Catalog No.
PHD80301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GRN (Thr18-Asp363).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PC cell-derived growth factor,Granulin G,Epithelin precursor,Epithelin-1,Granulin A,Acrogranin,Progranulin,Granulin F,Proepithelin,PGRN,Glycoprotein of 88 Kda,GRN,Granulin C,Granulin E,Granulin precursor,PEPI,PCDGF,Granulin D,Glycoprotein 88,Epithelin-2,GP88,Granulin B
Purification
Purified by antigen affinity column.
Accession
P28799
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Single-cell transcriptomic profiling reveals dysregulation of B-cell subset function in patients with chronic hepatitis B., PMID:40489024
Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation., PMID:40226614
Single-cell multiomic comparison of mouse and rat spermatogenesis reveals gene regulatory networks conserved for over 20 million years., PMID:40086448
A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy., PMID:40020677
Mild cognitive impairment and early Alzheimer's disease eligibility for disease modification therapies in a tertiary centre for cognitive disorders: A simultaneous real-word study on aducanumab and lecanemab., PMID:39498901
Progranulin mediates the onset of pristane induced systemic lupus erythematosus., PMID:39252120
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results., PMID:38745011
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis., PMID:38689292
Stochastic modeling of a gene regulatory network driving B cell development in germinal centers., PMID:38547073
Phase 1 study of latozinemab in progranulin-associated frontotemporal dementia., PMID:38356474
Altered plasma protein profiles in genetic FTD - a GENFI study., PMID:37968725
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia., PMID:37322482
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes., PMID:37100087
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging., PMID:36527486
Neurons with Cat's Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions., PMID:35327628
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency., PMID:35019161
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression., PMID:35013174
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study., PMID:34838088
Progranulin correlated with rapid progressive interstitial lung disease in dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody., PMID:34718893
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities., PMID:34366786
Risk factors for esophageal cancer in a high-incidence area of Malawi., PMID:34342770
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation., PMID:33384578
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes., PMID:32778941
Osteocytes control myeloid cell proliferation and differentiation through Gsα-dependent and -independent mechanisms., PMID:32557809
Development of disease-modifying drugs for frontotemporal dementia spectrum disorders., PMID:32203398
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling., PMID:31585000
Progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders: A preliminary study., PMID:31502765
Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment., PMID:31491449
Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice., PMID:31467413
C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation., PMID:31266542
Using ATAC-seq and RNA-seq to increase resolution in GRN connectivity., PMID:30948003
A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders., PMID:30939191
New Antibody-Free Mass Spectrometry-Based Quantification Reveals That C9ORF72 Long Protein Isoform Is Reduced in the Frontal Cortex of Hexanucleotide-Repeat Expansion Carriers., PMID:30210275
Transcriptome profiling in blood before and after hepatitis B vaccination shows significant differences in gene expression between responders and non-responders., PMID:30205979
Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice., PMID:30180904
Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality., PMID:29386014
Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis., PMID:29340960
Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein., PMID:29096020
Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration., PMID:29044416
Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration., PMID:28877758
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations., PMID:28828399
Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas., PMID:28823651
Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma., PMID:28601093
Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder., PMID:28100408
Potential of Theranostic Target Mining in the Development of Novel Diagnostic and Therapeutic Products in Oncology: Progranulin/GP88 as a Therapeutic and Diagnostic Target for Breast and Lung Cancers., PMID:30695312
Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model., PMID:27693922
Progranulin and granulin-like protein as novel VEGF-independent angiogenic factors derived from human mesothelioma cells., PMID:27345409
Targeting microglia for the treatment of Alzheimer's Disease., PMID:27100611
Orchestration of B lymphoid cells and their inner myeloid by Bach., PMID:26894991
Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae., PMID:26864722
For research use only. Not for human or drug use.
