Catalog No.
YHG15701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu87-Ala243
Predicted molecular weight
20.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08334
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL10RB, IL-10 receptor subunit beta, CDw210b, IL-10R subunit beta, Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, IL-10R subunit 2, CRF2-4, D21S58, IL-10R2, D21S66, Cytokine receptor class-II member 4, Interleukin-10 receptor subunit beta, CRFB4, IL-10RB
Successful Use of Anakinra in a Patient with IL-10R Beta Deficiency: A Case Report., PMID:39950990
Matched Unrelated Donor Hematopoietic Stem Cell Transplant as Successful Curative Therapy for IL10RB Mutation-Associated Very Early Onset IBD., PMID:39539152
A Heuristic Approach to Analysis of the Genetic Susceptibility Profile in Patients Affected by Airway Allergies., PMID:39202464
In search of a function for human type III interferons: insights from inherited and acquired deficits., PMID:38781720
Tumour-associated myeloid cells expressing IL-10R2/IL-22R1 as a potential biomarker for diagnosis and recurrence of pancreatic ductal adenocarcinoma., PMID:38643339
A novel biallelic 19-bp deletion in the IL10RB gene caused infant-onset inflammatory bowel disease in a consanguineous family: a molecular docking simulation study and literature review., PMID:38281300
Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE., PMID:37511050
Clinical and cellular phenotypes resulting from a founder mutation in IL10RB., PMID:37503744
Altered Expression of the HLA-G and IL10RB Genes in Placental Tissue of Women with Recurrent Pregnancy Loss., PMID:37145066
Whole-genome sequencing reveals host factors underlying critical COVID-19., PMID:35255492
Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students., PMID:35205336
Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19., PMID:33949668
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19., PMID:33837377
Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling., PMID:33806448
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity., PMID:33633408
A bioinformatic approach to investigating cytokine genes and their receptor variants in relation to COVID-19 progression., PMID:33246355
Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier., PMID:32637365
Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130., PMID:32611765
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer., PMID:32430479
The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype., PMID:31948053
Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2., PMID:31819956
IL-22 suppresses HSV-2 replication in human cervical epithelial cells., PMID:31344598
[Clinical and genotypic characteristics of infantile inflammatory bowel disease]., PMID:31269551
Candidiasis associated with very early onset inflammatory bowel disease: First IL10RB deficient case from the National Iranian Registry and review of the literature., PMID:31096038
Association of a PD-L2 Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort., PMID:30594267
Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds., PMID:30365510
IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex., PMID:30247785
Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells., PMID:30217896
Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea., PMID:29992456
Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study., PMID:28982901
Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease., PMID:28785144
Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey., PMID:28267044
Investigation of Genetic Defects in Severe Combined Immunodeficiency Patients from Turkey by Targeted Sequencing., PMID:28109013
Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features., PMID:27665382
Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin's Lymphoma Risk and Survival., PMID:26448050
Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children., PMID:26329766
Exploring the role of interleukin-22 in neurological and autoimmune disorders., PMID:26311525
IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis., PMID:26130064
[Interleukin-10 receptor mutations in children with neonatal onset inflammatory bowel disease: genetic diagnosis and pathogenesis]., PMID:26080664
Identification of a 6-cytokine prognostic signature in patients with primary glioblastoma harboring M2 microglia/macrophage phenotype relevance., PMID:25978454
Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction., PMID:25955408
Interferon-λ-related genes and therapeutic response in Chinese hepatitis C patients., PMID:25852288
Monogenic autoinflammatory diseases: Cytokinopathies., PMID:25814341
IL22/IL-22R pathway induces cell survival in human glioblastoma cells., PMID:25793261
Clinical features of interleukin 10 receptor gene mutations in children with very early-onset inflammatory bowel disease., PMID:25373860
Extreme PCR: efficient and specific DNA amplification in 15-60 seconds., PMID:25320377
Suppression of hepatocellular carcinoma proliferation and hepatitis B surface antigen secretion with interferon-λ1 or PEG-interferon-λ1., PMID:24769671
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis., PMID:24379584
Reduced PMA enhances the responsiveness of transfected THP-1 macrophages to polarizing stimuli., PMID:24269601
Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group., PMID:24216686
For research use only. Not for human or drug use.
