Catalog No.
YHG15801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His568-Phe829
Predicted molecular weight
31.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08345
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, EDDR1, CAK, Tyrosine kinase DDR, Mammary carcinoma kinase 10, TRKE, Epithelial discoidin domain-containing receptor 1, CD167a, TRK E, Epithelial discoidin domain receptor 1, HGK2, CD167 antigen-like family member A, NEP, MCK-10, Tyrosine-protein kinase CAK, PTK3A, DDR1, Discoidin receptor tyrosine kinase, RTK6, Cell adhesion kinase
The Overexpression of Collagen Receptor DDR1 is Associated With Chromosome Instability and Aneuploidy in Diffuse Large B-Cell Lymphoma., PMID:40401507
Targeted degradation of DDR1 by proteolytic targeting chimera reverses immune exclusion for tumor immunotherapy., PMID:40382838
DCAF8L1 induces branching morphogenesis and hollow acinar structures remodeling of MCF10A cells in 3D culture by upregulating DDR1., PMID:40239542
DDR1 Targeting HOXA6 Facilitates Bladder Cancer Progression via Inhibiting Ferroptosis., PMID:40105492
Stiffness regulates extracellular matrix synthesis in fibroblasts by DDR1-TGF-β/STAT3 mechanotransduction axis., PMID:40023083
Identification of DDR1 Inhibitors from Marine Compound Library Based on Pharmacophore Model and Scaffold Hopping., PMID:39940867
Loss-of-function of DDR1 is responsible for a chondrodysplasia with multiple dislocations., PMID:39714220
DDR1 in pancreatic adenocarcinoma: unraveling the mechanisms of immune exclusion., PMID:39713856
The role of DDR1 in cancer and the progress of its selective inhibitors., PMID:39642752
Inhibition of discoidin domain receptor 1 as a new therapeutic strategy for osteosarcoma., PMID:39641588
TFAP2C-DDR1 axis regulates resistance to CDK4/6 inhibitor in breast cancer., PMID:39603379
Role of DDR1 in Regulating MMPs in External Root Resorption., PMID:39596178
DDR1 promotes metastasis of cervical cancer and downstream phosphorylation signal via binding GRB2., PMID:39567474
[MiR-6838-5p overexpression inhibits proliferation of breast cancer MCF-7 cells by downregulating DDR1 expression]., PMID:39505335
Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis., PMID:39485950
Super-resolution imaging reveals the role of DDR1 cluster in NSCLC proliferation., PMID:39406104
The major vault protein integrates adhesion-driven signals to regulate collagen remodeling., PMID:39368789
DDR1 is a Novel Biomarker and Potential Therapeutic Target for the Combination Treatment of Liver Hepatocellular Carcinoma., PMID:39284684
Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in Association with Myelination and Remyelination Process in the Central Nerve System., PMID:39175192
Inhibition of DDR1 promotes ferroptosis and overcomes gefitinib resistance in non-small cell lung cancer., PMID:39089636
Antibody-drug conjugates targeting DDR1 as a novel strategy for treatment of breast cancer., PMID:39072640
DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF-1α Ubiquitination and Degradation., PMID:39024501
From pixels to druggable leads: A CADD strategy for the design and synthesis of potent DDR1 inhibitors., PMID:38991374
Overcoming the Tumor Collagen Barriers: A Multistage Drug Delivery Strategy for DDR1-Mediated Resistant Colorectal Cancer Therapy., PMID:38953306
Discovery of a prominent dual-target DDR1/EGFR inhibitor aimed DDR1/EGFR-positive NSCLC., PMID:38823310
Discovery of LLC355 as an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1., PMID:38730324
DDR1-targeted therapies: current limitations and future potential., PMID:38580164
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1., PMID:38570692
Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients., PMID:38503928
Research progress of DDR1 inhibitors in the treatment of multiple human diseases., PMID:38452728
Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder., PMID:38395959
Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms., PMID:38374360
Evaluation of t-DARPP Expression Alteration in Association with DDR1 Expression in Non-Small Cell Lung Cancer., PMID:38308500
Blockade of DDR1/PYK2/ERK signaling suggesting SH2 superbinder as a novel autophagy inhibitor for pancreatic cancer., PMID:38071340
Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study., PMID:37768856
Clinical significance of immunohistochemical expression of DDR1 and β-catenin in colorectal carcinoma., PMID:37271822
Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer., PMID:37201403
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression., PMID:37117273
A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance., PMID:37031216
DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development., PMID:36809965
DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation., PMID:36675255
Cross-sectional and longitudinal assessment of the association between DDR1 variants and processing speed in patients with early psychosis and healthy controls., PMID:36571911
Chlorogenic acid regulates the proliferation and migration of high-grade serous ovarian cancer cells through modulating the miR199a5p/DDR1 axis., PMID:36508480
New target DDR1: A "double-edged sword" in solid tumors., PMID:36356724
DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18., PMID:35969377
DDR1 Deficiency in Mice: A Spontaneous Model of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension?, PMID:35969163
Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells., PMID:35957513
Discoidin domain receptor 1 is a potential target correlated with tumor invasion and immune infiltration in gastric cancer., PMID:35935941
Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis., PMID:35905891
DDR1 promotes migration and invasion of breast cancer by modulating the Src-FAK signaling., PMID:35818965
For research use only. Not for human or drug use.
