Catalog No.
YHJ97001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn156
Predicted molecular weight
20.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y281
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CFL2, Cofilin-2, Cofilin, muscle isoform
Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach., PMID:40419934
Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis., PMID:40343003
The Impact Of Modern Industrialized Dietary Sodium Intake On The Plasma Proteome., PMID:40327765
A high affinity Sybody blocks Cofilin-1 binding to F-actin in vitro and in cancer cells., PMID:40064451
Neonatal Encephalopathy: Novel Phenotypes and Genotypes Identified by Genome Sequencing., PMID:39810752
Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit Cofilin-2-Induced Thin Filament Depolymerization., PMID:38003645
Integrated Network Analysis of microRNAs, mRNAs, and Proteins Reveals the Regulatory Interaction between hsa-mir-200b and CFL2 Associated with Advanced Stage and Poor Prognosis in Patients with Intestinal Gastric Cancer., PMID:38001634
Comprehensive analysis of lncRNA-miRNA-mRNA ceRNA network and key genes in granulosa cells of patients with biochemical primary ovarian insufficiency., PMID:37847421
Proteome-Wide Mendelian Randomization Analysis Identified Potential Drug Targets for Atrial Fibrillation., PMID:37581400
Identification cloning and functional analysis of novel natural antisense lncRNA CFL1-AS1 in cattle., PMID:37406176
Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome., PMID:37212950
Performance efficient macromolecular mechanics via sub-nanometer shape based coarse graining., PMID:37037809
Cannabichromene Induces Neuronal Differentiation in NSC-34 Cells: Insights from Transcriptomic Analysis., PMID:36983897
LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis., PMID:36450139
Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma., PMID:36291816
Mercury metalloproteomic profile in muscle tissue of Arapaima gigas from the Brazilian Amazon., PMID:35999477
Is the small heat shock protein HSPB7 (cvHsp) a genuine actin-binding protein?, PMID:35977674
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and in Vivo., PMID:35976233
Investigating the Paracrine Role of Perinatal Derivatives: Human Amniotic Fluid Stem Cell-Extracellular Vesicles Show Promising Transient Potential for Cardiomyocyte Renewal., PMID:35757808
Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode., PMID:35440100
MiR-320-3p Regulates the Proliferation and Differentiation of Myogenic Progenitor Cells by Modulating Actin Remodeling., PMID:35054986
Identification of Serum Biomarkers in Patients with Alzheimer's Disease by 2D-DIGE Proteomics., PMID:35021178
MiR-141-3p regulates myogenic differentiation in C2C12 myoblasts via CFL2-YAP-mediated mechanotransduction., PMID:35000671
Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis., PMID:34903141
Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization., PMID:34869336
Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration., PMID:34685706
Role of MiR-325-3p in the Regulation of CFL2 and Myogenic Differentiation of C2C12 Myoblasts., PMID:34685705
Palmitic Acid-Induced miR-429-3p Impairs Myoblast Differentiation by Downregulating CFL2., PMID:34681631
Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer's Disease in Amyloid Precursor Protein/Presenilin 1 Mice., PMID:34658785
A review of core myopathy: central core disease, multiminicore disease, dusty core disease, and core-rod myopathy., PMID:34627702
Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis., PMID:34324029
Prognostic Significance of Cofilin Isoforms in Patients With Pancreatic Ductal Adenocarcinoma., PMID:34257623
Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia., PMID:34235487
Curled Flag Leaf 2, Encoding a Cytochrome P450 Protein, Regulated by the Transcription Factor Roc5, Influences Flag Leaf Development in Rice., PMID:33643332
Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling., PMID:33442268
Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation., PMID:33412494
The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics., PMID:33339131
CFL2 is an essential mediator for myogenic differentiation in C2C12 myoblasts., PMID:33187645
Teratogenesis in the chick embryo following post-gastrulation exposure to Y-27632 -effect of Y-27632 on embryonic development., PMID:33049266
Electrochemical data on redox properties of human Cofilin-2 and its Mutant S3D., PMID:33024804
Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE Proteomics., PMID:32973486
Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation., PMID:32863228
miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function., PMID:32824678
Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth., PMID:32697999
Regulation of Actin Filament Length by Muscle Isoforms of Tropomyosin and Cofilin., PMID:32560136
Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction., PMID:32390525
Mutational and clinical spectrum in a cohort of Chinese patients with hereditary nemaline myopathy., PMID:32222963
Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype., PMID:32160286
Flow-enhanced priming of hESCs through H2B acetylation and chromatin decondensation., PMID:31775893
A novel protein L-cofilin2 identified in Lampetra morii with roles of immune response and cell proliferation promotion., PMID:31774909
For research use only. Not for human or drug use.
