Catalog No.
YHD87301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp162-Tyr416
Predicted molecular weight
31.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30101
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Disulfide isomerase ER-60, ER protein 60, ERp60, Endoplasmic reticulum resident protein 57, ERp57, ERP60, p58, Protein disulfide-isomerase A3, ER protein 57, ERP57, PDIA3, Endoplasmic reticulum resident protein 60, GRP58, 58 kDa glucose-regulated protein, 58 kDa microsomal protein
Targeting CALR reduces energy metabolism of esophageal cancer cells and inhibits tumor‑associated fibroblast infiltration., PMID:40417915
Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1α-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes., PMID:40403760
Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis., PMID:40371728
Expression of protein disulfide isomerase A3Q481K variant associated with amyotrophic lateral sclerosis triggers disease features in mice., PMID:40345258
Deleterious KOs in the HLA Class I Antigen Processing and Presentation Machinery Induce Distinct Changes in the Immunopeptidome., PMID:40113210
Exploring druggable targets and inflammation-mediated pathways in cancer: a Mendelian randomization analysis integrating transcriptomic and proteomic data., PMID:40038097
Alterations in ether phospholipids metabolism activate the conserved UPR-Xbp1- PDIA3/ERp60 signaling to maintain intestinal homeostasis., PMID:40034858
Pdia3 deficiency exacerbates intestinal injury by disrupting goblet and Paneth cell function during ischemia/reperfusion., PMID:39988288
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
The NLRP3 activation-related signature predicts the diagnosis and indicates immune characteristics in endometriosis., PMID:39904070
A cellular model of TDP-43 induces phosphorylated TDP-43 aggregation with distinct changes in solubility and autophagy dysregulation., PMID:39887552
Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women., PMID:39702372
PDIA3 rs2788: An Independent Risk Factor for Hypertension and Its Interaction With Antihypertensive Medications., PMID:39686834
Association Between Peptide Antigen-Related Antibody Levels and the Short- and Long-Term Efficacy of Antipsychotic Treatment in Drug-Naïve First-Episode Schizophrenia Patients., PMID:39673496
Protein disulfide isomerase 1 (PDIA1) regulates platelet-derived extracellular vesicle release., PMID:39566352
Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese., PMID:39566171
Analysis of Punicalin and Punicalagin Interaction with PDIA3 and PDIA1., PMID:39408858
Erp57 facilitates ZIKV-induced DNA damage via NS2B/NS3 complex formation., PMID:39404735
Effects of treadmill exercise on endoplasmic reticulum protein folding and endoplasmic reticulum-associated protein degradation pathways in APP/PS1 mice., PMID:39397952
Reticulophagy and viral infection., PMID:39394962
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders., PMID:39293433
G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner., PMID:39289547
The PDIA3-STAT3 protein complex regulates IBS formation and development via CTSS/MHC-II pathway-mediated intestinal inflammation., PMID:39286134
Investigation of endoplasmic reticulum stress-regulated chaperones as biomarkers in idiopathic nonobstructive azoospermia., PMID:39237030
Suppressing ERp57 diminishes osteoclast activity and ameliorates ovariectomy-induced bone loss via the intervention in calcium oscillation and the calmodulin/calcineurin/Nfatc1 pathway., PMID:39170388
Therapeutic Options of Crystallin Mu and Protein Disulfide Isomerase A3 for Cuprizone-Induced Demyelination in Mouse Hippocampus., PMID:39164609
Single-cell analysis identified PDIA3 as regulator of malignant characteristics and macrophage function in human cancers., PMID:39138692
AP3B1 facilitates PDIA3/ERP57 function to regulate rabies virus glycoprotein selective degradation and viral entry., PMID:39128851
The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling., PMID:39118388
Epididymal mRNA expression profiles for the protein disulfide isomerase gene family: Modulation by development and androgens., PMID:39087751
Redox Enzymes P4HB and PDIA3 Interact with STIM1 to Fine-Tune Its Calcium Sensitivity and Activation., PMID:39062821
Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin., PMID:38964787
CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer., PMID:38861804
Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells., PMID:38861223
Endoplasmic reticulum protein of 57 kDa sulfhydration promotes intestinal calcium absorption to attenuate primary osteoporosis., PMID:38830571
PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2., PMID:38822524
Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma., PMID:38800530
Inclusive Pattern Generation Protocols to Decode Thiol-Mediated Uptake., PMID:38799667
Effects of alcohol consumption and tobacco smoking on the composition of the ensemble of drug metabolizing enzymes and transporters in human liver., PMID:38798409
Dual role of the peptide-loading complex as proofreader and limiter of MHC-I presentation., PMID:38771881
PDIA3 driven STAT3/PD-1 signaling promotes M2 TAM polarization and aggravates colorectal cancer progression., PMID:38761176
Protein disulfide isomerase A1 regulates fenestration dynamics in primary mouse liver sinusoidal endothelial cells (LSECs)., PMID:38669864
Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release., PMID:38548704
Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p., PMID:38464366
Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): Effects on proliferation, migration, and genes in control of active vitamin D., PMID:38460707
Inducing Melanoma Cell Apoptosis by ERp57/PDIA3 Antibody in the Presence of CPI-613 and Hydroxychloroquine., PMID:38434963
Downregulation of PDIA3 inhibits gastric cancer cell growth through cell cycle regulation., PMID:38412717
A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis., PMID:38321831
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels., PMID:38320121
The role of PDIA3 in oral squamous cell carcinoma and its value as A diagnostic and prognostic biomarker., PMID:38213579
For research use only. Not for human or drug use.
