Catalog No.
PHD14601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ALOX15 (Lys170-Leu312).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Arachidonate omega-6 lipoxygenase,Arachidonate 12-lipoxygenase,leukocyte-type,Hepoxilin A3 synthase Alox15,12-LOX,15-LOX-1,15-LOX,Arachidonate 15-lipoxygenase,Polyunsaturated fatty acid lipoxygenase ALOX15,12/15-lipoxygenase,Linoleate 13S-lipoxygenase,LOG15,ALOX15
Purification
Purified by antigen affinity column.
Accession
P16050
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15., PMID:37468019
12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis., PMID:37143678
Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice., PMID:37018853
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA., PMID:36423907
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease., PMID:36153599
Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes., PMID:35767947
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation., PMID:34762602
Blood Transcriptomes of Anti-SARS-CoV-2 Antibody-Positive Healthy Individuals Who Experienced Asymptomatic Versus Clinical Infection., PMID:34675930
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation., PMID:32768245
Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents., PMID:30923181
Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases., PMID:30658649
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease., PMID:29992788
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo., PMID:28239665
Variable exon usage of differentially-expressed genes associated with resistance of sheep to Teladorsagia circumcincta., PMID:26330386
Resolution of PMA-induced skin inflammation involves interaction of IFN-γ and ALOX15., PMID:23818745
Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia., PMID:23382512
Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2)., PMID:19643136
Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators., PMID:18258795
For research use only. Not for human or drug use.
