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Research Grade Obinutuzumab

Catalog #:   DHC90704 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC90704

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P11836

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

GA101, RG7159, RO5072759, afutuzumab, CAS: 949142-50-1

Clone ID

Obinutuzumab

Data Image
  • Bioactivity
    Detects Human CD20/MS4A1 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Obinutuzumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

A tale of two antibodies: obinutuzumab versus rituximab, PMID: 29741753

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions, PMID: 31166681

Obinutuzumab for the First-Line Treatment of Follicular Lymphoma, PMID: 28976863

Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial, PMID: 32305093

Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (CLL14): follow-up results from a multicentre, open-label, randomised, phase 3 trial, PMID: 32888452

Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial, PMID: 30522969

Obinutuzumab plus bendamustine versus bendamustine monotherapy in patients with rituximab-refractory indolent non-Hodgkin lymphoma (GADOLIN): a randomised, controlled, open-label, multicentre, phase 3 trial, PMID: 27345636

Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions, PMID: 24401022

Obinutuzumab, PMID: 29999701

Immunochemotherapy With Obinutuzumab or Rituximab for Previously Untreated Follicular Lymphoma in the GALLIUM Study: Influence of Chemotherapy on Efficacy and Safety, PMID: 29856692

Comparison of acalabrutinib plus obinutuzumab, ibrutinib plus obinutuzumab and venetoclax plus obinutuzumab for untreated CLL: a network meta-analysis, PMID: 32862749

The role of obinutuzumab in the management of follicular lymphoma, PMID: 31538821

Venetoclax-obinutuzumab: harnessing complexity, PMID: 32163557

Acalabrutinib plus Obinutuzumab in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia, PMID: 31915195

Obinutuzumab or Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Previously Untreated Diffuse Large B-Cell Lymphoma, PMID: 28796588

Obinutuzumab combined with lenalidomide for relapsed or refractory follicular B-cell lymphoma (GALEN): a multicentre, single-arm, phase 2 study, PMID: 31296423

Obinutuzumab vs rituximab for advanced DLBCL: a PET-guided and randomized phase 3 study by LYSA, PMID: 33211799

Overall Survival Benefit in Patients With Rituximab-Refractory Indolent Non-Hodgkin Lymphoma Who Received Obinutuzumab Plus Bendamustine Induction and Obinutuzumab Maintenance in the GADOLIN Study, PMID: 29584548

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax, PMID: 32206772

Obinutuzumab plus Lenalidomide (GALEN) for the treatment of relapse/refractory aggressive lymphoma: a phase II LYSA study, PMID: 30291335

Obinutuzumab in follicular lymphoma, PMID: 28276536

Phase 1b study of venetoclax-obinutuzumab in previously untreated and relapsed/refractory chronic lymphocytic leukemia, PMID: 30862645

CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies, PMID: 29716920

Zanubrutinib (BGB-3111) plus obinutuzumab in patients with chronic lymphocytic leukemia and follicular lymphoma, PMID: 33022066

Obinutuzumab for the treatment of indolent lymphoma, PMID: 27117452

Ibrutinib, obinutuzumab, and venetoclax in relapsed and untreated patients with mantle cell lymphoma: a phase 1/2 trial, PMID: 33181832

Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study, PMID: 25634683

Clinical application of obinutuzumab for treating chronic lymphocytic leukemia, PMID: 31692500

Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma, PMID: 31693429

Obinutuzumab for B-cell malignancies, PMID: 24856933

Obinutuzumab in Combination with Chemotherapy for the First-Line Treatment of Patients with Advanced Follicular Lymphoma : An Evidence Review Group Evaluation of the NICE Single Technology Appraisal, PMID: 30547368

Randomized Phase II Trial Comparing Obinutuzumab (GA101) With Rituximab in Patients With Relapsed CD20+ Indolent B-Cell Non-Hodgkin Lymphoma: Final Analysis of the GAUSS Study, PMID: 26282650

Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy, PMID: 30341058

MRD response in relapsed/refractory FL after obinutuzumab plus bendamustine or bendamustine alone in the GADOLIN trial, PMID: 31462735

