Catalog No.
YHJ98201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr180-Val479
Predicted molecular weight
37.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BRS2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RIO kinase 1, Serine/threonine-protein kinase RIO1, RIOK1, RIO1
Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery., PMID:40502754
RIOK1: A Novel Oncogenic Driver in Hepatocellular Carcinoma., PMID:39865406
Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5., PMID:39793893
Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer., PMID:39488790
Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks., PMID:38730267
A role for RIO kinases in the crosshair of cancer research and therapy., PMID:38604268
A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer., PMID:38391955
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency., PMID:38324746
The RioK1 network determines p53 activity at multiple levels., PMID:37935656
The Oncogenic Protein Kinase/ATPase RIOK1 Is Up-Regulated via the c-myc/E2F Transcription Factor Axis in Prostate Cancer., PMID:37301535
Riok1, A Novel Potential Target in MSI-High p53 Mutant Colorectal Cancer Cells., PMID:37298928
Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores., PMID:37263996
DKK3's protective role in prostate cancer is partly due to the modulation of immune-related pathways., PMID:36845147
Yellow catfish RIO kinases (RIOKs) negatively regulate fish interferon-mediated antiviral response., PMID:36746265
Chronic exposure to di(2-ethylhexyl) phthalate (DEHP) weakens innate immunity and leads to immunosenescence in C. elegans., PMID:36690191
Taming PRMT5-adaptor protein interactions., PMID:36669975
Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors., PMID:36378254
NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex., PMID:36040368
RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2., PMID:35589951
RIOK1 is associated with non-small cell lung cancer clinical characters and contributes to cancer progression., PMID:35281872
Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma., PMID:34475988
MTAP Deficiency-Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer., PMID:34385182
Molecular basis for substrate recruitment to the PRMT5 methylosome., PMID:34358446
First Evidence of Function for Schistosoma japonicumriok-1 and RIOK-1., PMID:34358012
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction., PMID:34342224
The final step of 40S ribosomal subunit maturation is controlled by a dual key lock., PMID:33908345
Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex., PMID:33624332
Structural basis for the final steps of human 40S ribosome maturation., PMID:33208940
Glutathionylation Decreases Methyltransferase Activity of PRMT5 and Inhibits Cell Proliferation., PMID:32868396
Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression., PMID:32634130
Elevated Expression of RIOK1 Is Correlated with Breast Cancer Hormone Receptor Status and Promotes Cancer Progression., PMID:32599985
USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit., PMID:32129764
Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology., PMID:31206508
Crystal structure of human RIOK2 bound to a specific inhibitor., PMID:30991936
The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stability., PMID:30515528
LKB1 regulates PRMT5 activity in breast cancer., PMID:30289978
Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA., PMID:30224484
Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae., PMID:30011030
Genome-wide identification and characterization of the RIO atypical kinase family in plants., PMID:29892951
Visualizing late states of human 40S ribosomal subunit maturation., PMID:29875412
RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway in Caenorhabditis elegans., PMID:29719537
Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers., PMID:29384474
The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway., PMID:29233656
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma., PMID:28966034
Functional genomic exploration reveals that Ss-RIOK-1 is essential for the development and survival of Strongyloides stercoralis larvae., PMID:28780152
The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior., PMID:28499923
Benzimidazole inhibitors of protein kinase CK2 potently inhibit the activity of atypical protein kinase Rio1., PMID:27909846
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis., PMID:27068473
Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation., PMID:26310847
Flatworms have lost the right open reading frame kinase 3 gene during evolution., PMID:25976756
For research use only. Not for human or drug use.
