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Research Grade Bavituximab

Catalog #:   DGK10101 Specific References (82) DATASHEET
Host species: Chimeric
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DGK10101

Expression system

Mammalian Cells

Species reactivity

General

Host species

Chimeric

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Phosphatidylserine

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

CAS: 1446756-47-3

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Tarvacin ch3G4, CAS: 648904-28-3

Clone ID

Bavituximab

Data Image
  • SDS-PAGE
    SDS PAGE for Bavituximab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Profile of bavituximab and its potential in the treatment of non-small-cell lung cancer, PMID: 28210141

Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment, PMID: 21843081

Phosphatidylserine: A cancer cell targeting biomarker, PMID: 28870843

Phase Ib Study of Bavituximab With Carboplatin and Pemetrexed in Chemotherapy-Naive Advanced Nonsquamous Non-Small-Cell Lung Cancer, PMID: 29631965

Docetaxel Combined With Bavituximab in Previously Treated, Advanced Nonsquamous Non-Small-Cell Lung Cancer, PMID: 27265742

Efficacy and Safety of Bavituximab in Combination with Sorafenib in Advanced Hepatocellular Carcinoma: A Single-Arm, Open-Label, Phase II Clinical Trial, PMID: 31429027

Randomized phase III study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer, PMID: 29767677

Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer, PMID: 25236982

A Phase I Clinical Trial of the Phosphatidylserine-targeting Antibody Bavituximab in Combination With Radiation Therapy and Capecitabine in the Preoperative Treatment of Rectal Adenocarcinoma, PMID: 28763330

Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts, PMID: 26550540

A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer, PMID: 25826750

Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors, PMID: 21989064

Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases, PMID: 19029986

Targeting phosphatidylserine for Cancer therapy: prospects and challenges, PMID: 32802188

[ 74 As]-Labeled monoclonal antibody against anionic phospholipids, PMID: 20641667

Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis, PMID: 31910414

Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine, PMID: 18316558

Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts, PMID: 26847681

Antibodies to watch in 2014: mid-year update, PMID: 24846335

Hepatitis C therapy: other players in the game, PMID: 21867942

Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer, PMID: 29417044

Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma, PMID: 19887482

Gateways to clinical trials, PMID: 20140276

Antibodies to watch in 2016, PMID: 26651519

Gateways to clinical trials, PMID: 19088949

Effective binding of a phosphatidylserine-targeting antibody to Ebola virus infected cells and purified virions, PMID: 25815346

Click-chemistry strategy for labeling antibodies with copper-64 via a cross-bridged tetraazamacrocyclic chelator scaffold, PMID: 25760776

Generation and tumor recognition properties of two human monoclonal antibodies specific to cell surface anionic phospholipids, PMID: 25983040

Protective Effect of Anti-Phosphatidylserine Antibody in a Guinea Pig Model of Advanced Hemorrhagic Arenavirus Infection, PMID: 29290843

An orthotopic lung tumor model for image-guided microirradiation in rats, PMID: 20681800

Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells, PMID: 18570887

Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody, PMID: 23165089

Novel agents and future prospects in the treatment of pancreatic adenocarcinoma, PMID: 23846936

Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation, PMID: 24777853

Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids, PMID: 17785577

Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor, PMID: 26391350

Targeting anionic phospholipids on tumor blood vessels and tumor cells, PMID: 20433993

Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production, PMID: 34215655

Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications., PMID:39896467

Expression, purification and characterization of phosphatidylserine-targeting antibodies for biochemical and therapeutic applications., PMID:39824554

Development of betabodies: The next generation of phosphatidylserine targeting agents., PMID:39159812

The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial., PMID:38467639

Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients., PMID:37327319

Phosphatidylserine: The Unique Dual-Role Biomarker for Cancer Imaging and Therapy., PMID:35626139

A Phase 2 Clinical Trial of the Phosphatidylserine-Targeting Antibody Bavituximab in Combination With Pembrolizumab in Patients With Advanced Hepatocellular Carcinoma., PMID:35611264

Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production., PMID:34215655

Targeting phosphatidylserine for Cancer therapy: prospects and challenges., PMID:32802188

Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis., PMID:31910414

Efficacy and Safety of Bavituximab in Combination with Sorafenib in Advanced Hepatocellular Carcinoma: A Single-Arm, Open-Label, Phase II Clinical Trial., PMID:31429027

Randomized phase III study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer., PMID:29767677

Phase Ib Study of Bavituximab With Carboplatin and Pemetrexed in Chemotherapy-Naive Advanced Nonsquamous Non-Small-Cell Lung Cancer., PMID:29631965

Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer., PMID:29417044

Protective Effect of Anti-Phosphatidylserine Antibody in a Guinea Pig Model of Advanced Hemorrhagic Arenavirus Infection., PMID:29290843

Phosphatidylserine: A cancer cell targeting biomarker., PMID:28870843

A Phase I Clinical Trial of the Phosphatidylserine-targeting Antibody Bavituximab in Combination With Radiation Therapy and Capecitabine in the Preoperative Treatment of Rectal Adenocarcinoma., PMID:28763330

Docetaxel Combined With Bavituximab in Previously Treated, Advanced Nonsquamous Non-Small-Cell Lung Cancer., PMID:27265742

Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts., PMID:26847681

Antibodies to watch in 2016., PMID:26651519

Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts., PMID:26550540

Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor., PMID:26391350

Generation and tumor recognition properties of two human monoclonal antibodies specific to cell surface anionic phospholipids., PMID:25983040

A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer., PMID:25826750

Effective binding of a phosphatidylserine-targeting antibody to Ebola virus infected cells and purified virions., PMID:25815346

Click-chemistry strategy for labeling antibodies with copper-64 via a cross-bridged tetraazamacrocyclic chelator scaffold., PMID:25760776

Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer., PMID:25236982

Profile of bavituximab and its potential in the treatment of non-small-cell lung cancer., PMID:28210141

Antibodies to watch in 2014: mid-year update., PMID:24846335

Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation., PMID:24777853

Novel agents and future prospects in the treatment of pancreatic adenocarcinoma., PMID:23846936

Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody., PMID:23165089

Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors., PMID:21989064

Hepatitis C therapy: other players in the game., PMID:21867942

Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment., PMID:21843081

An orthotopic lung tumor model for image-guided microirradiation in rats., PMID:20681800

Targeting anionic phospholipids on tumor blood vessels and tumor cells., PMID:20433993

Gateways to clinical trials., PMID:20140276

Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma., PMID:19887482

Gateways to clinical trials., PMID:19088949

Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases., PMID:19029986

Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells., PMID:18570887

Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine., PMID:18316558

Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids., PMID:17785577

Datasheet

Document Download

Research Grade Bavituximab.pdf

 

$ 372
Product specifications
100 μg 372 1 mg 1486

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Research Grade Bavituximab [DGK10101]
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