Obinutuzumab: what is there to learn from clinical trials?, PMID: 28584136

Obinutuzumab: A Review in Rituximab-Refractory or -Relapsed Follicular Lymphoma, PMID: 28324270

Phase II Study of Combination Obinutuzumab, Ibrutinib, and Venetoclax in Treatment-Naïve and Relapsed or Refractory Chronic Lymphocytic Leukemia, PMID: 32795224

A randomized, open-label, Phase III study of obinutuzumab or rituximab plus CHOP in patients with previously untreated diffuse large B-Cell lymphoma: final analysis of GOYA, PMID: 32505213

Obinutuzumab in hematologic malignancies: lessons learned to date, PMID: 26190254

Improving CD20 antibody therapy: obinutuzumab in lymphoproliferative disorders, PMID: 30668192

Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples, PMID: 28407142

Impact of obinutuzumab alone and in combination for follicular lymphoma, PMID: 31360086

Obinutuzumab for the treatment of chronic lymphocytic leukemia, PMID: 24983589

Successful Treatment of Patients With Refractory PLA 2 R-Associated Membranous Nephropathy With Obinutuzumab: A Report of 3 Cases, PMID: 32311405

Obinutuzumab-related adverse events: A systematic review and meta-analysis, PMID: 33252145

Obinutuzumab is Effective for the Treatment of Refractory Membranous Nephropathy, PMID: 32954076

Obinutuzumab: a new class of anti-CD20 monoclonal antibody, PMID: 25014645

Role of obinutuzumab in the treatment of chronic lymphocytic leukemia, PMID: 25987688

Obinutuzumab for the treatment of lymphoproliferative disorders, PMID: 22283718

The fading star of obinutuzumab-chlorambucil regimen in patients with comorbidities with chronic lymphocytic leukemia - are we ready for chemo-free immunotherapy approach?, PMID: 32579408

Combinability of epcoritamab CD20-targeting T-cell engager and CD20 antibody-targeted therapies in B-cell non-Hodgkin lymphoma., PMID:40528731

The anti-CD47 antibody magrolimab with obinutuzumab and venetoclax in relapsed or refractory indolent B-cell lymphomas., PMID:40524014

[Obinutuzumab in lupus nephritis: success with effective B cell depletion]., PMID:40522494

A Phase 2 Study of Obinutuzumab Combined with Lenalidomide in Previously Untreated High Tumor Burden Follicular Lymphoma., PMID:40517417

Beyond BCL2 (B cell lymphoma) and BTK (Bruton tyrosine kinase) inhibitors: novel agents and resistance mechanisms for chronic lymphocytic leukemia., PMID:40515863

Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance., PMID:40501414

Advances and challenges in leukemia treatment: A focus on monoclonal antibodies and emerging therapies., PMID:40486885

In active lupus nephritis, adding obinutuzumab to standard therapy increased complete renal response rates at 76 wk., PMID:40456159

Short-duration infusion obinutuzumab with venetoclax in chronic lymphocytic leukemia: a prospective observational study., PMID:40453137

Single-Agent and Associated Therapies with Monoclonal Antibodies: What About Follicular Lymphoma?, PMID:40427101

Obinutuzumab in Patients With Active Lupus Nephritis: A Meta-Analysis., PMID:40424616

Obinutuzumab-Induced Inflammatory Bowel Disease-Like Colitis., PMID:40421460

Cardiac Events in Three Phase 3 Randomized Trials Including Acalabrutinib in Chronic Lymphocytic Leukemia., PMID:40413154

Successful treatment of pemphigus vulgaris with obinutuzumab., PMID:40406957

Additive Obinutuzumab Achieves High Remission Rates in Rituximab-Refractory Membranous Nephropathy., PMID:40388905

Early caplacizumab and obinutuzumab enable successful treatment of relapsing thrombotic thrombocytopenic purpura without therapeutic plasma exchange: a case report., PMID:40356910

Phase II study of venetoclax added to bendamustine and obinutuzumab in patients with high-risk follicular lymphoma as front-line therapy: PrE0403., PMID:40355425

Clinical experience and safety of venetoclax in the treatment of patients with chronic lymphocytic leukemia - real-world data from a hemato-oncology center., PMID:40353625

