Catalog No.
EHJ92101
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Lys140
Predicted molecular weight
42.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6W8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis., PMID:40107673
Peripheral ICOS+CD4 T cell frequency: An indicator for short-term progression in resectable advanced gastric cancer following platinum-based chemotherapy., PMID:40025773
Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model., PMID:39905410
Early changes of peripheral circulating immune subsets induced by PD-1 inhibitors in patients with advanced malignant melanoma and non-small cell lung cancer., PMID:39736542
Activin A promoted the anti-tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma., PMID:39727149
Role of Balanced Involvement of the ICOS/ICOSL/Osteopontin Network in Cutaneous Wound Healing., PMID:39596455
Expression of STAT- and T-cell-related genes in women with first-line treatment of relapsing-remitting multiple sclerosis., PMID:39545481
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis., PMID:39532433
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases., PMID:39465485
Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment., PMID:39378431
In vitro modulation of T cells in myasthenia gravis by low-dose IL-2., PMID:39285833
Discovery of ICOS-Targeted Small Molecules Using Affinity Selection Mass Spectrometry Screening., PMID:39269728
Uncovering the Expression Pattern of the Costimulatory Receptors ICOS, 4-1BB, and OX-40 in Exhausted Peripheral and Tumor-Infiltrating Natural Killer Cells from Patients with Cervical Cancer., PMID:39201462
Early Onset Inflammatory Bowel Disease Due to Immunodeficiency as a Result of ICOS Gene Homozygous Mutation., PMID:39129221
ICOS-ICOSL pathway enhances NKT-like cell antiviral function in pregnant women with COVID-19., PMID:39113896
Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus., PMID:38987586
Circular RNA CircZNF644 Facilitates Circulating Follicular Helper T Cells Response in Patients with Graves' Disease., PMID:38966668
Prognostic and therapeutic potential of imbalance between PD-1+CD8 and ICOS+Treg cells in advanced HBV-HCC., PMID:38877825
Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy., PMID:38861924
Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS)., PMID:38845009
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells., PMID:38811842
Genetically Engineered CLDN18.2 CAR-T Cells Expressing Synthetic PD1/CD28 Fusion Receptors Produced Using a Lentiviral Vector., PMID:38700775
ICOS agonist vopratelimab modulates follicular helper T cells and improves B cell function in common variable immunodeficiency., PMID:38621471
The Expression and Prognostic Significance of ICOS in NSCLC Integrated Pan-Cancer and Multi-Omics Analyses., PMID:38616999
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia., PMID:38615511
Immune effector dysfunction signatures predict outcomes in patients with colorectal cancer., PMID:38552290
ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype., PMID:38517331
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development., PMID:38459032
Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy., PMID:38454393
Synovial inducible costimulator is correlated with severity in knee osteoarthritis., PMID:38441341
Sex-specific differences in ICOS+ T helper cell differentiation in systemic lupus erythematosus patients with low disease activity., PMID:38427068
The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5-ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma., PMID:38424520
The added value of the HFA/ICOS score in the prediction of chemotherapy-related cardiac dysfunction in breast cancer., PMID:38305134
Identification of CD38, CD97, and CD278 on the HIV surface using a novel flow virometry screening assay., PMID:38155248
Molecular and clinical characterization of ICOS expression in breast cancer through large-scale transcriptome data., PMID:38127899
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells., PMID:38033053
Discovery of ICOS-Targeted Small Molecules Using Pharmacophore-Based Screening., PMID:37845178
Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation., PMID:37633240
CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren's Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells., PMID:37569326
ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study., PMID:37338463
Thymoma patients with or without myasthenia gravis have increased Th17 cells, IL-17 production and ICOS expression., PMID:37329662
Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils., PMID:37325657
Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation., PMID:37270182
Granulocyte-Macrophage Colony-Stimulating Factor Influence on Soluble and Membrane-Bound ICOS in Combination with Immune Checkpoint Blockade., PMID:37262321
Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56dimCD16bright natural killer cells during kidney allograft antibody-mediated rejection showing a new link between adaptive and innate humoral allo-immunity., PMID:37220805
Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression., PMID:37086778
Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells., PMID:37081789
Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101)., PMID:36862144
Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapy., PMID:36855091
Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma., PMID:36826995
For research use only. Not for human or drug use.
