Catalog No.
PHE61101
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MASP1 (His20-Pro434).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Mannose-binding lectin-associated serine protease 1,CRARF,PRSS5,CRARF1,Mannose-binding protein-associated serine protease,Ra-reactive factor serine protease p100,Complement factor MASP-3,RaRF,MASP1,Mannan-binding lectin serine protease 1,Serine protease 5,Complement-activating component of Ra-reactive factor,MASP-1
Purification
Purified by antigen affinity column.
Accession
P48740
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury., PMID:38807149
CL-11 circulates in serum as functionally distinct isoforms., PMID:38466278
Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway-mediated disorders., PMID:38022610
Pathogenic bacteria defense and complement activation function analysis of Collectin-10 from Hexagrammos otakii., PMID:37488038
Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model., PMID:36032172
In vivo study of the immune response to bioengineered spider silk spheres., PMID:35931709
Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency., PMID:35673952
Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis., PMID:35491890
Lectin and alternative complement pathway activation in cutaneous manifestations of IgA-vasculitis: A new target for therapy?, PMID:35121432
MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19., PMID:33729332
The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis., PMID:33274243
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D., PMID:32153567
Complement Regulation and Immune Evasion by Hepatitis C Virus., PMID:30593637
Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice., PMID:29892304
Human anti-thrombospondin type 1 domain-containing 7A antibodies induce membranous nephropathy through activation of lectin complement pathway., PMID:29769410
Lectin complement pathway proteins in healthy individuals., PMID:27925159
Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing., PMID:27707997
Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1., PMID:27577570
Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients., PMID:27404661
TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2., PMID:25359215
The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy., PMID:24291022
A novel assay to quantitate MASP-2/ficolin-3 complexes in serum., PMID:23142462
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components., PMID:22670777
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2., PMID:22511776
An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1)., PMID:22301270
Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement., PMID:21943708
Serum concentration and interaction properties of MBL/ficolin associated protein-1., PMID:21035894
Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis., PMID:20870940
Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system., PMID:20673767
A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation., PMID:20053996
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot., PMID:20002787
MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation., PMID:19939495
C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation., PMID:18977695
Environmental conditions impinge on dragline silk protein composition., PMID:18828841
[Prokaryotic expression of N terminal fragment of mannan-binding lectin associated serine protease-1]., PMID:18538079
Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis., PMID:17539966
Second-generation nanofiltered plasma-derived mannan-binding lectin product: process and characteristics., PMID:17456158
Gene-environment interactions in multiple sclerosis: innate and adaptive immune responses to human endogenous retrovirus and herpesvirus antigens and the lectin complement activation pathway., PMID:17113160
Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2., PMID:16670774
Activation of the lectin complement pathway in Henoch-Schönlein purpura nephritis., PMID:15685507
Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus., PMID:12619800
Activation of the lectin complement pathway by H-ficolin (Hakata antigen)., PMID:11907111
Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis., PMID:11684563
Isolation, cloning and functional characterization of porcine mannose-binding lectin., PMID:11298833
Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations., PMID:10913141
[Immunology in the medical practice. XXVII. Mannose-binding lectin, an important link for nonspecific or hereditary immune reaction]., PMID:10897301
Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19., PMID:10878362
Opsonic complement system of the solitary ascidian, Halocynthia roretzi., PMID:10426432
Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy., PMID:9719152
A second serine protease associated with mannan-binding lectin that activates complement., PMID:9087411
For research use only. Not for human or drug use.