Obinutuzumab as a Promising Treatment for Membranous Nephropathy., PMID:40352879

CRISPRi screening identifies PIKfyve as a co-therapeutic target for obinutuzumab., PMID:40342289

Obinutuzumab is effective for the treatment of rituximab-refractory PLA2R-associated membranous nephropathy., PMID:40336511

[Seronegativity and anti-CD20: When a treatment compromises the diagnosis]., PMID:40312237

Obinutuzumab for treatment of membranous nephropathy in patients positive and negative for the phospholipase A2 receptor antibody: case reports., PMID:40303416

Obinutuzumab in Rituximab-Intolerant Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients., PMID:40303206

Immunotherapy for autoimmune encephalitis., PMID:40301313

Atezolizumab, obinutuzumab and venetoclax for the treatment of patients with relapsed/refractory B non-Hodgkin lymphoma: Final analysis of a phase II trial from the LYSA group., PMID:40285420

Osteonecrosis of the Jaw Associated with Obinutuzumab in a Patient with Preceding Follicular Non-Hodgkin's Lymphoma., PMID:40278317

How we manage immune-mediated thrombotic thrombocytopenic purpura after rituximab failure or intolerance., PMID:40270461

Successful Treatment of Ocular Post-Transplant Lymphoproliferative Disorder with Obinutuzumab in an 8-Year-Old Boy Following Kidney Transplant: A Case Report., PMID:40255019

An autopsy for persistent coronavirus disease 2019 pneumonia during follicular lymphoma treatment: A case report., PMID:40254437

Clinical characteristics, treatment patterns and outcomes of patients with follicular lymphoma in Colombia: a real-world evidence cohort study., PMID:40227475

Obinutuzumab and Ofatumumab are More Effective Than Rituximab in the Treatment of Membranous Nephropathy Patients With Anti-Rituximab Antibodies., PMID:40225374

Obinutuzumab-induced Acute Thrombocytopenia Mimicking Immune Thrombocytopenia in a Patient with Follicular Lymphoma., PMID:40222942

Obinutuzumab in focal segmental glomerulonephritis resistant to treatment., PMID:40221341

AMPLIFY: A second-generation BTK inhibitor for fixed-duration therapy in chronic lymphocytic leukemia., PMID:40220751

B cell depletion in lupus nephritis: From disappointments to hopes, despite some concerns., PMID:40220749

A New Pulmonary Nodule in a Patient With a History of Lymphoma., PMID:40210319

Obinutuzumab: a new frontier in the treatment of refractory idiopathic membranous nephropathy., PMID:40205126

Acalabrutinib-Obinutuzumab Improves Survival vs Chemoimmunotherapy in treatment-naive CLL in the 6-year Follow-up of ELEVATE-TN., PMID:40198878

Obinutuzumab in patients with repeated lupus nephritis flares: A case series., PMID:40186329

Glofitamab in refractory or relapsed diffuse large B cell lymphoma after failing CAR-T cell therapy: a phase 2 LYSA study., PMID:40181090

A pilot study to determine the feasibility and safety of pharmacist and nurse driven management of venetoclax ramp-up in patients with chronic lymphocytic leukemia., PMID:40170466

Treatment of nephrotic syndrome with anti-CD20 therapies in pregnancy: a case series and review of the literature., PMID:40148078

Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody., PMID:40118783

Zanubrutinib, venetoclax, and obinutuzumab in R/R CLL., PMID:40111334

The role of obinutuzumab in rituximab-refractory membranous nephropathy and minimal change disease., PMID:40104551

Long-term outcomes of chemoimmunotherapy with obinutuzumab/chlorambucil in chronic lymphocytic leukemia., PMID:40101233

Erratum: Phase II Study of Acalabrutinib, Venetoclax, and Obinutuzumab in a Treatment-Naïve Chronic Lymphocytic Leukemia Population Enriched for High-Risk Disease., PMID:40101168

Upfront fixed-duration treatment strategies for chronic lymphocytic leukemia in Arab populations: a position statement from the Gulf region., PMID:40078401

Real-World Effectiveness of Frontline Treatments Among Patients with Chronic Lymphocytic Leukemia: Results from ConcertAI., PMID:40075647

Datasheet

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Research Grade Obinutuzumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Obinutuzumab [DHC90704]
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