Catalog No.
EHJ93501
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
[Arg23-Ser219] & [Arg21-Lys229]
Predicted molecular weight
74.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P29459 & Q14213
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-35, IL35, IL-35
Pro-Resolving Macrophage-Induced IL-35+ but Not TGF-β1+ Regulatory B Cell Activation Requires the PD-L1/PD-1 Pathway., PMID:40508140
Altered Serum IL-35 Levels and IL-37 Gene Expression in Patients with Parkinson's Disease: Focus on Emerging Cytokines., PMID:40483561
The distinct role of IL-34 and IL-35 in gastric cancer., PMID:40416985
IL-35 Ameliorates Myocardial Strain in Mice with T2DM-Induced Cardiac Injury: Assessment by Layer-Specific Strain., PMID:40375942
Low IL-35 expression in CSF is associated with Neuro-Behcet Disease: Comparative analysis between parenchymal and Non-parenchymal NBD., PMID:40360083
Neuroinflammation and Amyotrophic Lateral Sclerosis: Recent Advances in Anti-Inflammatory Cytokines as Therapeutic Strategies., PMID:40332510
Genetic variant rs2243115 of the IL-12/IL-35 pathway contributes to the risk of coronary artery disease., PMID:40303485
Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis., PMID:40288071
Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35., PMID:40274281
High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis., PMID:40264784
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway., PMID:40259042
Cytokine Expression and Cytolytic Effect of Natural Killer Cells are Suppressed in Septic Shock., PMID:40254928
Lidocaine Modulates Cytokine Production and Reprograms the Tumor Immune Microenvironment to Enhance Anti-Tumor Immune Responses in Gastric Cancer., PMID:40244064
Role of serum IL-35 levels in patients with benign and malignant primary ovarian tumors: a case-control study., PMID:40229348
Increased Peripheral Interleukin-35 Suppresses CD4+ T and CD8+ T-Cell Activity in Patients Living with Chronic Human Immunodeficiency Virus-1 Infection., PMID:40131183
IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases., PMID:40114923
Interleukin-35 inhibits NETs to ameliorate Th17/Treg immune imbalance during the exacerbation of cigarette smoke exposed-asthma via gp130/STAT3/ferroptosis axis., PMID:40101533
Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins., PMID:40093899
Investigating the expression of anti/pro-inflammatory cytokines in the pathogenesis and treatment of ulcerative colitis and its association with serum level of vitamin D., PMID:40038357
IL35 modulates HBV-related HCC progression via IL6-STAT3 signaling., PMID:39984567
Systematic Review of Interleukin-35 in Endothelial Dysfunction: A New Target for Therapeutic Intervention., PMID:39974277
Interleukin-35 mRNA therapy for influenza virus-induced pneumonia in mice., PMID:39947345
Effect of non-surgical periodontal therapy on the salivary levels of IL-18 and IL-35 in patients with periodontitis., PMID:39886869
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis., PMID:39825933
Role of IFN-γ, IL-33, and IL-35 concentrations in tuberculous pleural effusion in diagnosis and analysis of the effectiveness of combined tests., PMID:39809152
Plasma Interleukin-35 Levels Predict the Prognosis in Patients with HBV-Related Acute-on-Chronic Liver Failure., PMID:39772266
Abnormalities of IL-12 Family Cytokine Pathways in Autosomal Dominant Polycystic Kidney Disease Progression., PMID:39768851
IL-35 May Prevent the Exacerbation of Aspiration Pneumonia Involving Porphyromonas gingivalis by Suppressing IL-17 Production., PMID:39725293
The possible anti-tumor effects of regulatory T cells plasticity / IL-35 in the tumor microenvironment of the major three cancer types., PMID:39693872
Gut microbiota CLA and IL-35 induction in macrophages through Gαq/11-mediated STAT1/4 pathway: an animal-based study., PMID:39636005
T-Cell Phenotypes and Systemic Cytokine Profiles of People Living with HIV Admitted to Hospital with COVID-19., PMID:39597537
Therapeutic potential of Tithonia diversifolia extract: Modulating IL-35, TNF-α, and hematology profile in streptozotocin-induced rat model., PMID:39553780
Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Activation and Cytokine Production., PMID:39543859
The Protective Effect of Esculentoside A on MPL/lpr Mice by Upregulating the Expression of CD19+IL-35+Breg Cells and Interleukin-35., PMID:39500292
Interleukin-35: A key player managing pre-diabetes and chronic inflammatory type 1 autoimmune diabetes., PMID:39493554
Immunological and cytokine profile (IL-25 and IL-35) in patients with Entamoeba histolytica infection in Southern Iraq., PMID:39463702
Regional variations in serum IL-35 levels and association with systemic lupus erythematosus: a systematic review and meta-analysis., PMID:39438756
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients., PMID:39364404
Cytokine Signature Differences in Major Phenotypic Groups of Behçet Disease., PMID:39353077
Changes and significance of Th1/Th2 and Treg/Th17 cells and their cytokines in patients with alopecia areata., PMID:39293523
The Impact of Thyroiditis on the Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes., PMID:39273664
Ebi3 Binding to IFN-γ and IL-10 Limits Their Function., PMID:39240167
Interleukin-6, -17, and -35 levels in association with clinical status in stage III and stage IV periodontitis: a cross-sectional study., PMID:39215253
Relation of T Cell Profile with Vitamin D Receptor and Vitamin D-Binding Protein Gene Polymorphisms in Atopy., PMID:39201708
Immunoregulatory Cells and Cytokines Discriminate Disease Activity Score 28-Remission Statuses and Ultrasound Grades in Rheumatoid Arthritis Patients with Non-High Disease Activity., PMID:39201379
[Clinical Significance of the Levels of Peripheral Blood Tregs and Cytokines IL-35, TGF-β and IL-10 in Hemophilia A Patients with FⅧ Inhibitor]., PMID:39192419
IL-35 promotes IL-35+IL-10+ Bregs and Conventional LAG3+ Tregs in the lung tissue of OVA-Induced Asthmatic Mice., PMID:39127869
The potential therapeutic role of IL-35 in pathophysiological processes in type 1 diabetes mellitus., PMID:39126765
The IL-12 family of cytokines: pathogenetic role in diabetic retinopathy and therapeutic approaches to correction., PMID:39120722
For research use only. Not for human or drug use.
