Catalog No.
PHF79501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human XIAP (Met1-Ser497).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ILP,IAP-like protein,X-linked inhibitor of apoptosis protein,IAP-3,hILP,X-linked IAP,Baculoviral IAP repeat-containing protein 4,Inhibitor of apoptosis protein 3,RING-type E3 ubiquitin transferase XIAP,E3 ubiquitin-protein ligase XIAP,API3,XIAP,hIAP-3,hIAP3,BIRC4,IAP3
Purification
Purified by antigen affinity column.
Accession
P98170
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
In Silico Molecular Docking of 2-Hydroxyanthraquinone-Substituted Spiro-/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells., PMID:40296721
Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies., PMID:39596160
An 8-aminoquinoline-naphthyl copper complex causes apoptotic cell death by modulating the expression of apoptotic regulatory proteins in breast cancer cells., PMID:38908670
Clinical features and lymphocyte immunophenotyping analysis in primary immunodeficiency patients with non-transplant lymphoproliferative disorders., PMID:38838929
CD62-L down-regulation after L18-MDP stimulation as a complementary flow cytometry functional assay for the diagnosis of XIAP deficiency., PMID:38770762
Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function., PMID:38569602
Maternal diet during gestation affect prostatic tissue component in SHR/Izm offspring., PMID:38032025
TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP., PMID:37944651
Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life., PMID:37938347
Multi-kinase compensation rescues EGFR knockout in a cell line model of head and neck squamous cell carcinoma., PMID:37844343
Alemtuzumab-based reduced-intensity conditioning for XIAP deficiency., PMID:37534620
β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells., PMID:37373014
Refractory atopic dermatitis in a child with hypomorphic mutation in XIAP gene and low serum IgG., PMID:37334779
Clinical Features and Genetic Analysis of Taiwanese Primary Immunodeficiency Patients with Prolonged Diarrhea and Monogenetic Inflammatory Bowel Disease., PMID:37202577
A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade., PMID:36875111
Inhibitor of apoptosis proteins antagonist SM164 ameliorates experimental MPO-ANCA-associated vasculitis via enhancing fatty acid oxidation in neutrophils., PMID:36308438
When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders., PMID:36209991
Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma., PMID:35224804
β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models., PMID:34638895
Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death., PMID:34634376
Supplementation of oleic acid, stearic acid, palmitic acid and β-hydroxybutyrate increase H3K9me3 in endometrial epithelial cells of cattle cultured in vitro., PMID:34560342
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369
IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells., PMID:34080646
Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer., PMID:33996561
Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant., PMID:33898931
High ROS Production by Celecoxib and Enhanced Sensitivity for Death Ligand-Induced Apoptosis in Cutaneous SCC Cell Lines., PMID:33807213
Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant., PMID:33257690
Targeting X chromosome-linked inhibitor of apoptosis protein in mucoepidermoid carcinoma of the head and neck: A novel therapeutic strategy using nitidine chloride., PMID:32901343
Expanding clinical spectrum of female X-linked lymphoproliferative syndrome 2., PMID:32686289
Galectin-3 mediates survival and apoptosis pathways during Trypanosoma cruzi-host cell interplay., PMID:32535113
The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein., PMID:32290047
Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cells., PMID:32232903
Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia., PMID:32141025
Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma., PMID:32054850
The Use of Antibody Arrays in the Discovery of New Plasma Biomarkers for Endometriosis., PMID:32016799
Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways., PMID:31831875
The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma., PMID:31521140
Novel Carbazole-Piperazine Hybrid Small Molecule Induces Apoptosis by Targeting BCL-2 and Inhibits Tumor Progression in Lung Adenocarcinoma in Vitro and Xenograft Mice Model., PMID:31450709
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721
Immunity to X-linked inhibitor of apoptosis protein (XIAP) in malignant melanoma and check-point blockade., PMID:31317218
Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy., PMID:31266830
Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid., PMID:31248140
Overlapping dermatologic diagnoses in severe Crohn's disease with duel genetic mutations., PMID:31209857
Nimbolide induced apoptosis by activating ERK-mediated inhibition of c-IAP1 expression in human hepatocellular carcinoma cells., PMID:29962003
G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection., PMID:29864441
A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity., PMID:29679556
Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells., PMID:29663486
Evidence for the role of INSL3 on sperm production in boars by passive immunisation., PMID:29575065
Identification of prefrontal cortex protein alterations in Alzheimer's disease., PMID:29541381
Analysis of Genes Associated With Monogenic Primary Immunodeficiency Identifies Rare Variants in XIAP in Patients With Crohn's Disease., PMID:29501442
For research use only. Not for human or drug use.
