMID:40195593
[Expression of NFAT5 and IGF1R in nasopharyngeal carcinoma tissues and analysis of clinical characteristics]., PMID:40166875
Comprehensive Analysis of Uric Acid and Myasthenia Gravis: IGF1R as a Protective Factor and Potential Therapeutic Target., PMID:40152081
IGF1R activates FOXP3-β-catenin signaling to promote breast cancer development., PMID:40055251
Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas., PMID:40038716
Protein profiling uncovers IGF-1R inhibition potential of 3-(2-furoyl)-indole scaffolds in hepatocellular carcinoma., PMID:40028717
Identification and Evaluation of IGF1R and Its Associated Proteins as Targets and Design of Novel Inhibitors for Cancer Therapy., PMID:40023828
Picropodophyllotoxin alters EMT in neuroblastoma via inhibition of surface receptors IGF1R and ALK., PMID:40015087
IGF1R/ARRB1 Mediated Regulation of ERK and cAMP Pathways in Response to Aβ Unfolds Novel Therapeutic Avenue in Alzheimer's Disease., PMID:39969678
Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway., PMID:39921429
Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy., PMID:39914384
Controversies Surrounding IGF-I Receptor Involvement in Thyroid-Associated Ophthalmopathy., PMID:39909461
Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma., PMID:39885295
Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor., PMID:39821041
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling., PMID:39809772
Echinacoside promotes collagen synthesis and survival via activation of IGF-1 signaling to alleviate UVB-induced dermal fibroblast photoaging., PMID:39780317
Worse survival of hepatocellular cancer patients with membranous insulin receptor overexpression., PMID:39775131
IGF2-IGF1R signaling inhibition delays the growth of IGF2-high colorectal cancer by modulating MDSCs., PMID:39756209
Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts., PMID:39747159
RBM47 as a potential therapeutic target for thyroid-associated ophthalmopathy., PMID:39746275
IGF1R Enhances Calcium Oxalate Monohydrate-Induced Epithelial-Mesenchymal Transition by Reprogramming Metabolism via the JAK2/STAT3 Signaling., PMID:39744436
Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis., PMID:39744430
Dual silencing of integrin αvβ3 receptor and insulin-like growth factor 1 receptor using mPEG-PCL/DDAB hybrid nanoparticle loaded siRNA in breast cancer therapy: An in vitro study on MCF-7 cells., PMID:39743068
Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells., PMID:39723207
Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathway., PMID:39704170
Association between insulin-associated gene polymorphisms and new-onset diabetes mellitus in statin-treated patients., PMID:39614667
β1-integrin controls IGF-1R internalization and intracellular signaling., PMID:39608716
Advances of IGF-1R inhibitors in Graves' ophthalmopathy., PMID:39578269
Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway which is dependent on low IGF1R level., PMID:39572596
Establishing a new human lung squamous cell carcinoma cell line, OMUL-1, expressing insulin-like growth factor 1 receptor and programmed cell death ligand 1., PMID:39552203
Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy., PMID:39545420
Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R., PMID:39521729
Regulated N-glycosylation controls chaperone function and receptor trafficking., PMID:39509507
CHS-Ⅳa activates the IGF1R/PI3K signal pathway with inhibited pyroptosis of endometrial stromal cells and progress of endometriosis., PMID:39488924
Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells., PMID:39419341
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons., PMID:39413164
Distinguishing Genetic Alterations Versus (Epi)Mutations in Silver-Russell Syndrome and Focus on the IGF1R Gene., PMID:39412159
Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling., PMID:39394189
Kinase library screening identifies IGF-1R as an oncogenic vulnerability in intrahepatic cholangiocarcinoma stem-like cells., PMID:39369614
Insulin-like growth factor 1 receptor expression correlates with programmed death ligand 1 expression and poor survival in non-small cell lung cancer., PMID:39365756
Recent update on IGF-1/IGF-1R signaling axis as a promising therapeutic target for triple-negative breast cancer., PMID:39357179
For research use only. Not for human or drug use.
