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Research Grade Idarucizumab

Catalog #:   DGK09701 Specific References (99) DATASHEET
Host species: Humanized
Isotype: Fab-G1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DGK09701

Expression system

Mammalian Cells

Species reactivity

General

Host species

Humanized

Isotype

Fab-G1-kappa

Clonality

Monoclonal

Target

Dabigatran Etexilate Mesylate

Concentration

0.56 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

CAS: 211915-06-9

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

aDabi-Fab, anti-dabigatran, antidote for dabigatran, CAS: 1362509-93-0

Clone ID

Idarucizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Idarucizumab
References

Idarucizumab: What Should We Know?, PMID: 28950812

Idarucizumab for Dabigatran Reversal, PMID: 26095746

Idarucizumab for Dabigatran Reversal - Full Cohort Analysis, PMID: 28693366

Idarucizumab, PMID: 27789932

Idarucizumab for the Reversal of Dabigatran, PMID: 28110992

Idarucizumab, PMID: 29999814

Idarucizumab for Reversing Dabigatran-Induced Anticoagulation: A Systematic Review, PMID: 27175894

idarucizumab (PRAXBIND°). Don't rely too heavily on this dabigatran antidote, PMID: 30715821

Idarucizumab: A Review as a Reversal Agent for Dabigatran, PMID: 27388764

Idarucizumab for Reversal of Dabigatran-Associated Anticoagulation, PMID: 27389324

Idarucizumab (Praxbind) Formulary Review, PMID: 27465000

Idarucizumab for Dabigatran-Related Gastrointestinal Bleeds, PMID: 30715945

Idarucizumab for Reversal of Dabigatran: Single-Center Real-World Experience, PMID: 30203330

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons, PMID: 30686041

Idarucizumab: First Global Approval, PMID: 26578027

Spotlight on idarucizumab and its potential for the reversal of anticoagulant effects of dabigatran, PMID: 27274201

Idarucizumab Reverses Dabigatran Anticoagulant Activity in Healthy Chinese Volunteers: A Pharmacokinetics, Pharmacodynamics, and Safety Study, PMID: 32691242

Evidence supporting idarucizumab for the reversal of dabigatran, PMID: 27697436

Evidence Supporting Idarucizumab for the Reversal of Dabigatran, PMID: 27568285

Idarucizumab for dabigatran reversal in daily clinical practice: A case series, PMID: 32175987

Reversal of dabigatran by idarucizumab: when and how?, PMID: 27166653

Idarucizumab before reperfusion therapy in stroke patients on dabigatran: No more cold sweat, PMID: 32079736

Dabigatran reversal with idarucizumab prior to lung transplantation, PMID: 33150658

Assessment of patients post reversal with idarucizumab, PMID: 30120649

[Experience with idarucizumab as a reverse agent of dabigatran], PMID: 32841148

Use of idarucizumab in reversing dabigatran anticoagulant effect: a critical appraisal, PMID: 30174430

Reversal of direct oral anticoagulants: Guidance from the Anticoagulation Forum, PMID: 30916798

Idarucizumab for Reversion of Anticoagulant Effect in Daily Practice, PMID: 31470446

Three-month use of idarucizumab at Christchurch Hospital through the emergency department and MedChartTM, PMID: 31352470

Idarucizumab: The Antidote for Reversal of Dabigatran, PMID: 26700008

Idarucizumab (Praxbind)--an antidote for dabigatran, PMID: 26583604

Idarucizumab for Reversal of Dabigatran in Early/Emergency Surgeries: A Case Series, PMID: 31662218

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society, PMID: 30703431

Idarucizumab, a Humanized, Monoclonal Antibody Fragment for Immediate Reversal of Dabigatran, PMID: 26894245

Idarucizumab for Dabigatran Reversal in the Management of Patients With Gastrointestinal Bleeding, PMID: 30586692

Global Use of Idarucizumab in Clinical Practice: Outcomes of the RE-VECTO Surveillance Program, PMID: 31470445

Real-world experience with reversal of dabigatran by idarucizumab, PMID: 33227654

Dabigatran Reversal With Idarucizumab in Patients With Renal Impairment, PMID: 31582135

Stroke reperfusion therapy following dabigatran reversal with idarucizumab in a national cohort, PMID: 32079737

Idarucizumab for Emergency Reversal of Anticoagulant Effects of Dabigatran: Interim Results of a Japanese Post-Marketing Surveillance Study, PMID: 32152956

Anticoagulation Reversal, PMID: 30037445

Idarucizumab in the 'real world': possibilities and limitations, PMID: 30364967

Idarucizumab, a specific reversal agent for dabigatran: mode of action, pharmacokinetics and pharmacodynamics, and safety and efficacy in phase 1 subjects, PMID: 27707528

Performance of idarucizumab as antidote of dabigatran in daily clinical practice, PMID: 30339226

Real World Outcomes Associated with Idarucizumab: Population-Based Retrospective Cohort Study, PMID: 31332727

Idarucizumab and Factor Xa Reversal Agents: Role in Hospital Guidelines and Protocols, PMID: 27569673

Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran, PMID: 31050868

Drugs for atrial fibrillation, PMID: 31599871

Idarucizumab: Clinical Role of a Novel Reversal Agent for Dabigatran, PMID: 27477871

Idarucizumab and factor Xa reversal agents: role in hospital guidelines and protocols, PMID: 27697438

Diagnostics and management of direct oral anticoagulants-induced bleeding., PMID:40493531

Sonorheometry parameters during dabigatran reversal with idarucizumab for major bleeding., PMID:40466460

2025 Guidelines for direct oral anticoagulants: a practical guidance on the prescription, laboratory testing, peri-operative and bleeding management., PMID:40448969

