Catalog No.
YHD80301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr18-Asp363
Predicted molecular weight
39.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28799
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B
Exploring Birch Salt Tolerance Using Gene Regulatory Network Highlighting Hormone Signaling, Reactive Oxygen Species Scavenging, and Ion Homeostasis., PMID:40511624
Dynamic control of Argonautes by a rapidly evolving immunological switch., PMID:40494360
Regulatory feedback between VEGF and ERK pathways controls tip-cell expression during sea urchin skeletogenesis., PMID:40492925
Topological isomers of a potent wound healing peptide: structural insights and implications for bioactivity., PMID:40480634
Analysis of the splicing landscape of the frontal cortex in FTLD-TDP reveals subtype specific patterns and cryptic splicing., PMID:40478310
Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia., PMID:40476255
HarmGR13 mediates myo-inositol taste perception in Helicoverpa armigera larvae., PMID:40460174
PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases., PMID:40456955
Therapeutic targets for Alzheimer's disease: Proteome-wide Mendelian randomization and colocalization analyses., PMID:40452368
Chondrocyte maturation bridges two cross-inhibitory subnetworks of the skeletal cell gene regulatory network., PMID:40440101
The antioxidant stress effect of granulin precursor in vitiligo., PMID:40415096
Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease., PMID:40414310
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay., PMID:40401628
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration., PMID:40380000
Model-to-crop conserved NUE Regulons enhance machine learning predictions of nitrogen use efficiency., PMID:40365911
Identification of the Plant Defensin (MsPDF) Gene Family in Medicago sativa and Analysis of Expression Patterns Under Abiotic Stress., PMID:40364341
The Intersection of Genetics and Neuroimaging: A Systematic Review of Imaging Genetics in Neurological Disease for Personalized Treatment., PMID:40360788
ANXA11 Mutations in the FTD Spectrum: A Novel Finding in a Patient With Semantic Variant Primary Progressive Aphasia., PMID:40345169
Neuronal ceroid lipofuscinosis type 11 in early childhood., PMID:40316283
LATE-NC Stage 3: a diagnostic rubric to differentiate severe LATE-NC from FTLD-TDP., PMID:40293530
Molecular mechanisms and targeted therapy of progranulin in metabolic diseases., PMID:40290306
Development of novel prognostic protein signatures in ovarian cancer: Molecular structure and immune function of AQP5 protein and CTDP1 protein., PMID:40286746
Sex differences in the executive and behavioral reserve of autosomal dominant frontotemporal dementia., PMID:40277045
Randomization based evaluation of distinct topological and cancer expression characteristics of mutually acting gene pairs., PMID:40257012
Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype., PMID:40236025
Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells., PMID:40234992
A role for astrocytic miR-129-5p in frontotemporal dementia., PMID:40216778
The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins., PMID:40212812
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses., PMID:40200337
Unraveling cadmium tolerance mechanisms in Betula platyphylla through a hierarchical gene regulatory network in hormone signaling., PMID:40188532
Uncovering leading compounds for alzheimer's disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation., PMID:40186323
Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson's disease., PMID:40184012
Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection., PMID:40180225
Single-cell sequencing uncovers a high ESM1-expression endothelial cell subpopulation associated with bladder cancer progression and the immunosuppressive microenvironment., PMID:40159545
PGRN knockdown alleviates pulmonary fibrosis regulating the Akt/GSK3β signaling pathway., PMID:40088870
Single-cell multiomic comparison of mouse and rat spermatogenesis reveals gene regulatory networks conserved for over 20 million years., PMID:40086448
Macrophage-Specific Progranulin Deficiency Prevents Diet-Induced Obesity through the Inhibition of Hypothalamic and Adipose Tissue Inflammation., PMID:40068621
A novel c.1468 G > A GRN mutation causes frontotemporal dementia in a Chinese Han family., PMID:40055834
Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanisms., PMID:40055725
Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data., PMID:40050982
A pathogenic subpopulation of human glioma associated macrophages linked to glioma progression., PMID:40027797
A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy., PMID:40020677
Variability in proliferative and migratory defects in Hirschsprung disease-associated RET pathogenic variants., PMID:40010351
Integrated multiomics analysis highlights the immunosuppressive role of granulin precursor positive macrophages in hepatocellular carcinoma., PMID:39995994
Evaluating sample normalization methods for MS-based multi-omics and the application to a neurodegenerative mouse model., PMID:39995368
DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci., PMID:39975316
Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei., PMID:39962601
Montreal Cognitive Assessment vs the Mini-Mental State Examination as a Screening Tool for Patients With Genetic Frontotemporal Dementia., PMID:39951678
Single-Cell Analysis Dissects the Effects of Vitamin D on Genetic Senescence Signatures Across Murine Tissues., PMID:39940287
For research use only. Not for human or drug use.