Intravenous Dabigatran Provides Effective, Reversible Anticoagulation for Cardiopulmonary Bypass in a Sheep Model., PMID:40424620

Reversal of anticoagulation in patients with intracerebral haemorrhage related to oral anticoagulants: State of the evidence., PMID:40401655

Safety of direct oral anticoagulants reversal agents in older patients: an analysis of individual case safety reports of adverse drug reaction from VigiBase®., PMID:40192996

Andexanet Alfa in Urgent Cardiac Surgery: A Case Report of Edoxaban Reversal for Acute Hemopericardium., PMID:40158195

Pro: The Patient With the Recent Intake of DOACs Problems Are Solved With the Approval of Reversal Agents., PMID:39984366

Two Cases of Pseudoelevation of Plasma Thrombin Time Levels., PMID:39967546

Con: The Patient With Recent Intake of Direct Oral Anticoagulants-Problems Are Not Solved With the Approval of Reversal Agents., PMID:39952835

Correction of the effect of direct oral and parenteral anticoagulants in hemorrhagic stroke., PMID:39907674

Intravenous thrombolysis for patients with acute ischemic stroke while receiving a direct oral anticoagulant: A systematic review and meta-analysis., PMID:39831680

Comparative Outcomes of Warfarin vs. Direct Oral Anticoagulants (DOACs) in Anticoagulant-Related Gastrointestinal Bleeding: A Single-Center Study., PMID:39744289

Bleeding Risk of Anticoagulation Reversal Strategies Before Heart Transplantation: A Retrospective Comparative Cohort Study., PMID:39590209

Incidence of Venous Thromboembolism Post-Oral Anticoagulation Reversal in Intracranial Hemorrhage Patients., PMID:39563016

Reversal of dabigatran and apixaban-induced coagulopathy using idarucizumab, fibrinogen, and prothrombin complex concentrate: A case report., PMID:39524786

[Current Management of Patients with Proximal Femur Fractures Receiving Antiplatelet and Anticoagulant Therapy]., PMID:39496190

Strategies for Perioperative Anticoagulant Reversal in Orthopedic Surgery: A Review., PMID:39467789

Intravenous thrombolysis following dabigatran reversal in a patient with acute embolic stroke after atrial fibrillation ablation., PMID:39416242

Thrombolysis After Dabigatran Reversal for Acute Ischemic Stroke: A National Registry-Based Study and Meta-Analysis., PMID:39255429

Anticoagulation management for cardiopulmonary bypass using TEG® 6 s in a patient receiving both heparin and dabigatran., PMID:39230640

Thrombolysis for Ischemic Stroke Despite Recent Ingestion of Direct Oral Anticoagulants - A Growing Dilemma Also in India., PMID:39196805

Perioperative Management of Patients Taking Direct Oral Anticoagulants: A Review., PMID:39133476

Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH., PMID:39029742

Dabigatran accumulation in acute kidney injury: is more better than less to prevent bleeding? A case report., PMID:39020273

Anticoagulation and Antiplatelet Regimen in Cardiac Transplant. Clinical Characteristics, Outcomes, and Blood Product Transfusion., PMID:38952201

Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine)., PMID:38926082

[Overdosing of direct oral anticoagulants]., PMID:38916655

Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update., PMID:38817549

ANMCO/SIMEU consensus document on the use of reversal agents for antithrombotic therapies in patients with ongoing bleeding or at high risk of haemorrhagic events., PMID:38784674

Reversal or Repletion Treatment Strategies and Outcomes of Patients With Major Bleeding Events Managed in the Emergency Department: Large Real-Life Investigation in the Northwestern Healthcare District of Tuscany., PMID:38781079

Coagulation Tests and Reversal Agents in Patients Treated with Oral Anticoagulants: The Challenging Scenarios of Life-Threatening Bleeding and Unplanned Invasive Procedures., PMID:38730979

Is there a role for the laboratory monitoring in the management of specific antidotes of direct oral anticoagulants?, PMID:38626592

Balfaxar: Another four-factor PCC for warfarin reversal., PMID:38412268

Direct oral anticoagulants in trauma patients., PMID:38390987

Antidote vs. unspecific hemostatic agents for the management of direct oral anticoagulant-related bleeding in trauma., PMID:38390922

Cardiac Tamponade and Duodenal Hemorrhage Caused by Inappropriate Use of Dabigatran in a Patient With End-Stage Renal Failure: A Case Report., PMID:38371033

Latest advances in the reversal strategies for direct oral anticoagulants., PMID:38350629

Barriers in Access to Idarucizumab in Ischemic Stroke in a Middle-Income Country., PMID:38235022

Treatment of atrial fibrillation., PMID:38180321

Dabigatran pharmacokinetic-pharmacodynamic in sheep: Informing dose for anticoagulation during cardiopulmonary bypass., PMID:38171494

Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta-Analysis., PMID:38108256

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines., PMID:38043043

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines., PMID:38033089

Retrospective Observational Study of Patients With Subdural Hematoma Treated With Idarucizumab., PMID:38028276

Reversing dabigatran effect with idarucizumab to enable intravenous thrombolysis in patients with acute ischaemic stroke - a single centre experience., PMID:37955597

Efficacy and Safety of Novel Oral Anticoagulants in Atrial Fibrillation: A Systematic Review., PMID:37927673

Evidence-based Management of Major Bleeding in Patients Receiving Direct Oral Anticoagulants: An Updated Narrative Review on the Role of Specific Reversal Agents., PMID:37872658

Treatment of dabigatran intoxication in critically ill patients with Acute Kidney Injury: The role of Sustained Low-Efficiency Dialysis., PMID:37853619

Datasheet

Document Download

Research Grade Idarucizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Idarucizumab [DGK09701]
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